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Pharmaceutical composition of 12 complex vitamins for injection and preparation method thereof

A technology of complex vitamins and compositions, which is applied in the direction of drug combinations, pharmaceutical formulas, active ingredients of hydroxyl compounds, etc., and can solve problems such as fetal suffocation and fetal asphyxia.

Inactive Publication Date: 2013-04-03
SHANXI PUDE PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Glycocholic acid and soybean phospholipids are indeed good solubilizers, and have a good solubilizing effect on 12 kinds of multivitamins for injection. However, glycocholic acid is a physiologically active substance, and it also has its shortcomings. The 12 kinds of multivitamins for injection of glycocholic acid are not suitable for people with high glycocholic acid, especially pregnant women. High glycocholic acid is cholestasis, which is a complication of many pregnant women in the middle and late stages of pregnancy. , Pregnant women are high in glycocholic acid, which has no effect on the pregnant woman itself, but has a great impact on the fetus. It is likely to cause fetal asphyxia, and it may also cause fetal asphyxia during childbirth. It should be taken seriously

Method used

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  • Pharmaceutical composition of 12 complex vitamins for injection and preparation method thereof
  • Pharmaceutical composition of 12 complex vitamins for injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Embodiment 1: Preparation of 12 kinds of multivitamin compositions for injection

[0054] The prescription is:

[0055] Raw materials

Dosage

Vitamin A Palmitate

3500,000 units

Cholecalciferol

2200,000 units

Racemic α-Tocopherol

10.2g

ascorbic acid

125g

Nicotinamide

46g

Dexpanthenol

16.15g

Pyridoxine Hydrochloride

5.5g

riboflavin sodium phosphate

5.67g

Thiamine pyrophosphate tetrahydrate

5.8g

folic acid

414mg

D-Biotin

69mg

Cyanocobalamin

6mg

Polysorbate 80

200g

Mannitol

550g

[0056] Add water for injection to 5000ml, and make 1000 sticks in total.

[0057] Preparation:

[0058] (1) Solution preparation and filling: in the aseptic operation room, avoid light operation

[0059] A, take cyanocobalamin 6mg by prescription and be dissolved in its 18ml water for injection, standby;

[0060] B. Weigh ...

Embodiment 2

[0068] Embodiment 2: Preparation of 12 kinds of multivitamin compositions for injection

[0069] The prescription is:

[0070] Raw materials

Dosage

Vitamin A Palmitate

4000,000 units

Cholecalciferol

3000,000 units

Racemic α-Tocopherol

5g

ascorbic acid

200g

Nicotinamide

60g

Dexpanthenol

15g

Pyridoxine Hydrochloride

5g

riboflavin sodium phosphate

10g

Thiamine pyrophosphate tetrahydrate

10g

folic acid

600mg

D-Biotin

100mg

Cyanocobalamin

6mg

Polysorbate 80

300g

Mannitol

600g

sodium hydroxide

Adjust pH to 5.9

[0071] Add water for injection to 5000ml, and make 1000 sticks in total.

[0072] Preparation:

[0073] (1) Solution preparation and filling: in the aseptic operation room, avoid light operation

[0074] A, take cyanocobalamin 6mg by prescription and be dissolved in its 18ml water for inje...

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PUM

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Abstract

The invention provides a pharmaceutical composition of 12 complex vitamins for injection and a preparation method thereof. The pharmaceutical composition of 12 complex vitamins for injection provided by the invention comprises the active ingredients of vitamin A palmitate, cholecalciferol, racemic alpha-tocopherol, ascorbic acid, nicotinamide, dexpanthenol, pyridoxine hydrochloride, riboflavin sodium phosphate, tetrahydrate thiamine pyrophosphate, folic acid, D-biotin and cyanocobalamin, and auxiliary materials namely polysorbate 80 and mannitol. The prescription provided by the invention does not contain auxiliary material glycocholic acid, and can be clinically used for people with over-high glycocholic acid.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to 12 compound vitamin pharmaceutical compositions for injection and a preparation method thereof Background technique [0002] 12 multivitamins for injection, the active ingredients are vitamin A palmitate, cholecalciferol, racemic α-tocopherol, ascorbic acid, niacinamide, dexpanthenol, pyridoxine hydrochloride, riboflavin sodium phosphate, tetrahydrate Thiamine pyrophosphate, folic acid, D-biotin, cyanocobalamin. This product is an intravenous vitamin supplement. [0003] This product is suitable for children over 11 years old and adults receiving parenteral nutrition multivitamin daily dosage and routine intravenous requirement in other situations, including surgery, extensive burns, fractures and other traumas, severe infectious diseases and coma. It can be used for the emergency response of the body's metabolism and the lack of tissue nutrition under continuous sev...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/714A61K31/593A61K31/07A61K31/355A61K31/375A61K31/455A61K31/164A61K31/4415A61K31/675A61K31/519A61K31/4188A61P3/02
Inventor 李立忠王勇解晓荣李润宝苏志强姚荷云闫洁胡成伟
Owner SHANXI PUDE PHARMA CO LTD
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