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Method and dedicated chip for preparation of micron calcium alginate filament based on microfluidic chip

A technology of microfluidic chips and calcium alginate, applied in chemical instruments and methods, laboratory containers, laboratory utensils, etc.

Active Publication Date: 2013-03-20
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] But so far, it is still a very challenging task to use sodium alginate solution to prepare calcium alginate gels with more diverse shapes and compositions, and more powerful functions.

Method used

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  • Method and dedicated chip for preparation of micron calcium alginate filament based on microfluidic chip
  • Method and dedicated chip for preparation of micron calcium alginate filament based on microfluidic chip
  • Method and dedicated chip for preparation of micron calcium alginate filament based on microfluidic chip

Examples

Experimental program
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Effect test

Embodiment 1

[0027] Mineral oil droplets of two different colors are arranged alternately within calcium alginate microfilaments.

[0028] Stained by adding Sudan orange and Sudan black respectively to mineral oil. Two mineral oils of different colors were passed into inlet 1 and inlet 2 of the chip droplet dispersion phase respectively. Program the air pump valve controller, the two air pump valve control units squeeze the dispersed phase channel once every 400ms, and the extrusion time interval between the two units is 200ms, and set the flow rate of the three continuous phases of sodium alginate solution to 1ul / min , the flow rate of the continuous phase of the sodium alginate solution in the cross-shaped droplet spacing adjustment unit is 1ul / min. The concentration of sodium alginate solution used is 2% (w / w). The chip is placed flat, and the outlet is immersed in a calcium chloride solution with a concentration of 4% (w / w). The width and height of the outlet are both 200um. Calcium ...

Embodiment 2

[0030] Droplets of two different compositions are arranged alternately within calcium alginate microfilaments.

[0031] Pass NOA63 photoresist liquid and FC-40 fluorocarbon oil into inlet 1 and inlet 2 of the chip droplet dispersion phase respectively. Program the air pump valve controller, the two air pump valve control units squeeze the dispersed phase channel once every 400ms, and the extrusion time interval between the two units is 200ms, and set the flow rate of the three continuous phases of sodium alginate solution to 1ul / min , the flow rate of the continuous phase of the sodium alginate solution in the cross-shaped droplet spacing adjustment unit is 1ul / min. The concentration of sodium alginate solution used is 2% (w / w). The chip is placed flat, and the outlet is immersed in a calcium chloride solution with a concentration of 4% (w / w). The width and height of the outlet are both 200um. Calcium alginate microfilaments containing interphase droplets of NOA63 and FC-40 c...

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Abstract

The present invention provides a method and a dedicated chip for preparation of micron calcium alginate filaments based on a microfluidic chip. By using the chip and the method, calcium alginate microfilament with a minimum diameter of 20 [mu]m can be prepared, calcium alginate microfilaments interiorly including a dispersed phase of spherical structure of other materials can be prepared, and calcium alginate microfilaments with special morphology can be prepared. By using an independent fluid path and a gas path control system of the microfluidic chip, combined with a micro-injection pump and a gas pump valve system, the diameter of the calcium alginate microfilaments can be controlled; the material dispersed phase with the special structure in the microfilaments, including pitch, size, composition and sequence, can be highly-controlled arranged; and the special structure of the filaments can be adjusted. The method and the platform provided by the present invention can highly-controlled prepare calcium alginate filaments, the preparation process is stable, and morphology of the product is homogeneous, and the method is simple.

Description

Technical field: [0001] The invention belongs to the intersecting field of new material technology and microfluidic technology, and specifically relates to a method for preparing micron-scale calcium alginate filaments based on a microfluidic chip and a special chip. Background technique: [0002] The invention relies on microfluidic technology. Microfluidic chip (microfluidic chip), also known as lab on a chip, refers to the integration of the basic operating units of conventional laboratories on a chip of several square centimeters (or even smaller), forming a network of microchannels. , a technology that uses controllable fluid throughout the entire system to replace various functions of conventional laboratories. [0003] Sodium alginate is a natural polysaccharide carbohydrate extracted from brown algae. The molecular chain of sodium alginate contains a large number of hydroxyl and carboxyl groups. Using calcium chloride solution as a cross-linking agent can form a cr...

Claims

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Application Information

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IPC IPC(8): B01L3/00B01J19/00C08B37/04
CPCY02P20/141
Inventor 秦建华于跃姜雷
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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