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Ophthalmic gel medicinal composition and preparation method thereof

A technology of ophthalmic gel and composition, which is applied in the field of ophthalmic gel pharmaceutical composition and its preparation, can solve problems such as visual impairment, and achieve the effects of convenient storage, stable and controllable quality, and reasonable uniform dispersion

Inactive Publication Date: 2013-03-13
XIAN TAKOMED PHARMA TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although conjunctivitis itself is generally not a serious visual impact, it can lead to visual impairment when the inflammation spreads to the cornea or causes complications

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A pharmaceutical composition for ophthalmic gel is prepared by the following steps:

[0024] a) Formulation:

[0025] Tobramycin 0.15g

[0026] Dexamethasone 0.05g

[0027] Glycerin 6000g

[0028] Sodium Carboxymethyl Cellulose 2800g

[0029] Distilled water to make up to 10000ml

[0030] Made into 1000 sticks, each 10g.

[0031] b) Take the weight of glycerin and sodium carboxymethyl cellulose, add appropriate amount of distilled water, let it dissolve or fully swell, and set aside;

[0032] c) Add the tobramycin and dexamethasone of the above weight into step b), stir, dissolve, and mix well; then add distilled water to a sufficient amount (up to 10000ml);

[0033] d) Stir, pack, and that's it.

Embodiment 2

[0035] A pharmaceutical composition for ophthalmic gel is prepared by following steps:

[0036] a) Formulation:

[0037] Tobramycin 0.15g

[0038] Dexamethasone 0.05g

[0039] Glycerin 7000g

[0040] Carbomer 800g

[0041] Distilled water to make up to 10000ml

[0042] Made into 1000 sticks, each 10g.

[0043] b) Take the weight of glycerin and sodium carboxymethyl cellulose, add appropriate amount of distilled water, let it dissolve or fully swell, and set aside;

[0044] c) Add the tobramycin and dexamethasone of the above weight into step b), stir, dissolve, and mix well; then add distilled water to a sufficient amount (up to 10000ml);

[0045] d) Stir, pack, and that's it.

Embodiment 3

[0047] A pharmaceutical composition for ophthalmic gel is prepared by following steps:

[0048] a) Formulation:

[0049] Tobramycin 0.15g

[0050] Dexamethasone 0.05g

[0051] Glycerin 7500g

[0052] Beeswax 200g

[0053] Distilled water to make up to 10000ml

[0054] Made into 1000 sticks, each 10g.

[0055]b) Take the weight of glycerin and sodium carboxymethyl cellulose, add appropriate amount of distilled water, let it dissolve or fully swell, and set aside;

[0056] c) Add the tobramycin and dexamethasone of the above weight into step b), stir, dissolve, and mix well; then add distilled water to a sufficient amount (up to 10000ml);

[0057] d) Stir, pack, and that's it.

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PUM

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Abstract

The invention discloses an ophthalmic gel medicinal composition and a preparation method thereof. The medicinal composition containing tobramycin and dexamethasone, disclosed by the invention, has the effect of treating anterior uveitis and keratitis; the ophthalmic gel medicinal composition is prepared through a scientific and reasonable production process; and the product is definite in function, controllable in quality and safe to take. The preparation method of the medicinal composition is simple, and the preparation process can be finished by conventional equipment.

Description

technical field [0001] The invention belongs to the field of medicines, in particular to an ophthalmic gel pharmaceutical composition and a preparation method thereof. Background technique [0002] Conjunctivitis is a general term for the inflammatory reaction of conjunctival tissue under the action of external factors and the body's own factors. Although conjunctivitis itself is generally not serious for vision, it can lead to vision impairment when the inflammation spreads to the cornea or causes complications. [0003] Keratitis can be divided into two types: ulcerative keratitis, also known as corneal ulcer, and non-ulcerative keratitis, that is, deep keratitis. Caused by internal and external factors. Inflammation caused by corneal trauma, bacteria and viruses invading the cornea. A foreign body sensation, stinging or even burning sensation in the affected eye. Mixed hyperemia of the bulbar conjunctival surface with symptoms of photophobia, lacrimation, visual distu...

Claims

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Application Information

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IPC IPC(8): A61K31/702A61K31/573A61K9/06A61P27/02A61P31/04
Inventor 唐永红钱博
Owner XIAN TAKOMED PHARMA TECH
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