Iodine-chitosan solution formula and preparation method thereof

Abstract

The invention discloses an iodine-chitosan solution formula and a preparation method thereof. The raw materials of the iodine-chitosan solution include iodine-chitosan, glacial acetic acid, polysorbate-20, glycerol, potassium iodate and purified water. The preparation method comprises the following steps that: (1) the materials are weighed; (2) the glacial acetic acid, polysorbate-20, glycerol and purified water are added into the iodine-chitosan and uniformly mixed to totally dissolve; (3) the potassium iodate is dissolved by the purified water and then added into the materials and uniformly mixed; (4) the purified water is added inside the materials to reach 100 percent and the materials are uniformly mixed; and (5) the mixture is filtered, filled, packaged to obtain the iodine-chitosan solution. In the iodine-chitosan solution, the iodine-chitosan plays the role of disinfection and sterilization, the glacial acetic acid plays the role of pH value adjustment and synergetic solubilization, the polysorbate-20 plays the role of solubilization, the glycerol plays the role of blending and moisture retention, the potassium iodate plays the role of a stabilizer, and the iodine-chitosan plays the role of disinfection; and the iodine-chitosan solution can be used for skin disinfection of operation sites or injection sites and auxiliary treatment of small cuts, and also can be used for washing treatment of vagina inflammation and treatment and disinfection of oral diseases.

Description

technical field [0001] The invention relates to a medical dressing, in particular to a dressing containing polysaccharide derivatives, in particular to chitosan iodine solution. Background technique [0002] Iodine has been used for body disinfection for 150 years, but due to the low solubility of iodine in water, it is only 1.315×10 at 25°C. -3 mol / L, it cannot be used as an aqueous preparation; it is easy to sublimate at room temperature, and the content is unstable; it is irritating to the skin and mucous membranes, which limits its wide application. At present, most of the widely used iodine disinfectants are based on organic polymers or surface active substances, and through the network structure or micelles formed between the carrier molecules, iodine is "bound" in it by the conformational effect of electrons and space. , thereby changing the free state of iodine in general iodine preparations, enhancing its stability and bactericidal effect, and reducing irritation a...

AI Technical Summary

Problems solved by technology

[0003] Chitosan (chitosan) is the only positively charged branched polysaccharide in nature. It has antibacterial, antitumor, immune enhancement and other functions. It has good biocompatibility and is non-irritating and non-toxic. Due to 2- NH 2 Chitosan has a certain antibacterial function, but the antibacterial performance is limited, and it is affected by conditions such as chitosan molecular weight and deacetylation degree.