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Molecularly imprinted polymeric microsphere resin applicable to aqueous solution system and preparing method thereof

A molecular imprinting, polymer technology, applied in the direction of alkali metal compounds, chemical instruments and methods, other chemical processes, etc., can solve problems such as limiting wider applications

Active Publication Date: 2013-03-06
NANKAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this method requires a large number of high-throughput condition optimization experiments, which greatly limits its wider application.

Method used

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  • Molecularly imprinted polymeric microsphere resin applicable to aqueous solution system and preparing method thereof
  • Molecularly imprinted polymeric microsphere resin applicable to aqueous solution system and preparing method thereof
  • Molecularly imprinted polymeric microsphere resin applicable to aqueous solution system and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0029]Add 0.83mmol of 2,4-D into a 100mL round-bottomed flask filled with 60mL of methanol / water (4:1, v / v), stir it with a magnet to dissolve it completely, and then add 0.83mmol of 4-vinylpyridine. After fully contacting for half an hour, add 2.50mmol EDMA, 0.055mmol small molecular chain transfer agent cumyl dithiobenzoate (CDB), 0.033mmol poly N-isopropylacrylamide macromolecular chain transfer agent and 0.028mmol Azobisisobutyronitrile (AIBN). After deoxygenating with argon for 30 min, the reaction system was sealed, placed in a constant temperature oil bath at 60°C, reacted for 6 h, and the reaction product was obtained by suction filtration.

[0030] The reaction product was washed successively with methanol / acetic acid (9:1, v / v) and methanol until the template-free molecules were washed out. After air-drying, vacuum-dry at 40° C. for 48 hours to obtain molecularly imprinted polymer microspheres with hydrophilic poly-N-isopropylacrylamide polymer brushes on the surfac...

example 2

[0033] Add 0.83mmol of 2,4-D into a 100mL round-bottomed flask filled with 60mL of methanol / water (4:1, v / v), stir it with a magnet to dissolve it completely, and then add 0.83mmol of 4-vinylpyridine. After fully contacting for half an hour, add 2.50mmol EDMA, 0.055mmol small molecule chain transfer agent cumyl dithiobenzoate (CDB), 0.110mmol polyethylene glycol macromolecular chain transfer agent and 0.028mmol azodiiso Nitrile (AIBN). After deoxygenating with argon for 30 min, the reaction system was sealed, placed in a constant temperature oil bath at 60°C, reacted for 10 h, and the reaction product was obtained by suction filtration.

[0034] The reaction product was washed successively with methanol / acetic acid (9:1, v / v) and methanol until no template molecules were washed out. After air-drying, vacuum-dry at 40° C. for 48 hours to obtain molecularly imprinted polymer microspheres with hydrophilic polyethylene glycol polymer brushes on the surface.

[0035] In the prepa...

example 3

[0037] Add 0.25mmol of theophylline into a 250mL round-bottomed flask filled with 100mL of methanol / water (4:1, v / v), stir with a magnet to dissolve it completely, then add 1mmol of methacrylic acid, mix thoroughly for half an hour, and then 4mmol EDMA, 0.09mmol small molecular chain transfer agent CDB, 0.09mmol poly-N-isopropylacrylamide macromolecular chain transfer agent and 0.04mmol AIBN were added successively. After stirring for half an hour, deoxygenate with argon gas for 30 minutes, seal the reaction system, place it in a constant temperature oil bath at 60°C, react for 6 hours, and obtain the reaction product by suction filtration.

[0038] The reaction product was washed successively with methanol / acetic acid (9:1, v / v) and methanol until no template molecule was washed out. After air-drying, vacuum-dry at 40° C. for 48 hours to obtain molecularly imprinted polymer microspheres with hydrophilic poly-N-isopropylacrylamide polymer brushes on the surface.

[0039] In t...

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Abstract

The invention relates to a simple preparing method of molecularly imprinted polymeric microspheres applicable to an aqueous solution system. Crosslinking degree of the molecularly imprinted polymeric microspheres is larger than 50%, grain size of each molecularly imprinted polymeric microsphere ranges from 0.2-5 micrometers, and hydrophilic macromolecule brushes are grated on the surfaces of the molecularly imprinted polymeric microspheres. The molecularly imprinted polymeric microspheres are synthesized in one step via a reversible addition-fragmentation chain transfer (RAFT) precipitation polymerization technology induced by hydrophilic macromolecular chain transfer agent. The preparing method is simple in synthesis, wide in application range, pure in product and the like. The molecularly imprinted polymeric microspheres prepared by the method have wide application prospect in multiple fields including chromatographic support, biological sample analysis, medical clinical immunoassay, food and environmental monitoring, mimic enzyme catalysis, biomimetic sensor and the like.

Description

Technical field [0001] The present invention relates to a simple preparation method of molecularly imprinted polymer microspheres with excellent molecular recognition function in pure aqueous solution, in particular to a one-step process of molecularly imprinted polymer microspheres with hydrophilic polymer brushes on the surface method of preparation. Background technique [0002] Molecular imprinting technology is a simple and feasible new method to prepare synthetic receptors with specific molecular recognition sites developed on the basis of polymer chemistry, biochemistry, materials chemistry and bionic technology in recent years. The molecularly imprinted polymers (Molecularly Imprinted Polymers, referred to as MIPs) prepared by it have the advantages of excellent affinity and specific selectivity for guest molecules, good stability and easy synthesis, so they have become the research center in the field of molecular recognition in the world. hotspot. At present, the...

Claims

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Application Information

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IPC IPC(8): C08F226/06C08F220/06C08F222/14C08F2/38C08J9/26B01J20/26B01J20/28B01J20/30
Inventor 张会旗潘国庆张莹马悦
Owner NANKAI UNIV
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