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Method for preparing hydrogel film for curing chemotherapeutic phlebitis

A technology of gel film and sugar water, which is applied in the field of hydrogel film preparation, can solve the problem of inability to alleviate the degree of chemotherapy drug toxicity and damage to veins and surrounding tissues, and achieve the prevention and treatment of chemotherapy drug extravasation damage, phlebitis, high Effects of environmental friendliness and good biodegradability

Inactive Publication Date: 2013-02-06
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It has been reported in foreign literature that heparin gel has an obvious local analgesic effect on chemotherapy-induced phlebitis, but it cannot reduce the toxicity and damage of chemotherapy drugs to veins and surrounding tissues

Method used

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  • Method for preparing hydrogel film for curing chemotherapeutic phlebitis
  • Method for preparing hydrogel film for curing chemotherapeutic phlebitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Embodiment one: the preparation of water-soluble hydroxypropyl chitosan

[0011] 40g of chitosan was added into 250ml of isopropanol and stirred for 30 minutes. Then 30 ml of sodium hydroxide solution (33%, w / v) was added to the mixture. The mixed solution was stirred for 1 h and added to the flask at room temperature, sealed, and frozen overnight at -20 °C. 40 ml of 10% (v / v) catalyst solution (tetramethylammonium hydroxide) was added dropwise to the mixture, followed by 400 ml of propylene oxide. The reaction was stirred at room temperature for 1 h, and the reaction temperature was slowly raised to 60° C., and the reaction time was 7 h. Add the reaction solution to 4 times the volume of ethanol solution to obtain a precipitate, wash the precipitate twice with 10 times the volume of ethanol, redissolve the precipitate with deionized water, dialyze and freeze-dry to obtain high-purity hydroxypropyl chitosan .

Embodiment 2

[0012] Embodiment 2: Preparation of photocrosslinkable chitosan

[0013] Get 10g of prepared hydroxypropyl chitosan and dissolve it in 50ml of 50mM TEMED solution and stir until the hydroxypropyl chitosan is completely dissolved, then add 5g of EDC and 10g of 4-azidobenzoic acid. The reaction was stirred for 50 h at room temperature at 25°C. Dialyzed in deionized water for two days and freeze-dried to obtain photocrosslinkable chitosan.

Embodiment 3

[0014] Example Three: Preparation of Photocrosslinked Chitosan Hydrogel Film

[0015] 400 μl of photo-crosslinkable chitosan aqueous solution with a concentration of 40 mg / ml was spread in a petri dish with a diameter of 7 cm. A petri dish coated with photo-crosslinkable chitosan was irradiated with ultraviolet light with a wavelength of 365 nm and a power of 20 W for 500 s to obtain a photo-crosslinkable chitosan hydrogel film with a film thickness of about 0.1 mm.

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Abstract

The invention belongs to the technical field of biomedical materials and specifically relates to a method for preparing a hydrogel film for curing chemotherapeutic phlebitis. The method includes introducing an azide group (4-azidobenzoic acid) with optical reaction activity onto an amino group of water-soluble hydroxypropyl chitosan to prepare light cross-linked azide hydroxypropyl chitosan, and subjecting an azide hydroxypropyl chitosan aqueous solution to irradiation and crosslinking by an ultraviolet lamp to obtain the chitosan hydrogel film with bioadhesion. According to the chitosan hydrogel film, general characteristics of blood stopping, pain relieving, bacterium inhibiting, anti-inflammation and antioxidation of chitosan are achieved, advantages of good biocompatibility, good moisture retention, good water vapor permeability and high adhesion strength of hydrogel materials are achieved, and the chitosan hydrogel film is convenient to use, good in comfort degrees and good in effect of preventing and curing the chemotherapeutic phlebitis.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a preparation method of a hydrogel film for preventing and treating chemotherapeutic phlebitis. Background technique [0002] Chemotherapy of antineoplastic drugs (referred to as chemotherapy) is one of the three major means of comprehensive treatment of malignant tumors, and intravenous infusion of chemotherapy drugs is an important route of administration. And the strong local stimulation of high-concentration drugs can lead to chemotherapy-induced phlebitis, causing redness, swelling, heat pain in the vein of administration and adjacent tissues, blackening, hardening and cord-like changes in the veins, and even local skin blisters, ulcers, and subcutaneous tissue necrosis. Limb dysfunction, etc. According to statistics, 50% to 80% of chemotherapy patients may have different degrees of venous inflammation, which brings pain to patients and also brings ...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08J3/28C08J3/24C08L5/08C08B37/08A61L15/28
Inventor 滕丽萍顾晨晨刘丽娜陈潇潇陈凤波王玉骞陈敬华
Owner JIANGNAN UNIV
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