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Astragalus mongholicus injection and preparation method thereof

A technology of Astragalus injection and injection, which is applied in the direction of medical formula, medical preparations containing active ingredients, drug delivery, etc., can solve the problem of not having the effect of the two major types of ingredients to exert curative effects together, and can not simultaneously improve the total saponins of Astragalus and Astragalus total flavonoids content and other issues, to achieve good adjuvant therapeutic effect, excellent effect, easy to operate

Active Publication Date: 2013-01-30
HEILONGJIANG ZBD PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0016] In addition, there are also some research methods for separately purifying total astragalus saponins or total astragalus flavonoids through extraction methods. The resulting composition is a single category with high purity, and cannot simultaneously increase the content of total astragalus saponins and total astragalus flavonoids in the traditional astragalus preparation process , and the obtained composition or preparation no longer has the effect of the two major types of ingredients working together to exert curative effect

Method used

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  • Astragalus mongholicus injection and preparation method thereof
  • Astragalus mongholicus injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Embodiment 1: Astragalus Injection

[0054] 1. Take 1000g of Astragalus membranaceus, add water to decoct twice, add water 10 times and 8 times the weight of Astragalus membranaceus respectively, decoct for 2 hours each time, combine the decoction liquid, filter, and concentrate the filtrate to 745ml (each 1ml is equivalent to Original medicinal material 1.34g), add 95% ethanol to make the ethanol content 73%, refrigerated for 20 hours, filter, recover ethanol and concentrate until no alcohol smell, add water for injection to dilute to 385ml (each 1ml is equivalent to 2.60g of original medicinal material ), refrigerated for 20 hours, filtered to obtain a water extract, and recovered medicinal residues;

[0055] 2. The recovered dregs were refluxed and extracted twice with ethanol, each time adding 60% ethanol in an amount 8 times the volume of Astragalus membranaceus, the extraction time was 1.5 hours each time, the extracts were combined, the ethanol was recovered and ...

Embodiment 2

[0057] Embodiment 2: Astragalus Injection

[0058] 1. Take 1000g of Astragalus membranaceus, add water to decoct twice, add 8 times the weight of Astragalus membranaceus for 2 hours, add 6 times the amount of water for 1.5 hours, combine the decoction liquid, filter, Concentrate the filtrate to 675ml (each 1ml is equivalent to 1.48g of the original medicinal material), add 95% ethanol to make the ethanol content to 70%, put it in refrigeration for 18 hours, filter, recover the ethanol and concentrate until it has no alcohol smell, add water for injection to dilute to 392ml (Each 1ml is equivalent to 2.55g of the original medicinal material), refrigerated for 18 hours, filtered to obtain a water extract, and recovered medicinal residues;

[0059] 2. The reclaimed dregs were extracted twice with ethanol backflow, adding 50% ethanol with 8 times and 6 times the volume of Radix Astragali each time, and the extraction time was 2 hours and 1.5 hours respectively. The extracts were c...

Embodiment 3

[0061] Embodiment 3: Astragalus Injection

[0062] 1. Take 1000g of astragalus, add water and decoct 3 times, add 10 times, 8 times, and 8 times of the weight of astragalus respectively, decoct for 1.5 hours each time, combine the decoction liquid, filter, and concentrate the filtrate to 688ml ( Each 1ml is equivalent to 1.45g of the original medicinal material), add 95% ethanol to make the ethanol content to 72%, refrigerate for 12 hours, filter, recover the ethanol and concentrate until it has no alcohol smell, add water for injection to dilute to 396ml (each 1ml is equivalent to 2.53g of the original medicinal material), refrigerated for 12 hours, filtered to obtain a water extract, and recovered medicinal residues;

[0063] 2. The recovered dregs were extracted twice with ethanol under reflux, adding 10 times and 8 times the volume of Astragalus 95% ethanol each time, the extraction time was 1.5 hours, the extracts were combined, the ethanol was recovered and concentrated ...

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Abstract

The invention relates to Astragalus mongholicus injection and a preparation method thereof. The injection contains two effective components: astragaloside and calycosin-7-glycoside. 1ml of Astragalus mongholicus injection contains 0.08-0.8mg of astragaloside and 0.02-0.4mg of calycosin-7-glycoside, wherein the astragaloside accounts for 1-10 percent of total solids, and the calycosin-7-glycoside accounts for 0.20-5 percent of the total solids. The injection provided by the invention is better in adjuvant therapeutic effect in the aspects of treating myocarditis, myocardial ischemia, cardiac failure, myocardial infarction and arrhythmia, and the therapeutic effect of the injection is superior to that of the prior art.

Description

technical field [0001] The invention relates to the field of astragalus preparations, in particular to an astragalus injection and a preparation method thereof. Background technique [0002] Astragalus is the root of the leguminous herb Astragalus mongolica and Astragalus membranaceus. Pharmacological studies have confirmed that Astragalus has the effects of strengthening the heart and expanding blood vessels, and Astragalus can improve cardiac systolic function while improving cardiac diastolic function, eliminating heart failure. In addition, it has a protective effect on the myocardium, which can protect the myocardium infected with ischemia and hypoxia, ischemia-reperfusion and virus, and can improve the electrical activity of cardiomyocytes, and has anti-arteriosclerosis and other effects. [0003] The chemical components of Astragalus mainly include saponins, flavonoids, polysaccharides and amino acids, among which saponins and flavonoids are the main medicinal compone...

Claims

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Application Information

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IPC IPC(8): A61K36/481A61K31/7048A61K9/08A61P9/04A61P9/06A61P9/10
Inventor 方同华
Owner HEILONGJIANG ZBD PHARMA
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