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Rhizoma bletillae polysaccharide gastric-floating tablet and preparation method and application thereof

The technology of gastric floating tablet and polysaccharide, which is applied in the field of medicine, can solve the problems of complicated preparation process, high cost, restricting the development of gastric floating tablet, etc., and achieves the effects of simple preparation method, high drug loading and easy large-scale production.

Inactive Publication Date: 2013-01-30
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, gastric floating tablets have the most research reports. However, the existing gastric floating tablets are generally prepared by hydrophilic gel, auxiliary floating materials, foaming agents, fillers and release regulators. The drug loading is generally lower than 30%. Complexity and high cost limit the development of gastric floating tablets

Method used

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  • Rhizoma bletillae polysaccharide gastric-floating tablet and preparation method and application thereof
  • Rhizoma bletillae polysaccharide gastric-floating tablet and preparation method and application thereof
  • Rhizoma bletillae polysaccharide gastric-floating tablet and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] prescription:

[0023] White and polysaccharide 100 parts by weight

[0024] Xanthan gum 5 parts by weight

[0025] Glyceryl behenate 5 parts by weight

[0026] Preparation method:

[0027] Mix the prescription amount of Baiji polysaccharide and xanthan gum evenly, granulate with 95% ethanol, dry, granulate, then add the prescription amount of glyceryl behenate and mix for 5 minutes, tablet, finished product inspection, and packaging.

[0028] 【Examination of floating performance in vitro】

[0029] Put the tablet into 0.1mol·L -1 In the HCl solution, the prepared Baiji polysaccharide gastric floating tablet immediately floated on the water surface and lasted for more than 12 hours; through tablet hardness test comparison, the prepared Baiji polysaccharide gastric floating tablet did not float when the pressure exceeded 10kg, and when the pressure was 3-10kg Good floating performance.

[0030] 【Determination of Polysaccharide Content in Bletilla striata】

[0031] ...

Embodiment 2

[0039] prescription:

[0040] White and polysaccharide 100 parts by weight

[0041] Xanthan gum 10 parts by weight

[0042] Glyceryl behenate 10 parts by weight

[0043] Preparation method:

[0044] Mix the prescription amount of Baiji polysaccharide and xanthan gum evenly, granulate with 95% ethanol, dry, granulate, then add the prescription amount of glyceryl behenate and mix for 5 minutes, tablet, finished product inspection, and packaging.

[0045] 【Examination of floating performance in vitro】

[0046] Put the tablet into 0.1mol·L -1 In the HCl solution, the prepared Baiji polysaccharide gastric floating tablet immediately floated on the water surface and lasted for more than 12 hours; through tablet hardness test comparison, the prepared Baiji polysaccharide gastric floating tablet did not float when the pressure exceeded 10kg, and when the pressure was 3-10kg Good floating performance.

[0047] 【Determination of Polysaccharide Content in Bletilla striata】

[0048...

Embodiment 5

[0056] Clinical Observation

[0057] [General information] Selected 70 patients with gastric ulcer and bleeding, all of the above patients were diagnosed by endoscopy, and excluded patients with coagulation dysfunction, patients who recently took non-steroidal anti-inflammatory drugs, and patients who took glucocorticoids. The above patients were randomly divided into two groups, the observation group and the control group. Among them, there were 35 cases in the observation group, including 22 males and 13 females, the youngest was 21 years old, the oldest was 65 years old, and the average age was (35.7±6.2) years; the control group had 35 cases, 23 males and 12 females, the age The youngest was 22 years old, the oldest was 61 years old, and the average age was (33.6±5.2) years old. There was no statistically significant difference between the two groups in terms of gender and age, and they were comparable.

[0058] [Methods] Patients in the control group were given omeprazo...

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Abstract

The invention discloses a preparation method for a rhizoma bletillae polysaccharide gastric-floating tablet and an application of the rhizoma bletillae polysaccharide gastric-floating tablet and belongs to the technical field of new uses of drugs. The invention relates to a new formulation of rhizoma bletillae polysaccharide, and the new formulation of the rhizoma bletillae polysaccharide is used for treating a gastric ulcer. The gastric-floating tablet is prepared through matching the rhizoma bletillae polysaccharide, xanthan gum and glyceryl behenate by the preparation method disclosed by the invention. The rhizoma bletillae polysaccharide gastric-floating tablet has the characteristics that the preparation method is simple, and a treatment effect on a peptic ulcer is good.

Description

technical field [0001] The invention relates to a bletilla polysaccharide gastric floating tablet, a preparation method and application thereof, and belongs to the technical field of medicine. Background technique [0002] Baiji polysaccharide comes from Baiji tuber and is a neutral heteropolysaccharide composed of mannose and glucose. Studies have shown that Baiji polysaccharide has a unique curative effect on peptic ulcer, can significantly improve the quality of ulcer healing, and reduce the toxic and side effects of long-term medication. Due to its strong anti-peptic ulcer activity and small side effects, Baiji polysaccharide has been paid attention to in recent years. The therapeutic effect of Baiji polysaccharide on ulcer depends on its combination with the ulcer surface. However, due to the gastric emptying effect, the residence time of the common preparation of Baiji polysaccharide in the stomach and duodenum is very short, and most of Baiji polysaccharide enters th...

Claims

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Application Information

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IPC IPC(8): A61K9/22A61K31/715A61K47/36A61P1/04
Inventor 王莹陈书军李明皓尹鸿萍张真真奚涛
Owner CHINA PHARM UNIV
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