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New application of echinacoside

A technology of echinacoside and application, applied in the field of echinacoside, can solve the problems of small side effects, unclear target, unstable and easy to degrade, etc.

Inactive Publication Date: 2013-01-09
ZHONGSHAN HOSPITAL FUDAN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, although many small molecular peptides synthesized have neurotrophic effects, they also have problems such as instability and easy degradation and low permeability of the blood-brain barrier; due to poor receptor selectivity and unknown toxicity, the synthesized peptides with Trk receptor Whether the non-peptide small molecular compounds with agonistic effect can be applied in clinical practice is still questionable
[0005] Traditional Chinese medicine is a precious historical heritage of our country. The treatment of traditional Chinese medicine belongs to empirical medicine. After thousands of years of repeated practice, it has been proved that the curative effect is significant and the side effects are small. However, many mechanisms and targets are still unclear

Method used

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  • New application of echinacoside
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  • New application of echinacoside

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0031] Step 1: Echinacoside can selectively reduce nerve cell damage by activating TrkA / B receptors:

[0032] Select four different types of cells, Hela, CHO, PC12 and primary cultured rat cortical neurons, induce cell damage by mitochondrial respiratory chain inhibitor NaN3, and observe the protective effect of echinacoside on this basis, specific steps for:

[0033] 1. Cell culture:

[0034]1) Culture of cell lines: Hela (CCL-2.2), CHO (CCL-61) and PC12 (CRL-1721) cells were all purchased from ATCC. Hela and CHO cells were cultured with DMEM medium containing 10% fetal bovine serum (Gibco Company), while PC12 cells were cultured with DMEM medium containing 10% horse serum and 5% fetal bovine serum, and the cells grew to 80% confluence after passage The liquid was changed every now and then, and the following administration treatments were carried out.

[0035] 2) Primary culture of cortical neurons in rats: Take healthy fetuses of SD rats about 17 days pregnant, take the ...

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Abstract

The invention provides a new application of echinacoside. Natural micromolecule active compound echinacoside has selective peculiar protection effect on injury of nerve cells, the echinacoside can activate TrkA / B receptors, and the nerve protection effect of the echinacoside can be reversed by restraining the receptors from being activated through Trk receptor specificity inhibitors. Vein medication of the echinacoside can generate obvious nerve protection effect, and simultaneously long-time vein medication causes no obvious liver and renal toxicity.

Description

technical field [0001] The present invention relates to the new use of echinacoside, in particular to the use in the preparation of nerve growth factor receptor agonists. Background technique [0002] Neurotrophic factors mainly include nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophic factor-3 (NT-3) and neurotrophic factor-4 / 5 (NT-4 / 5). Neurotrophic factors play an important role in the growth, differentiation and survival of neurons, and they mainly function by binding to and activating Trk receptors and p75NTR receptors. Among them, the p75NTR receptor belongs to the tumor necrosis factor receptor family, and the Trk receptor is a member of the transmembrane tyrosine kinase receptor family, including TrkA, TrkB and TrkC. NGF is mainly combined with TrkA, BDNF and NT-4 / 5 are mainly combined with TrkB, and NT-3 is mainly combined with TrkC. After neurotrophic factors bind to Trk receptors, they activate the receptors, promote the formation...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7032A61P25/00A61P25/16A61P9/10
Inventor 李文伟朱敏吕传真
Owner ZHONGSHAN HOSPITAL FUDAN UNIV
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