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Pharmaceutical purpose of effective parts of immature Bitter orange or trifoliate-orange root-bark

A technology of effective parts and citrus aurantii, which is applied to medical preparations containing active ingredients, pharmaceutical formulas, drug delivery, etc., can solve problems that have not been reported yet, and achieve the effects of strong pharmacological effects, extensive resources, and simple preparation processes

Active Publication Date: 2010-04-28
JIANGZI QINGFENG PHARMACEUTICALS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Pharmacological experiments have shown that citrus aurantium medicine can increase the contraction rhythm of gastrointestinal smooth muscle in experimental animals, but there is no report on the active ingredients of citrus aurantium and citrus aurantium to promote gastrointestinal motility or the active ingredients and their preparations

Method used

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  • Pharmaceutical purpose of effective parts of immature Bitter orange or trifoliate-orange root-bark

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Example 1 : Citrus aurantium fine powder 600g, extract 4 times with 95% ethanol (crude drug: solvent weight ratio is 1: 6; 1: 4; 1: 4; 1: 4), merge extracts, reclaim ethanol to no alcohol smell, add Distill water to 600ml, and extract the aqueous solution with petroleum ether, ethyl acetate, and n-butanol successively for 6 times, 200ml each time. After concentration of n-butanol extraction part, 90g was obtained, put on D101 type macroporous resin column, eluted with water, 25% ethanol, 50% ethanol, 95% ethanol in sequence, and the 50% ethanol eluted part was concentrated and dried to obtain more than 20% Hesperidin and Naringin mixed total glycosides (55g).

Embodiment 2

[0047] Example 2: 600g of Citrus aurantii fine powder, extracted 3 times with 70% ethanol (the weight ratio of crude drug:solvent is 1:8; 1:6; 1:6), combined the extracts, recovered the ethanol until it had no alcohol smell, and added distilled water to 600ml , and the aqueous solution was sequentially extracted 4 times with petroleum ether, ethyl acetate and n-butanol, 300ml each time. The n-butanol extraction part was concentrated and dried to obtain 82g, which was loaded on a D101 macroporous resin column, and eluted with water, 25% ethanol, 50% ethanol, and 95% ethanol in sequence, and the 50% ethanol eluted part was concentrated and dried to obtain 20% The above hesperidin and naringin (47g).

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Abstract

The invention discloses the effective parts of immature butter orange or trifoliate-orange root-bark or their effective parts composition and preparation method and pharmaceutical purpose, which are extracted with ethanol and water, and can be used for antiphlogistic and cough-relieving. The invention also discloses the pharmaceutical composition using these effective parts as the active constituents, which can be made into various forms including granules, tablets, capsules, drop pills, soft extracts, and liquids.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine. Specifically, it relates to the effective part of Fructus Aurantii or Fructus Aurantii or its composition. The present invention also relates to the preparation method of the effective part. The present invention also relates to the use of the effective part in the preparation of drugs for promoting gastric motility, specifically in the treatment of Or it can be used as medicine for preventing gastric motility deficiency diseases such as bloating, anorexia and dyspepsia, and respiratory tract infection diseases such as bronchitis and cough. Background technique [0002] Fructus aurantii immaturus is the dry young fruit of Citrus aurantium L. and its variants or sweet orange Citrus sinensis Osbeck. It has the effects of dispelling qi and eliminating stagnation, resolving phlegm and dissipating mass, regulating qi and widening the middle, promoting stagnation and reducing swelling. [...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/752A61K9/00A61P1/14A61P11/00
Inventor 孙继寅王广基唐春山叶文才孙旭
Owner JIANGZI QINGFENG PHARMACEUTICALS INC
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