Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Micro-capsules of anti-influenza-virus effective part of phyllanthus urinaria, and preparation method and application thereof

A technology of anti-influenza virus and effective parts, which is applied in the directions of anti-viral agents, medical preparations containing active ingredients, microcapsules, etc., and can solve the problems of preparation of anti-influenza virus active components and preparations of P. , to achieve the effect of simple and easy preparation method, overcoming instability and good effect.

Inactive Publication Date: 2014-05-07
SOUTH CHINA UNIV OF TECH
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] There is no report about the preparation and preparation of anti-influenza virus active components of Phyllostachys phylloxera

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Micro-capsules of anti-influenza-virus effective part of phyllanthus urinaria, and preparation method and application thereof
  • Micro-capsules of anti-influenza-virus effective part of phyllanthus urinaria, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] (1) 1 kg of Phyllanthus phylloxera, add 5 kg, 30% ethanol, heat and extract at 80° C. for 3 hours, filter, and then use the above-mentioned solvent to repeatedly extract the filter residue twice, filter, and combine the filtrates to 2 / 3 of the original volume in vacuum at 60° C. Add D101 macroporous resin to adsorb for 24 hours; take out the macroporous resin and elute with 90% ethanol, concentrate the eluate in vacuum at 50°C to 1 / 3 of the original volume, extract once with an equal volume of dichloromethane, combine the extracts, Concentrate in vacuo at 30°C and dry for 3 hours to obtain 55 g of anti-influenza virus effective fraction of Phyllostachys phylloxera.

[0024] (2) Acrylic resin IV100g is mixed with the capsule material solution of 5% mass fraction with dichloromethane, adds capsule material solution mass fraction 0.5% monoglyceride, 0.1% polyethylene glycol, 20% Phyllostachys anti-influenza virus The effective part is ultrasonically emulsified for 0.5 hour...

Embodiment 2

[0026] (1) 1 kg of Phyllanthus phylloxera, add 10 kg of 80% ethanol and extract by heating at 30°C for 1 hour, filter, and then repeat the extraction once with the above solvent, filter, combine the filtrate and concentrate it in vacuum at 30°C to 1 / 3 of the original volume, add DM130 The macroporous resin was adsorbed for 8 hours; the macroporous resin was taken out and eluted with 50% ethanol. When the eluate was concentrated in vacuum at 60°C to 2 / 3 of the original volume, it was extracted 3 times with an equal volume of ethyl acetate, and the extracts were combined at 50°C. Concentrate in vacuo and dry for 3 hours to obtain 102 g of anti-influenza virus effective fraction of Phyllostachys phylloxera.

[0027] (2) ethyl cellulose 100g is mixed with acetone to form a 10% mass fraction of the capsule material solution, add the capsule material solution mass fraction 5% Tween 80, 0.5% talc, and 10% Phyllophyllum anti-influenza virus effective fraction, Ultrasonic emulsificatio...

Embodiment 3

[0029] (1) 1 kg of Phyllostachys phylloxera, add 8 kg of 50% ethanol and extract by heating at 60°C for 2 hours, filter, and then use the above-mentioned solvent to repeatedly extract the filter residue once, filter, combine the filtrate and concentrate it in vacuum at 50°C to 2 / 3 of the original volume, add HPD600 The macroporous resin was adsorbed for 12 hours; the macroporous resin was taken out and eluted with 70% ethanol, and the eluate was concentrated in vacuum at 50°C to 1 / 3 of the original volume, then extracted twice with an equal volume of n-butanol, and the extracts were combined and stored at 60°C Concentrate in vacuo and dry for 5 hours to obtain 83 g of the anti-influenza virus effective fraction of Phyllanthus phylloxera.

[0030] (2) Hydroxypropyl cellulose 100g is mixed with ethanol into the capsule material solution of 8% mass fraction, adds capsule material solution mass fraction 3% Span 60, 1% silica gel, 5% Phyllostachys anti-influenza virus effective frac...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses micro-capsules of an anti-influenza-virus effective part of phyllanthus urinaria, and a preparation method and application thereof. The preparation method comprises the following steps of: heating and extracting phyllanthus urinaria medicinal materials by using 30 to 80 percent ethanol, recovering the ethanol from an extracting solution, adsorbing by using a macroporous resin, eluting by using 50 to 90 percent ethanol, recovering the ethanol, and extracting the effective part by using dichloromethane, ethyl acetate or n-butyl alcohol; mixing capsule materials, emulsifier, an antisticking agent and a solvent to obtain a mixed solution, adding an aqueous solution of the effective part of the phyllanthus urinaria into the mixed solution, performing ultrasonic emulsification, allowing the mixture to pass through a microfiltration membrane, and spray-drying to obtain the micro-capsules. The micro-capsules can kill influenza virus and can be used for anti-influenza-virus medicines or disinfection of epidemic prevention articles for human or animals. The micro-capsules improve the stability of the effective part of the phyllanthus urinaria and improve the action effect of the effective part obviously.

Description

technical field [0001] The invention relates to the field of pharmaceutical manufacturing, in particular to a method for preparing a microcapsule of the anti-influenza virus effective part of Phyllostachys phylloxera and its application as an antiviral drug. Background technique [0002] Phyllanthus urinaria L is a plant of the genus Phyllanthus urinaria in the family Euphorbiaceae. It is cool in nature, slightly bitter and sweet, and has the effects of calming the liver, annealing, improving eyesight, detoxifying and reducing swelling. Infantile malnutrition, dysentery, snake bites, etc. Since Thyagarajan, an Indian scholar, reported that Phyllanthus phylloxera can make 59% of hepatitis B surface antigen negative, its anti-hepatitis B virus effect has caused extensive research at home and abroad. At present, the main researches on Phyllanthus phylloxera are its anti-tumor effect and anti-hepatitis B virus effect. [0003] Recently, it has been found that Phyllostachys phy...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/47A61K9/50A61P31/16
Inventor 叶勇郭亚
Owner SOUTH CHINA UNIV OF TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com