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Moistureproof film coating agent for traditional Chinese medicine tablets and preparation method thereof

A film coating agent and tablet technology, which is applied in the field of pharmaceutical excipients, can solve problems such as the unsatisfactory moisture-proof effect of traditional Chinese medicine tablets and the inability to completely solve the problem of moisture absorption of traditional Chinese medicine, so as to solve the problem of moisture absorption, enhance moisture-proof performance, and expand the scope of use Effect

Inactive Publication Date: 2012-12-12
TIANJIN PULLERSUN PHARMA AUXILIARY MATERIAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the mechanical properties of the film coating agents on the market are acceptable, the moisture-proof effect on traditional Chinese medicine tablets is not satisfactory, and it cannot completely solve the problem of moisture absorption of traditional Chinese medicine.

Method used

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  • Moistureproof film coating agent for traditional Chinese medicine tablets and preparation method thereof
  • Moistureproof film coating agent for traditional Chinese medicine tablets and preparation method thereof
  • Moistureproof film coating agent for traditional Chinese medicine tablets and preparation method thereof

Examples

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preparation example Construction

[0016] A preparation method of a moisture-proof film coating agent for traditional Chinese medicine tablets, comprising the following steps:

[0017] (1) Throw vinylpyrrolidone-vinyl acetate copolymer, 5-15 centipoise hypromellose, polyethylene glycol 6000, iron oxide, titanium dioxide and talc into a high-speed mixer at a speed of 2700 rpm Mix for 0.5 to 3 minutes; the speed of the high-speed mixer is 2700 rpm, and the mixing time is 0.5 to 3 minutes.

[0018] (2) Sprinkle Tween 80 evenly on the material in the high-speed mixer, and mix at a speed of 2700 rpm for 0.5-3 minutes to make a finished Chinese medicine tablet moisture-proof film coating agent.

Embodiment 1

[0020] A preparation method of a moisture-proof film coating agent for traditional Chinese medicine tablets, comprising:

[0021] (1) Weigh 20 parts of vinylpyrrolidone-vinyl acetate copolymer, 30 parts of hypromellose of 5-15 centipoise, 600020 parts of polyethylene glycol, 803 parts of Tween, iron oxide 10 parts, 17 parts of talcum powder;

[0022] (2) Put vinylpyrrolidone-vinyl acetate copolymer, 5-15 centipoise hypromellose, polyethylene glycol 6000, iron oxide, titanium dioxide and talcum powder into a high-speed mixer, at a speed of 2700 Mix for 2 minutes at rpm;

[0023] (3) Sprinkle Tween 80 evenly on the material in the high-speed mixer, and mix at a speed of 2700 rpm for 15 minutes to prepare a moisture-proof film coating agent for traditional Chinese medicine tablets.

Embodiment 2

[0025] (1) Weigh 50 parts of vinylpyrrolidone-vinyl acetate copolymer, 10 parts of hypromellose of 5-15 centipoise, 600010 parts of polyethylene glycol, 803 parts of Tween, and 10 parts of iron oxide according to the ratio of parts by mass. 17 parts and talcum powder;

[0026] (2) Put 5-15 centipoise of hypromellose, polyethylene glycol 6000, iron oxide, titanium dioxide and talc into a high-speed mixer, and mix for 2 minutes at a speed of 2700 rpm;

[0027] (3) Sprinkle Tween 80 evenly on the material in the high-speed mixer, and mix at a speed of 2700 rpm for 15 minutes to prepare a film coating agent for Chinese medicine tablets.

[0028] Using a conventional method, a kind of moisture-proof film-coating agent for Chinese medicine tablets of Example 1 and Example 2 is made into a solution, and sprayed on the surface of the Chinese medicine core to make a moisture-proof film-coated tablet. Then carry out the moisture-proof test: use the constant temperature and humidity box...

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Abstract

The invention relates to a moistureproof film coating agent for traditional Chinese medicine tablets and a preparation method thereof. The technical characteristic is that the film coating agent comprises the following components according to mass proportion: 20-50 portions of vinyl pyrrolidone-vinyl acetic ester copolymer, 10-30 portions of 5-15 centipoise hydroxypropyl methylcellulose, 10-20 portions of polyethylene glycol 6000, 1-5 portions of tween 80, 0-25 portions of ferric oxide, 0-20 portions of titanium dioxide and 0.1-30 portions of talc powder. The preparation method comprises the following steps: (1) the vinyl pyrrolidone-vinyl acetic ester copolymer, the 5-15 centipoise hydroxypropyl methylcellulose, the polyethylene glycol 6000, the ferric oxide, the titanium dioxide and the talc powder are put in a high-speed mixer for mixing; and (2) the tween 80 is evenly poured to and mixed with the materials in the high-speed mixer to prepare the finished products of moistureproof film coating agent for traditional Chinese medicine tablets. Various macromolecule film-forming materials are adopted to prepare the film coating agent, thus the moistureproof performance of traditional Chinese medicine tablets is enhanced, the problem of moisture absorption of traditional Chinese medicine is thoroughly resolved and the application range of film coating agent is enlarged.

Description

technical field [0001] The invention belongs to the field of pharmaceutical excipients, in particular to a traditional Chinese medicine tablet moisture-proof film coating agent and a preparation method thereof. Background technique [0002] Film coating agent is a kind of material for coating oral tablets, usually composed of film forming agent, plasticizer, auxiliary additive and coloring agent, when used, water or a mixture of water and ethanol is used as a solvent, sprayed on The surface of the drug core can form a smooth and uniform film coat, so that the drug core can avoid the erosion of light, oxygen, and moisture, and can beautify the appearance, improve the taste, and cover the odor. Compared with sugar coating, the film coating agent can save the coating operation time, and the performance of the tablet after coating is more stable. Although the film coating agents on the market have good mechanical properties, their moisture-proof effect on Chinese medicine table...

Claims

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Application Information

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IPC IPC(8): A61K47/38A61K47/34A61K47/32A61K47/26A61K47/04A61K47/02A61K9/36A61K47/10
Inventor 孙元秋姜楠
Owner TIANJIN PULLERSUN PHARMA AUXILIARY MATERIAL
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