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Microdialysis device for improving recovery rate of non-polar medicine

A recovery, microdialysis technology, applied in the preparation of test samples, etc., can solve the problems of low sensitivity, limited detection, difficult detection, etc., and achieve the effect of wide and complete application fields and application promotion.

Inactive Publication Date: 2012-12-05
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since the perfusate used in microdialysis experiments is an aqueous solution with similar body fluid composition, non-polar substances show low recovery and low sensitivity
Therefore, microdialysis experiments are not suitable for sampling and monitoring of non-polar substances or drugs
However, a large part of the current drugs have strong non-polarity, which limits the detection of these drugs by microdialysis technology, thereby reducing the application range of microdialysis technology.
In the in vitro microdialysis experiments of three lipophilic drugs by Lotte Groth et al., the relative recovery rates of microdialysis were all less than 40%, and the stronger the lipophilicity of the drug, the lower the relative recovery rate; The in vitro relative recovery rate of lipid psoralen, the most fat-soluble trimethylpsoralen has no recovery rate at all, while the other two have only about 30% recovery rate under optimal dialysis conditions; Markus Müller et al. The transdermal transport of drugs was investigated by microdialysis, in which the recovery rate of estradiol, which is highly fat-soluble, was only 9% in vitro and as low as 2±1% in vivo, making it difficult to detect

Method used

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Effect test

Embodiment 1

[0013] A microdialysis device for improving the recovery rate of non-polar drugs, comprising a polyethylene material introduction tube with a length of 20 cm, an outer diameter of 1 mm, and an inner diameter of 0.8 mm, and one end of the introduction tube is connected with a length of 2 cm. , an internal diameter of 1mm is a connecting tube made of Teflon, and the other end of the connecting tube is tightly connected with a polyvinylidene fluoride hollow fiber membrane with an outer diameter of 1 mm and a membrane hole of 0.1 μm and a length of 2 cm. The other end of the fiber membrane is blocked with AB glue; a capillary tube with a length of 14 cm and a specification of 350 / 250 μm runs through and is tightly sealed on the tube wall of the connecting tube as the outlet tube. The microdialysis device uses n-octanol as the perfusate.

Embodiment 2

[0015] A microdialysis device for improving the recovery rate of non-polar drugs, comprising a polyethylene material introduction tube with a length of 10 cm, an outer diameter of 1 mm, and an inner diameter of 0.5 mm. One end of the introduction tube is connected with a 3 cm long , an inner diameter of 1mm is a connecting tube made of Teflon, and the other end of the connecting tube is tightly connected with a polyvinylidene fluoride hollow fiber membrane with an outer diameter of 1 mm and a membrane hole of 0.1 μm and a length of 0.5 cm. The other end of the hollow fiber membrane is blocked with AB glue; a capillary tube with a length of 10 cm and a specification of 350 / 250 μm runs through and is tightly sealed on the tube wall of the connecting tube as the outlet tube, which improves the recovery rate of non-polar drugs. The microdialysis device used n-octanol as the perfusate.

Embodiment 3

[0017] A microdialysis device for improving the recovery rate of non-polar drugs, comprising a polyethylene material introduction tube with a length of 15cm, an outer diameter of 1mm, and an inner diameter of 0.7mm, and one end of the introduction tube is connected with a 4cm long , an inner diameter of 1mm is a connecting tube made of Teflon, and the other end of the connecting tube is tightly connected with a polyvinylidene fluoride hollow fiber membrane with an outer diameter of 1 mm and a membrane hole of 0.1 μm and a length of 3 cm. The other end of the fiber membrane is blocked with AB glue; a capillary tube with a length of 20 cm and a specification of 350 / 250 μm runs through and is tightly sealed on the tube wall of the connecting tube as the outlet tube. The microdialysis device uses n-octanol as the perfusate.

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Abstract

The invention discloses a microdialysis device for improving recovery rate of non-polar medicine. The microdialysis device comprises a polyethylene lead-in tube with an outer diameter of 1mm and an inner diameter of 0.5-0.8mm, wherein one end of the lead-in tube is connected with a teflon connecting tube of which the inner diameter is 1mm; the other end of the connecting tube is tightly connected with a polyvinylidene fluoride hollow fiber membrane of which the outer diameter is 1mm and the membrane pore is 0.1mum; the other end of the hollow fiber membrane is sealed by AB adhesive; a capillary tube with length of 10-50cm and specification of 350 / 250mum serving as a lead-out tube runs through and is arranged on the wall of the connecting pipe in a tightly sealing way; and according to the microdialysis device for improving the recovery rate of the non-polar medicine, n-caprylic alcohol or dodecane is taken as perfusate. By the microdialysis device, the problem of low recovery rate of the non-polar medicine can be smoothly solved, and pharmacokinetics parameters of the non-polar medicine can be determined by a method disclosed by the invention. The application of a microdialysis technology to the non-polar medicine is expanded.

Description

technical field [0001] The invention relates to a device for improving the recovery rate of nonpolar drugs. Background technique [0002] Microdialysis technology (Microdialysis, MD) is a kind of combination of perfusion sampling and dialysis technology, and gradually perfected a new technology for dynamic trace biochemical sampling from living organisms. From the rudimentary form in the mid-1960s, it gradually improved and expanded its scope of application. Microdialysis technology has the characteristics of continuous sampling, quantitative analysis, dynamic observation, small sampling volume, and light tissue damage. It has become one of the important research tools for pharmacokinetics, neurophysiology and neurochemistry. Since the perfusate used in microdialysis experiments is an aqueous solution with similar components to body fluids, non-polar substances show low recovery rates and low sensitivity. Therefore, microdialysis experiments are not suitable for sampling a...

Claims

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Application Information

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IPC IPC(8): G01N1/34
Inventor 包建民李优鑫陈志丹闫晨蔡笑梅
Owner TIANJIN UNIV
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