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Compound pharmaceutical chemical acting on respiratory diseases and preparation process and application thereof

A technology for respiratory diseases and pharmaceutical preparations, which is applied in the field of pharmaceutical compositions using levopromazine and carbocisteine ​​as active ingredients, and can solve problems such as reducing the sensitivity of sensory nerves in the lungs

Active Publication Date: 2012-12-05
HUNAN JIUDIAN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, compound preparations containing dextromethorphan are facing a dilemma. Clinical trials have proved that ideal antitussives should reduce the sensitivity of sensory nerves in the lungs and block sensory nerve conduction in myelinated or unmyelinated nerves (such as local Anesthetics), but local anesthetics have side effects such as inhibiting lung defense reflexes and inducing bronchoconstriction

Method used

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  • Compound pharmaceutical chemical acting on respiratory diseases and preparation process and application thereof
  • Compound pharmaceutical chemical acting on respiratory diseases and preparation process and application thereof
  • Compound pharmaceutical chemical acting on respiratory diseases and preparation process and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Take by weighing levodropropizine 60g, carbocisteine ​​250g, be prepared into common oral tablet as follows:

[0044] Weigh 400g of starch, 20g of microcrystalline cellulose, 10g of polyvinylpyrrolidone, 5g of talcum powder and 20g of aspartame, pulverize and sieve the raw and auxiliary materials respectively, and set aside. Dissolve the starch in water and add levodropropizine and carbocisteine ​​to grind into a paste, dry, crush, and sieve; then add other excipient fine powder and mix well, add an appropriate amount of gelatin slurry, granulate, and bake , granulated, compressed into tablets, and prepared into 1000 tablets of the present invention.

Embodiment 2

[0046] Take levodropropizine 100g, carbocisteine ​​150g, prepare oral liquid as follows:

[0047] Grind levodropropizine and carbocisteine ​​respectively, sieve and mix evenly, add ethanol to the mixture, stir and dissolve, dissolve in about 500ml purified water, filter, adjust its pH to 8~9, add appropriate amount of sucrose, sorbic acid and methylparaben again, and add water to 1000ml, obtain the pharmaceutical composition oral liquid 1000ml of the present invention.

Embodiment 3

[0049]Take by weighing levodropropizine 10g, carbocisteine ​​200g appropriate amount, be prepared into capsules as follows:

[0050] Weigh 50g of starch, 10g of micropowder silica gel, 5g of magnesium stearate, 10g of pregelatinized starch and 10g of low-substituted hydroxymethylcellulose, pulverize levodropropizine and carbocisteine ​​respectively, sieve and mix evenly, Dissolve starch in water and add levodropropizine and carbocisteine ​​to grind into a paste, dry, crush, and sieve; then add other excipient fine powder and mix well, add appropriate amount of gelatin slurry, granulate, and bake , whole grain, and filling gelatin capsules to obtain 1000 capsules of the pharmaceutical composition of the present invention.

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Abstract

The invention provides pharmaceutical composition for respiratory diseases and a preparation process thereof, in particular to pharmaceutical composition and a preparation process and application thereof. The pharmaceutical composition comprises active ingredients, namely levodropropizine and carbocysteine, and pharmaceutically acceptable accessories. Compared with commonly used existing antitussive drugs or expectorants in the market, the pharmaceutical composition has more evident effect of cough relieving and fewer adverse reactions and has certain social benefit and economic benefit.

Description

field of invention [0001] The invention belongs to the field of chemical medicines, and relates to a pharmaceutical composition for antitussive and expectorant and its preparation process and application, in particular to a pharmaceutical composition with levodropropizine and carbocisteine ​​as active ingredients. Background technique [0002] With the development of modern industry, air pollution is becoming more and more serious, and the incidence of respiratory diseases is increasing day by day. The main clinical symptoms are cough, phlegm, and wheezing. Therefore, the treatment of respiratory diseases also needs to treat the causes and symptoms. Mild and infrequent cough, as long as the sputum or foreign matter can be discharged, it can be relieved naturally without medication. However, excessive severe cough, if not treated, will seriously affect people's life, work and rest, not only increase the pain of patients, affect rest and sleep, increase physical exertion, and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/495A61K31/198A61P11/00A61P11/14A61P11/10
CPCA61K47/26A61K31/495A61K9/2059A61K9/48A61K31/197A61K9/1658A61K9/2054A61K9/0095A61K9/2027A61K9/2063A61K9/1652A61K9/20A61K31/198A61P11/00A61P11/10A61P11/12A61P11/14A61K2300/00A61K9/08
Inventor 朱志宏卜振军杨静
Owner HUNAN JIUDIAN PHARMA
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