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A method for rapid detection of the content of index components in traditional Chinese medicinal materials by using near-infrared spectroscopy

A technology of near-infrared spectroscopy and traditional Chinese medicinal materials, which is applied in the field of medicine, can solve the problems of cumbersome inspection process, inability to meet the needs of the modern development of traditional Chinese medicine pharmaceuticals, and low technical level

Inactive Publication Date: 2011-12-21
HENAN UNIV OF CHINESE MEDICINE
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Problems solved by technology

[0002] Traditional Chinese medicine is the treasure of our Chinese nation, but due to its wide variety, different sources of medicinal materials, origins, growth years, harvest seasons, processing methods, especially artificial counterfeiting, and chemical drugs, etc., all affect the quality of traditional Chinese medicine. The original medicinal materials in circulation have different authenticity, quality and quality; conventional quality evaluation methods have complex sample processing process, cumbersome inspection process, high cost, and low efficiency, which cannot meet the needs of the modern development of traditional Chinese medicine pharmaceuticals, and are often controlled by a single index component The quality of traditional Chinese medicine cannot reflect the complexity of the ingredients of traditional Chinese medicine and its overall internal quality; and most of the existing detection methods are offline detection, which has the disadvantage of lagging behind in production
These have led to the low technical level of my country's traditional Chinese medicine pharmaceutical industry, and the lack of feasible quality control methods in the production process

Method used

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  • A method for rapid detection of the content of index components in traditional Chinese medicinal materials by using near-infrared spectroscopy
  • A method for rapid detection of the content of index components in traditional Chinese medicinal materials by using near-infrared spectroscopy
  • A method for rapid detection of the content of index components in traditional Chinese medicinal materials by using near-infrared spectroscopy

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Embodiment 1

[0036] Said Chinese medicinal material is Scutellaria baicalensis, and its near-infrared spectroscopy technique is used to determine the content of the Scutellaria baicalensis index components by the following steps:

[0037] (1) Near-infrared spectrum collection of Scutellaria baicalensis

[0038] A Nicolet 6700 near-infrared spectrometer equipped with an InGaAs detector, an external integrating sphere, a sample rotator, and OMNIC spectral signal acquisition software and TQ data processing software was used to analyze 113 Scutellaria baicalensis from different origins, varieties, and harvesting seasons. Medicinal materials are used as samples, scanned to obtain spectral data, the method is:

[0039] After drying 113 parts of Scutellaria baicalensis medicinal materials, crush them through a 100-mesh sieve, take 5g of the sample powder and put it into a quartz sample rotating cup, mix it evenly, and gently flatten it. Scanning, relative humidity: 40% to 50%, collect the near-i...

Embodiment 2

[0072] Said Chinese medicinal material is forsythia, and its index component content is determined by near-infrared spectroscopy by the following steps:

[0073] (1) Near-infrared spectrum collection of forsythia medicinal materials

[0074] A Nicolet 6700 near-infrared spectrometer equipped with an InGaAs detector, an external integrating sphere, a sample rotator, and OMNIC spectral signal acquisition software and TQ data processing software, 100 copies of Forsythia from different origins, varieties, and harvesting seasons across the country Medicinal materials are used as samples, scanned to obtain spectral data, the method is:

[0075] After drying 100 parts of forsythia medicinal materials, crush them through a 24-mesh sieve, take 5g sample powder and put it into a quartz sample rotating cup, mix evenly, flatten gently, use the diffuse reflectance of the integrating sphere and OMNIC spectral signal acquisition software, Scan, relative humidity: 35%, collect the near-infra...

Embodiment 3

[0086] Said Chinese medicinal material is yam, and its near-infrared spectroscopy technique is realized by the following steps to the content determination of yam index component:

[0087] (1) Collection of near-infrared spectra of yam medicinal materials:

[0088] A Nicolet 6700 near-infrared spectrometer equipped with an InGaAs detector, an external integrating sphere, a sample rotator, and OMNIC spectral signal acquisition software and TQ data processing software collected 115 yam medicinal materials from different varieties, different origins, and different harvest seasons As a sample, scan to obtain spectral data, the method is:

[0089] After drying 115 parts of yam medicinal materials, crush them through a 100-mesh sieve, take 5g of sample powder and put it into a quartz sample rotating cup, mix evenly, spread the medicinal powder with a thickness of 2 to 5cm, and use the diffuse reflectance of the integrating sphere and OMNIC spectral signal acquisition Software, scan...

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Abstract

The invention relates to a method for rapidly detecting the content of index components of Chinese medicinal materials by using near-infrared spectroscopy technology, which can realize the rapid detection of the comprehensive quality of Chinese medicinal materials. Collect the sample, collect the near-infrared diffuse reflectance spectrum of the sample, and preprocess the obtained spectrum, then use the detection method corresponding to the sample in the conventional method to measure the content of its index components, and combine the spectrum with the content of the index components, The quantitative analysis model is established by adopting the chemometrics method suitable for the analysis of the components of traditional Chinese medicine, the sample to be tested is crushed, and its near-infrared spectrum is scanned, and the spectrum is input into the quantitative analysis model to measure the content of the index components in the Chinese medicinal material. The whole process takes a short time, is fast and accurate, can be measured online, improves production efficiency, greatly saves manpower and material resources, and can generate huge economic and social benefits.

Description

1. Technical field [0001] The invention relates to the field of medicine, in particular to a method for rapidly detecting the contents of index components of traditional Chinese medicinal materials by using near-infrared spectroscopy. 2. Background technology [0002] Traditional Chinese medicine is the treasure of our Chinese nation, but due to its wide variety, different sources of medicinal materials, origins, growth years, harvest seasons, processing methods, especially artificial counterfeiting, and chemical drugs, etc., all affect the quality of traditional Chinese medicine. The original medicinal materials in circulation are different in authenticity, quality and quality; conventional quality evaluation methods have complex sample processing process, cumbersome inspection process, high cost, and low efficiency, which cannot meet the needs of the modern development of traditional Chinese medicine pharmaceuticals, and are often controlled by a single index component The...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/35G01N21/359
Inventor 白雁雷敬卫谢彩侠龚海燕宋瑞丽樊克峰李艳英陈志红王星
Owner HENAN UNIV OF CHINESE MEDICINE
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