Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Protopanoxadiol peroxide derivatives as well as preparation method and application thereof

A technology of peroxidation of panaxadiol and protopanaxadiol, which is applied in the field of biomedicine, can solve the problems of few reaction sites, difficulty in preparing derivatives, lack of active groups, etc., and achieves the effect of good antitumor activity

Active Publication Date: 2012-11-07
三蚁科技(广州)有限公司
View PDF5 Cites 14 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, protopanaxadiol belongs to tetracyclic triterpenoids, lacks active groups, and has few reaction sites. It is difficult to prepare derivatives that meet the requirements by conventional chemical reaction methods.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Protopanoxadiol peroxide derivatives as well as preparation method and application thereof
  • Protopanoxadiol peroxide derivatives as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1, preparation of protopanaxadiol peroxidized derivatives of formula I, formula II and formula III of the present invention

[0022] The invention adopts a microbial transformation method, uses protopanaxadiol as a raw material, and undergoes steps such as fermentation, extraction, and separation to prepare the compound of the invention. Microorganisms capable of transformation include: Absidia ( Absidia ), Xiaogram silvery mildew ( Cunninghamella ), Mucor ( Mucor ), Alternaria ( Alternaria ), Acremonium ( Acremonium ), red yeast ( Rhodotorula ), Syncephalum ( Syncephalastrum ), Aspergillus ( Aspergillus ) or Rhizopus ( Rhizopus ) of the genus of microorganisms, among which Absidia mould( Absidia ), Acremonium ( Acremonium ), Rhizopus ( Rhizopus ), Aspergillus ( Aspergillus ) or Mucor ( Mucor ) strains of the genus. These strains can be purchased from the Chinese Academy of Sciences Microbial Culture Collection Center (CGMCC) or the C...

Embodiment 2

[0045] Example 2 Antitumor Activity of Protopanaxadiol Peroxidized Derivatives of Formula I, Formula II and Formula III

[0046] 1) Experimental materials

[0047] Instruments and reagents: CO 2 Incubator (Jouan IGO150); Microplate reader (Bio-TEK ELx800); Fluorescence inverted microscope (Olympus IX51); MTT cell proliferation and cytotoxicity detection kit (Biotech Institute), RPM I 1640 medium (Gibcol BRL), RNase A, fetal bovine serum, dimethyl sulfoxide (DMSO), trypsin (Shanghai Bioengineering Co., Ltd.).

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a protopanoxadiol peroxide derivatives as well as a preparation method and an application of the protopanoxadiol peroxide derivatives. The structural formulae of the protopanoxadiol peroxide derivatives disclosed by the invention are shown in formulae I, II and III. In the method, the microbial conversion technology is utilized to modify structure of protopanoxadiol successfully so as to obtain various novel compounds. In-vitro anti-tumor cell test shows that the compounds have better anti-tumor activity, so that the compounds can be used as active components of the anti-tumor drug and have wide application.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a protopanaxadiol peroxidized derivative, a preparation method thereof, and a medical application of the derivative. Background technique [0002] Malignant tumors are one of the major diseases that endanger human health. The research and development of anti-tumor drugs has always been an important research content in the field of medicine. Natural products have always been the source of human beings looking for effective active ingredients. In the process of new drug development, on the one hand, natural products with good activity can be directly used clinically; Finding and developing new high-efficiency and low-toxic drugs by means of modification is one of the most effective ways to develop new drugs that has been proven in practice. At present, most of the mainstream anti-tumor drugs commonly used in clinical practice are derived from natural medicines, or products obtained afte...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07J9/00A61K31/575A61P35/00C12P33/00C12R1/65C12R1/785C12R1/845C12R1/685C12R1/645
Inventor 陈广通杨雪凌勇翟旭光
Owner 三蚁科技(广州)有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com