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Method for preparing quick-responding thermo-sensitive porous microspheres based on microfluidic technology

A microfluidic technology and fast response technology, applied in the field of preparation of temperature-sensitive porous microspheres, can solve problems such as uneven particle size of microspheres, and achieve adjustable temperature response time, controllable size, and adjustable shrinkage volume ratio control effect

Inactive Publication Date: 2012-10-31
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These technical methods can simply synthesize hydrogel microspheres with phase transition temperature, but the particle size of the formed microspheres is not uniform

Method used

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  • Method for preparing quick-responding thermo-sensitive porous microspheres based on microfluidic technology
  • Method for preparing quick-responding thermo-sensitive porous microspheres based on microfluidic technology
  • Method for preparing quick-responding thermo-sensitive porous microspheres based on microfluidic technology

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Preparation of blank temperature-sensitive microspheres: the microfluidic chip used in the preparation, its structure is as follows figure 1As shown, the monomer injection pool 2 and the initiator injection pool 3 are connected together through a microfluidic channel, and communicate with the microdroplet formation and polymerization channel 4, and the outer oil phase injection pool 1 is connected through a ring microfluidic channel. The control channel is connected with the micro-droplet formation and polymerization channel 4, and finally the micro-droplet formation and polymerization channel 4 is connected with the collection pool 5 located at the other end of the microfluidic control chip. First, the upper microfluidic chip is prepared by soft lithography technology, and the upper PDMS microfluidic chip and the lower substrate are irreversibly sealed together by oxygen plasma. The surface of the channel is then modified by hydrophobization to enable the formation of ...

Embodiment 2

[0036] Preparation of porous temperature-sensitive microspheres formed by polyethylene glycol 1,000 molecules at a concentration of 1:1 (polyethylene glycol 1,000: N-isopropylacrylamide), based on the microfluidic chip produced in Example 1 Proceed: Add 1,000 molecules of polyethylene glycol to the monomer solution, and its mass is twice that of N-isopropylacrylamide. Add 0.4 g of polyethylene glycol 1,000 to it, and dissolve it as a monomer solution. Among them, the flow rate of the monomer and initiator was adjusted to 0.5 μL / min, and the flow rate of the oil phase (FC-40) was adjusted to 1.2 μL / min. The synthesized microspheres were taken out from the collection pool 5, and then soaked in deionized water for 3 day, and change the water at regular intervals to remove the polyethylene glycol molecules dissolved from the microspheres, and the obtained porous thermosensitive microspheres are investigated in the same way as above for thermosensitive properties (such as Figure ...

Embodiment 3

[0039] Prepare different fast-response temperature-sensitive porous microspheres with the same molecular weight and different concentrations of polyethylene glycol: on the basis of Example 2, 10,000 molecules of polyethylene glycol with 3 different concentrations were added to the monomer solution, which was mixed with N- The mass ratios of isopropylacrylamide are 0.5:1, 1:1, and 2:1, that is, when a 1mL solution is prepared, 0.2g of N-isopropylacrylamide, 0.1g, 0.2g, and 0.4 g Polyethylene glycol 10,000 molecules. When synthesizing microspheres, adjust the concentration of monomer and initiator to 0.5 μL / min, and the flow rate of the oil phase (FC-40) to 1 μL / min. Soak in water for 3 days, and change the water in stages to remove polyethylene glycol molecules of different concentrations, and investigate the temperature-sensitive properties of the prepared porous microspheres (such as Figure 6 and Figure 7 shown) and electron microscope scanning of the surface topography (...

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Abstract

The invention provides a method for preparing quick-responding thermo-sensitive porous microspheres based on the microfluidic technology. A microfluidic chip used mainly comprises a polymer or a glass chip with a microchannel on the upper layer and a sealing substrate on the lower layer. The method includes firstly, forming oil-in-water micro-droplets (w / o) in the microfluidic chip by the droplet control technology, polymerizing the micro-droplets to form microspheres during moving or collecting process; and adding pore-forming agent polyethylene glycol in a water phase to control different porous morphologies of the microspheres so that different temperature response characteristics. The method for preparing the quick-responding thermo-sensitive porous microspheres based on the microfluidic technology has the advantages that the chip structure is simple to manufacture, the method is highly controllable and easy to operate, particle size of the microspheres prepared by the microfluidic technology is uniform and controllable, micro-pores on the surfaces of the microspheres are controllable are controllable in size, the method has the quick-responding thermo-sensitive characteristics and has wide potential application range, and the like.

Description

technical field [0001] The invention relates to a method for preparing hydrogel microspheres, in particular to a method for preparing temperature-sensitive porous microspheres based on microfluidic technology. Background technique [0002] Thermosensitive hydrogels are a type of gel whose swelling ratio changes suddenly (phase transition) at a certain temperature, and the temperature at which the swelling ratio changes suddenly is called the phase transition temperature. [0003] At present, the technologies used to synthesize hydrogel microspheres mainly include selective solvent evaporation method, extraction method, microemulsion polymerization method, radiation precipitation polymerization method, polymer dilute solution irradiation method, etc. These technical methods can simply synthesize hydrogel microspheres with a phase transition temperature, but the particle size of the formed microspheres is not uniform. Microfluidic technology has become the preferred technolog...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F20/54C08F2/32C08F2/48C08F2/01C08J9/28C08J9/26B01J13/14
Inventor 秦建华黄术强姜雷
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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