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Medicinal composition used for treating fatty liver and quality detection method thereof

A quality inspection method and composition technology, which can be used in drug combinations, pharmaceutical formulations, measuring devices, etc., and can solve problems such as many adverse reactions, insufficient patient compliance, and limited clinical application.

Active Publication Date: 2012-09-26
ZHANGZHOU PIEN TZE HUANG PHARM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the intervention of reasonable diet, alcohol prohibition and increased exercise is more effective in the treatment of fatty liver, but the patient's compliance is not enough
Clinically, there is still a lack of anti-fatty liver drugs with ideal curative effect. Although the reported drugs such as cholestyramine, inositol nicotinate, bezafibrate, and gemfibrozil can inhibit fatty liver from different links, their adverse reactions Many, long course of treatment, so the clinical application is limited

Method used

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  • Medicinal composition used for treating fatty liver and quality detection method thereof
  • Medicinal composition used for treating fatty liver and quality detection method thereof
  • Medicinal composition used for treating fatty liver and quality detection method thereof

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0040] Experimental example 1 Comparative test of the drug effect of the composition preparation of the present invention on experimental fatty liver in rats

[0041] 1. Experimental purpose: to observe the effect of the composition preparation of the present invention on the rat fatty liver (FLD) model, and to provide a pharmacodynamic experiment basis for the composition preparation of the present invention to prevent and treat fatty liver.

[0042] 2. Experimental materials:

[0043] (1) Experimental animals: clean grade white rats, SD, ♂, 120-140g, 110, certificate of conformity: 0023665, Shanghai Slack Experimental Animal Co., Ltd.

[0044] (2) Test drugs:

[0045] Composition tablet of the present invention (trade name: Pien Tze Huang Ganbao, prepared according to the method in Example 1): unprepared raw powder, in yellowish brown granules, containing 2.916g of crude drug per gram, batch number: 0608001. Prepared with distilled water during the test.

[0046] (3) Oth...

Embodiment 1

[0127] Embodiment 1 tablet of the present invention

[0128] Formula: capillary 150g, gentian 120g, gardenia 50g, rhubarb 10g, white peony 30g, licorice 30g, notoginseng 42.5g, snake gallbladder 3.5g, bezoar 2.5g, artificial musk 1.5g.

[0129] Preparation method:

[0130] A. Take rhubarb, white peony root and notoginseng and grind them into fine powder 1, take snake gallbladder, bezoar and artificial musk and grind them into fine powder 2,

[0131] B. Take capillary, gentian, gardenia, licorice and other four medicinal materials and add water to extract twice, each time for 2 hours (8 times the amount in the first time, 6 times the amount in the second time), filter, combine the filtrate and concentrate to relative density 1.200-1.230 (heat measurement 40°C-50°C), add ethanol to make the liquid alcohol content reach 70%, let it stand, take the supernatant, recover ethanol and continue to concentrate to a relative density of 1.25-1.30 (heat measurement 90 ℃-100℃) thick p...

Embodiment 2

[0134] Embodiment 2 powder of the present invention

[0135] Formula: capillary 60g, gentian 190g, gardenia 18g, rhubarb 16g, white peony root 12g, licorice 48g, notoginseng 15g, snake gallbladder 6g, bezoar 1g, artificial musk 2.5g.

[0136] The above-mentioned medicine is added into conventional auxiliary materials, and according to the conventional process, it is made into a powder, each serving 1g, three times a day.

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PUM

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Abstract

The invention discloses a quality detection method of medicinal composition used for treating fatty liver. Raw materials are screened, the identified medicinal materials are selected, a determination and identification method adopts a thin layer chromatography test, ethyl acetate-methyl alcohol-water (20: 2: 1) is taken as a developer, and experimental results show that sample spots are clear, separation effect is good and no interference is produced in negative control. The raw materials of the medicinal composition are as follows in parts by weight: 50-250 parts of oriental wormwood, 40-200 parts of rough gentian, 15-85 parts of jasmine, 3-18 parts of rheum offcinale, 10-50 parts of white paeony root, 10-50 parts of liquorice, 14-70 parts of pseudo ginseng, 1-6 parts of snake gall, 1-4 parts of bezoar and 0.5-2.5 parts of muscone.

Description

technical field [0001] The invention relates to a pharmaceutical composition and its preparation, preparation method and quality detection method, in particular to a pharmaceutical composition for treating fatty liver and its preparation, preparation method and quality detection method, belonging to the technical field of pharmacy. Background technique [0002] In recent years, with the continuous improvement of people's living standards and changes in dietary structure, the incidence of fatty liver has shown an obvious upward trend. The pathogenesis of fatty liver is mainly related to abnormal liver lipid metabolism, obesity, long-term heavy drinking, diabetes, viral hepatitis, etc., and can gradually develop into end-stage liver diseases such as liver cirrhosis and liver cancer. At present, the intervention of reasonable diet, alcohol prohibition, and increased exercise is more effective in the treatment of fatty liver, but the patient's compliance is not enough. Clinical...

Claims

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Application Information

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IPC IPC(8): G01N30/90A61K36/744A61P1/16
Inventor 潘杰黄进明于娟洪绯
Owner ZHANGZHOU PIEN TZE HUANG PHARM
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