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Medical biology degradable magnesium alloy composite material

A technology of biodegradable materials and composite materials, which is applied in the field of medical biodegradable magnesium alloy composite materials, can solve problems such as damage to the integrity of the magnesium oxide surface film, application limitations, and increased corrosion, so as to prolong the degradable time and reduce tissue damage , The effect of low porosity

Inactive Publication Date: 2012-09-05
吉林金源北方科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although magnesium and magnesium alloys have the above-mentioned advantages, their application as biomaterials is largely limited. The main reason is that the chemical properties of magnesium are extremely active. Good protection, the corrosion process is also accompanied by a large amount of hydrogen generation
Especially in the corrosive medium containing chloride ions, the integrity of the magnesium oxide surface film will be destroyed, resulting in increased corrosion
[0005] At present, there are many research results on medical degradable materials in the field of orthopedic implants, and a large number of documents and patents have also been produced, but they all have a common problem. The use of magnesium alloy materials alone cannot solve the problem of excessive degradation. However, the use of medical biopolymer materials alone cannot solve the problem of insufficient strength.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0016] First prepare a magnesium alloy sample bar with a length of 30 mm, a width of 4 mm, and a thickness of 1 mm. A hole with a diameter of 2 mm is punched at each end to form a bone plate shape, and then the purified biodegradable carbon dioxide copolymer is treated with dimethyl carbonate. Dissolve the ester, prepare a solution, spray it on the surface of the bone plate with a spray gun, and put it in an oven to dry. The thickness of the test coating is about 0.02mm. The prepared sample is implanted in the leg bone of the animal for observation. After 6 months There is basically no change over time, the main degradation process starts at 12 months, and the magnesium alloy material is basically degraded in about 2-3 months, leaving a small amount of carbon dioxide copolymer material.

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Abstract

The invention relates to a novel degradable medical magnesium alloy composite material. The medical magnesium alloy composite material provided by the invention has the characteristics of high strength, good temperature memory and controllable degradation velocity and can be used in the field of orthopedic implantation. The composite material is characterized in that the composite material contains Mg-Al-Zn magnesium alloys, wherein the content of Al is 0.5-3.5wt% and the content of Zn is 0.5-1.8wt%; besides, the magnesium alloy material can contain a few impurities including Fe, Mn, Cu and Ni, wherein the total of the impurities is not greater than 0.3wt%; and a medical biology degradable material exists on the surface layer of the composite material and can be a pure carbon dioxide copolymer, pure polyhydroxyalkanoate or a blend of the carbon dioxide copolymer and polyhydroxyalkanoate, which has to be medically purified before use.

Description

Technical field: [0001] The invention relates to a medical biodegradable magnesium alloy composite material, the interior of which is a medical magnesium alloy material, and the surface layer is a medical biodegradable material. Bonded together by coating or injection molding process. technical background: [0002] Magnesium alloy has the characteristics of high specific strength, low density and good biocompatibility. It has great potential as a medical biomaterial. The poor corrosion resistance of magnesium alloy limits its wide application in other fields, but it can be used in many fields. Biomedical materials that safely degrade in the human body create new uses. After the magnesium alloy medical device is implanted into the human body, the implanted device will gradually degrade until it disappears as the injured tissue heals. However, the existing magnesium alloys degrade and corrode too fast in the human body, which needs further control. How to control the degrad...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/06A61L27/34A61L27/40C22C23/02C22C23/04
Inventor 冯超
Owner 吉林金源北方科技发展有限公司
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