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Method for inspecting quality of Gueldenstaedtia delavayi Franch.

A technology for skin cold medicine and medicinal materials, which is applied in the field of detecting the quality of skin cold medicines, can solve the problems such as no quality detection method of skin cold medicine, and achieves the effects of good efficacy, good reproducibility and quality control.

Inactive Publication Date: 2012-08-22
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is no report on the active ingredients in the skin cold medicine, and there is no quality detection method for the skin cold medicine

Method used

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  • Method for inspecting quality of Gueldenstaedtia delavayi Franch.
  • Method for inspecting quality of Gueldenstaedtia delavayi Franch.
  • Method for inspecting quality of Gueldenstaedtia delavayi Franch.

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Embodiment 1

[0026] Chemical composition identification in embodiment 1 skin cold medicine

[0027] 1 Instruments, reagents

[0028] Superconducting high-resolution nuclear magnetic resonance spectrometer: Bruker Avance 600 probe: 13C-1H DUL TE: 300K

[0029] High resolution mass spectrometer: Micromass Zabspec

[0030] Column chromatography packing: silica gel H (200-300 mesh), Qingdao Ocean Chemical Factory;

[0031] Chromatographic silica gel plate: HPTLC plate, Qingdao Ocean Chemical Factory;

[0032] Thin layer chromatography (TLC) silica gel: silica gel G, silica gel GF-254, Qingdao Ocean Chemical Factory;

[0033] Chromatographic solvent system: petroleum ether: acetone (different ratios); chloroform: acetone (different ratios); dichloromethane: methanol (different ratios); dichloromethane: ethyl acetate (different ratios);

[0034] TLC developer: 10% sulfuric acid ethanol solution; iodine vapor; ultraviolet lamp (254nm, 365nm);

[0035] All solvents used were of analytical gra...

Embodiment 2

[0056] Example 2 Screening of skin cold medicine medicinal material detection method

[0057] For the first time in the present invention, it is found that the skin cold medicine contains chemical components such as formononetin and sophorin Brain, daidzein 4′–methyl ether [1] , is a flavonoid component. Modern research shows that formononetin has estrogen-like effects [2、3] ,Anti-oxidize effect [4] , can significantly promote the non-specific immune system [5] , anticancer effect [6] , as well as hypolipidemic, diuretic [7] And so on. Sophorin, also known as macaine, Korean huaying, and sophorin, is a flavonoid component. Modern research shows that sophorin has antibacterial effect [8] , anti-tumor effect, has inhibitory effect on cAMP phosphodiesterase [9] .

[0058] The current research on skin cold medicine shows that the medicine can produce sweat, relieve the surface, dispel wind and dissipate heat, and can be used for exogenous fever, headache, dizziness, sore...

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Abstract

The invention discloses a method for inspecting quality of Gueldenstaedtia delavayi Franch. In the inspection method of the Gueldenstaedtia delavayi Franch., by screening a mobile phase under an isochromatic spectrum condition, the separation degree of Formononetin and maackiain chromatographic peaks is enabled to be good. Moreover, the determination method has good repeatability, is stable and reliable and is suitable for the determination of content of Formononetin and maackiain in the Gueldenstaedtia delavayi Franch. According to experiments, the Gueldenstaedtia delavayi Franch. which is inspected as acceptable by adopting the method has good pharmacological activity. The result clearly shows that the inspection method provided by the invention facilitates the realization of the quality control of the Gueldenstaedtia delavayi Franch.

Description

technical field [0001] The invention relates to a method for detecting the quality of skin-cold medicinal materials, belonging to the field of medicines. Background technique [0002] Skin cold medicine is a folk herbal medicine used to treat colds in the Anning River Basin of Panxi, Sichuan. The local people also call it "skin typhoid" and "chicken thigh". It comes from the Gueldenstaedtia delavayi Franch. Dried whole herb, whole herb used as medicine, can be harvested in four seasons; cold in nature, bitter in taste, clearing away heat, detoxifying and relieving pain. The term "skin cold medicine" first appeared in "Xichang Chinese Herbal Medicine", in which it is said that it is derived from the whole plant of Amblytropsis delavayi (Fr.) C.Y.Wu, a plant of the genus Papilionaceae. The Kangdian Rice Pocket is the Sichuan-Yunnan Rice Pocket Gueldenstaedtia delavayi Franch. recorded in Flora of China. However, skin cold medicine is not the same plant as the rice pocket Gue...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/88
Inventor 蒋桂华赵芙蓉陈孝雨彭腾宋岚邓晶晶杨莎陈佳妮兰群于忠强
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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