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Protopanaxatriol composition and application thereof to preparation of Parkinson resisting drugs

A technology of protopanaxatriol and ginsenoside, which is applied in the direction of drug combination, pharmaceutical formula, plant raw materials, etc., can solve the problems of high cost, complicated preparation process, and high toxicity, and achieve low production cost, simple preparation method, and reduced toxicity. side effects

Inactive Publication Date: 2012-08-15
LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Monomer saponins are generally more toxic, and the preparation process is more complicated and the cost is higher

Method used

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  • Protopanaxatriol composition and application thereof to preparation of Parkinson resisting drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1 Solubility in water of protopanaxatriol type saponins and protopanaxatriol group saponins

[0020] According to the 2010 edition of Pharmacopoeia (documentation), weigh the test sample that has been ground into a fine powder, and shake it vigorously for 30 seconds every 5 minutes in a solvent with a certain capacity at 25°C ± 2°C; observe the dissolution within 30 minutes, If there are no visible solute particles or droplets, it is considered to be completely dissolved. According to this method, the protopanaxatriol group saponin made by this laboratory is easily soluble, and the solubility is about 429mg / ml, and the solubility of ginsenoside-Re,-Rg1,-Rg2 and-Rh1 in water is about 1.2mg / ml, 0.9mg / ml, 0.4mg / ml and 0.3mg / ml.

Embodiment 2

[0022] Protopanaxatriol saponin composition is made by mixing 50% ginsenoside-Re and 50% ginsenoside-Rg1.

Embodiment 3

[0024] Protopanaxatriol saponin composition is composed of ginsenoside-Re 40%, ginsenoside-Rg 1 35%, Ginsenoside-Rg 2 15%, Ginsenoside-Rh 1 10% mixed preparation.

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Abstract

The invention discloses a panaxatriol saponins composition and application thereof to preparation of drugs for strengthening immunity. The panaxatriol saponins composition at least comprises 5-60% of ginsenoside-Re and 5-60% of ginsenoside-Rg1 by weight percent. The panaxatriol saponins composition has stronger activity than the single ginsenoside in resisting Parkinson's diseases and has high bioavailability, simple preparation method and low price.

Description

technical field [0001] The invention relates to a traditional Chinese medicine and its application, in particular to a pharmaceutical composition with protopanaxatriol group saponin as an active ingredient and its application in the preparation of anti-Parkinson medicine. Background technique [0002] Parkinson's disease (PD) is a central nervous system degenerative disease characterized by progressive death of dopaminergic neurons in the substantia nigra of the midbrain. At present, the main treatment method is western medicine, but it only improves the symptoms, but cannot control its progress, and the curative effect is weakened and the toxicity increases after long-term application. And Chinese medicine treatment has advantages such as little toxic and side effects, strong synergistic effect and more development prospects. Studies have shown that ginsenosides -Rg1, -Re, -Rg2 and their metabolites protopanaxatriol have anti-parkinsonian effects (1. Zhang Juntian. Neuron-...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/258A61K31/704A61P25/16A61K127/00A61K135/00
Inventor 窦德强李东微李冀康廷国
Owner LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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