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Quality detection method for spleen-invigorating, cold-dispersing and antidiarrheal medicine composition

A quality detection method, a technology of invigorating the spleen and warming the spleen, applied to measuring devices, instruments, scientific instruments, etc., can solve problems such as different thin-layer identification methods, poor product quality controllability, and large consumption of organic solvents, etc., to achieve reduction Effects of toxicity, reduction of manpower and material resources, and reduction of solvent consumption

Active Publication Date: 2012-08-01
YABAO PHARMA GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the existing quality standards, the identification items include microscopic identification, and TLC identification is carried out for cloves, cinnamon and longan; the inspection items are carried out in accordance with the relevant regulations under the IR ointment item in the first appendix of the 2000 edition of "Chinese Pharmacopoeia" inspection; in the content determination item, the content determination of eugenol in cloves has been carried out; but there are following deficiencies in the existing standards: in the thin layer identification item, cloves, cinnamon and longan thin layer identification methods are different, using different solvents, Different preparation methods lead to large consumption of organic solvents, pollute the environment, and take a long time to test; in the existing standards, there is only a method for determining the content of eugenol in cloves, which is poor in product quality controllability

Method used

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  • Quality detection method for spleen-invigorating, cold-dispersing and antidiarrheal medicine composition
  • Quality detection method for spleen-invigorating, cold-dispersing and antidiarrheal medicine composition
  • Quality detection method for spleen-invigorating, cold-dispersing and antidiarrheal medicine composition

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0218] Embodiment 1: plaster and detection method

[0219] Clove 670g, cinnamon 440g, longan 230g

[0220]The above three flavors, clove, cinnamon, and longan all take two-thirds of the amount. Grind into fine powder and sieve; decoct the remaining medicinal materials with water twice, the first time with 8 times the amount of water for 2 hours, the second time with 6 times the amount of water for 1.5 hours (while collecting volatile oil), filter, and combine the filtrates, Concentrate the filtrate to a clear paste with a relative density of 1.20-1.25 (60-65°C), dry it in vacuum to obtain a dry extract, and grind it into a very fine powder. Separately take 246g of vaseline, 16g of laurocaprazine, 16g of glycerin, and 50-55g of paraffin, heat it on a water bath, add the above-mentioned volatile oil and appropriate amount of lanolin after melting, grind it with the above-mentioned powder, let it cool, and press it with a mold to form 1000 stickers, pack and get.

[0221] Iden...

Embodiment 2

[0225] Embodiment 2: plaster and detection method

[0226] This product plaster is prepared by the method of embodiment 1;

[0227] Content determination method:

[0228] A, the content determination of cinnamon: measure according to high performance liquid chromatography;

[0229] Chromatographic conditions and system suitability test: Octadecylsilane bonded silica gel is used as filler; 50:50 methanol-water is used as mobile phase; detection wavelength is 290nm; theoretical plate number should not be less than 3000 based on cinnamaldehyde peak ;

[0230] Preparation of reference substance solution Take an appropriate amount of cinnamon aldehyde reference substance, accurately weigh it, add absolute ethanol to make a solution containing 40ug per 1ml, and get final product;

[0231] Preparation of the test solution Take 10 pastes of this product, remove the cover lining, cut into pieces, mix well, take 0.5g, accurately weigh it, put it in a brown Erlenmeyer bottle with a st...

Embodiment 3

[0238] Embodiment 3: detection method

[0239] Clove, cinnamon, Piper longum medicinal composition are prepared according to the method of embodiment 1;

[0240] Identification method: A. Grind the medicinal composition of cloves, cinnamon, and longan that invigorate the spleen, warm the middle, dispel cold and relieve diarrhea, grind finely, mix evenly, put 3.5g in a brown Erlenmeyer flask, add 15ml of absolute ethanol, and soak in cold Overnight, filter, and the filtrate is used as the test solution;

[0241] B. Identification of cloves: Take eugenol reference substance, add absolute ethanol to make a solution containing 16ul per 1ml, as the reference substance solution; test according to thin-layer chromatography, draw 3μl of each of the above two solutions, and spot on the same silica gel respectively On G thin-layer board, use 6:0.8 petroleum ether-ethyl acetate as developing agent, wherein the boiling point of petroleum ether is 60-90°C, develop, take out, dry in the ai...

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Abstract

The invention discloses a quality detection method for a spleen-invigorating, cold-dispersing and antidiarrheal medicine composition, which includes identification and content determination. The existing quality standard is raised, on one hand, a preparation method of thin-layer sample solution identification is simplified, solvent usage, pollution, labor and materials are reduced, and cost is saved; and on the other hand, content tests of cinnamon and fructus piperis longi are added, and by a series of inspection on specificity, linear relation, stability, repeatability and the like, the method conforms to Chinese Pharmacopoeia 2010, quality control in industrial production and quality stability of products are benefited.

Description

field of invention [0001] The invention relates to a detection method of a traditional Chinese medicine composition, in particular to a quality detection method of a traditional Chinese medicine composition for invigorating the spleen and warming the heart, dispelling cold and relieving diarrhea. Background technique [0002] The medicinal composition composed of clove, cinnamon and longan longan has the effects of invigorating the spleen and warming the middle, dispelling cold and relieving diarrhea. In the existing quality standards, the identification items include microscopic identification, and TLC identification is carried out for cloves, cinnamon and longan; the inspection items are carried out in accordance with the relevant regulations under the IR ointment item in the first appendix of the 2000 edition of "Chinese Pharmacopoeia" inspection; in the content determination item, the content determination of eugenol in cloves has been carried out; but there are followin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/90G01N30/02
Inventor 任武贤杨晓宁禹玉洪
Owner YABAO PHARMA GRP CO LTD
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