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Method for detecting Danhong injection ethanol precipitation process on line

A Danhong injection and detection method technology, applied in the direction of measuring device, color/spectral characteristic measurement, material analysis through optical means, etc., to achieve the effect of improving quality control level and stabilizing product quality

Active Publication Date: 2012-08-01
ZHEJIANG UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these patents all collect near-infrared spectra off-line, and do not actually apply the built model to online analysis

Method used

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  • Method for detecting Danhong injection ethanol precipitation process on line
  • Method for detecting Danhong injection ethanol precipitation process on line
  • Method for detecting Danhong injection ethanol precipitation process on line

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] 1. Install near-infrared online detection device

[0047] see figure 1 , the near-infrared on-line detection device is composed of the following parts: the near-infrared on-line detection system includes an alcohol precipitation tank 1, an agitator 2, a filter 3, a first peristaltic pump 4, a second peristaltic pump 4', a near-infrared spectrometer 5 , an optical fiber probe 6, a flow cell 7, a circulation pipeline 8 and an ethanol precipitation liquid sampling port 9. The filter 3 is placed in the alcohol precipitation tank 1, and is connected to the first peristaltic pump 4, the flow cell 7 and the alcohol precipitation liquid sampling port 9 through the circulation pipeline 8, and the second peristaltic pump 4' is connected to the alcohol precipitation tank 1 and the alcohol precipitation tank 1 through a pipeline. For ethanol solution, the near-infrared spectrometer 5 collects the near-infrared spectrum of the ethanol precipitation solution in the flow cell 7 onli...

Embodiment 2

[0065] According to the method of Example 1, the difference is that the quantitative correction model of each quality control index is established by using the least squares support vector machine (LS-SVM) algorithm.

[0066] 1. The same calibration set sample data as in Example 1 was selected.

[0067] The same method as in Example 1 was used to preprocess the near-infrared spectral data by the first derivative method (Savitzky-Golay smoothing) and the standard orthogonal transformation algorithm after removing the abnormal spectrum. For the soluble solids content model use 5445~7500 cm -1For the Danshensu, Protocatechualdehyde, Hydroxysafflower Yellow A and Salvianolic Acid B models, use 5445~6100 cm -1 band.

[0068] 2. The least squares support vector machine (LS-SVM) algorithm was used to establish the model of each quality control index

[0069] After obtaining the characteristic spectrum information of the alcohol precipitation liquid, the least squares support vec...

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Abstract

The invention provides a method for detecting a Danhong injection ethanol precipitation process on line. The method comprises the following steps of: (1) designing a near-infrared on-line detection system; (2) acquiring the near-infrared transmittance spectrums of Danhong injection ethanol precipitation liquid and an ethanol precipitation liquid sample; (3) acquiring quality control index information from the ethanol precipitation liquid sample by a high performance liquid chromatography and a drying weighing method; (4) rejecting abnormal spectrums; (5) selecting a near-infrared spectrum modeling wave band and a preprocessing method; (6) establishing quality control index models by a multielement correction algorithm, and inspecting the performance of the models by using model evaluating indexes; and (7) analyzing the variation trends of the quality control indexes in the ethanol precipitation process on line by using the established models. A near-infrared on-line detection technology is applied to the measurement of the content of chemical index components and soluble solid substances in the Danhong injection ethanol precipitation process, reference and effective guidance are provided for the on-line control over the Danhong injection ethanol precipitation process.

Description

technical field [0001] The invention belongs to the field of near-infrared on-line detection, and in particular relates to an on-line detection method for the alcohol precipitation process of Danhong injection. Background technique [0002] Danhong Injection has the functions of promoting blood circulation, removing blood stasis, dredging channels and relaxing collaterals. It is used for chest pain, stroke, coronary heart disease and angina pectoris caused by congestion. It is a compound preparation composed of Danshen and safflower. Salvia miltiorrhiza has the effects of promoting blood circulation, removing blood stasis, regulating qi and relieving pain. The water-soluble phenolic acids in danshen, such as danshensu, protocatechualdehyde, and salvianolic acid B, are the main active components of danshen. Safflower has the effect of promoting blood circulation and dredging collaterals, and the active ingredients are mainly concentrated in water-soluble safflower yellow, suc...

Claims

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Application Information

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IPC IPC(8): G01N21/35G01N21/359
Inventor 吴永江金叶吴增增刘雪松苏晓涛刘象银陆世海王臣臣王振华
Owner ZHEJIANG UNIV
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