Fluorescently-labeled hydroxyapatite hollow microsphere and preparation method thereof
A hydroxyapatite and fluorescent labeling technology, applied in the fields of biomedical materials and optical functional materials, can solve the problems of easy attenuation of fluorescence intensity, physiological toxicity, etc., and achieve the effect of avoiding environmental pollution and solving fluorescence attenuation.
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Embodiment 1
[0025] A. Eu(NO 3 ) 3 and a calcium hydroxide solution with a concentration of 0.01mol / L, the Eu(NO 3 ) 3 dissolved in a calcium-containing solution to obtain solution I;
[0026] B. Prepare a phosphoric acid solution with a concentration of 0.01mol / L;
[0027] C. According to the molar ratio of Eu ion, Ca ion and phosphate ion is 0.01: 0.99: 0.6, take the solution I obtained in step A and the phosphoric acid solution obtained in step B, and mix the obtained solution I and the phosphoric acid solution under 50w ultrasonic treatment, At the same time, alkali solution is added to adjust the pH value to 10 to form a suspension system II of nano-hydroxyapatite sol;
[0028] D. Place the suspension system II obtained in step C at 20°C for aging in an autoclave for 24 hours, then wash and dry to obtain the chemical composition formula Ca 0.99 Eu 0.01 (PO 4 ) 0.6 (OH) 0.2 Fluorescently labeled hydroxyapatite powder;
[0029] E. The fluorescently labeled hydroxyapatite...
Embodiment 2
[0033] A. According to the molar ratio of (Er ion + Ho ion) to Ca ion is 0.1︰0.9, take Er(NO 3 ) 3 、Ho(NO 3 ) 3 and a calcium nitrate solution with a concentration of 0.2mol / L, Er(NO 3 ) 3 、Ho(NO 3 ) 3 dissolved in calcium nitrate solution to obtain solution I;
[0034] B. The preparation concentration is the diammonium hydrogen phosphate solution of 0.133mol / L;
[0035] C. According to (Er ion+Ho ion), the molar ratio of Ca ion and phosphate ion is 0.1︰0.9︰0.6, get the solution I obtained in step A and the phosphate solution obtained in step B, and combine the solution I and the phosphate solution in Mix under 20w ultrasonic treatment, and add ammonia water to adjust the pH value to 10.5 at the same time, forming the suspension system II of nano-hydroxyapatite sol;
[0036] D. Place the suspension II obtained in step C in an ultrasonic field for 30 hours at 160°C, and then wash and dry to obtain the chemical composition formula Ca 0.9 Er0.05 Ho 0.05 (PO 4 ) 0....
Embodiment 3
[0041] A. According to the molar ratio of (Sm ion + Tm ion + Tb ion) to Ca ion is 0.09︰0.91, take Sm(NO 3 ) 3 , Tm(NO 3 ) 3 , Tb(NO 3 ) 3 and a calcium nitrate solution with a concentration of 3mol / L, the Sm(NO 3 ) 3 , Tm(NO 3 ) 3 , Tb(NO 3 ) 3 dissolved in calcium nitrate solution to obtain solution I;
[0042] B. Prepare a disodium hydrogen phosphate solution with a concentration of 3mol / L;
[0043] C. According to (Sm ion+Tm ion+Tb ion), the molar ratio of Ca ion and phosphate ion is 0.09︰0.91︰0.6, take the solution I obtained in step A and the disodium hydrogen phosphate solution obtained in step B, and mix the obtained solution I with phosphoric acid The disodium hydrogen solution was mixed under 80w ultrasonic treatment, and ammonia water was added to adjust the pH value to 11 at the same time to form a suspension system II of nano-hydroxyapatite sol;
[0044] D. Put the suspension system II obtained in step C at 80°C in a magnetic field to age for 36 hou...
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