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End-point fixing preparation method for multi-aldehyde alginic acid coating

A technology of polyaldehyde-based sodium alginate and sodium alginate, which can be applied to coatings, special packaging items, packaging item types, etc., can solve the problems of poor anticoagulant activity, poor biocompatibility, potential toxicity, etc., and achieve low cost. , mild reaction, low natural toxicity effect

Inactive Publication Date: 2013-09-04
TIANJIN CITY THIRD CENT HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to overcome the deficiencies of the prior art. In order to overcome the shortcomings of ordinary polymer materials such as poor biocompatibility, poor anticoagulant activity, and potential toxicity, a polyaldehyde-based Preparation method of sodium alginate coating

Method used

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  • End-point fixing preparation method for multi-aldehyde alginic acid coating
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  • End-point fixing preparation method for multi-aldehyde alginic acid coating

Examples

Experimental program
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Effect test

Embodiment 1

[0023] In the first step, 0.344 g of potassium permanganate was dissolved in 162 ml of deionized water, and 10 ml of 95 wt % concentrated sulfuric acid was slowly added to mix the concentrated sulfuric acid and potassium permanganate evenly.

[0024] In the second step, the polymer material PVC is added to the solution obtained in the first step, and the reaction is fully stirred for 10 minutes.

[0025] The third step is to oxidize the alginic acid according to the molar ratio of sodium periodate to sodium alginate unit of 1:10, so that the end of the alginic acid segment is exposed to aldehyde groups, ethylene glycol terminates the reaction, 96wt% ethanol aqueous solution is precipitated, and suction is filtered after the precipitation , dialyzed, and freeze-dried at -80°C to obtain polyaldehyde sodium alginate. The oxidation reaction was stirred and reacted for 24 hours in the dark.

[0026] In the fourth step, the polymer material pretreated in the second step is immersed...

Embodiment 2

[0030] In the first step, 0.328 g of potassium permanganate was dissolved in 144 ml of deionized water, and 20 ml of 95% concentrated sulfuric acid was slowly added to mix the concentrated sulfuric acid and potassium permanganate evenly.

[0031] In the second step, the polymer material is added to the solution obtained in the first step, and the mixture is stirred and fully reacted for 1 min.

[0032] The third step is to oxidize the alginic acid according to the molar ratio of sodium periodate and sodium alginate unit 3:10, so that the end of the alginic acid fragment is exposed to the aldehyde group, ethylene glycol terminates the reaction, 96% ethanol precipitation, suction filtration after precipitation, Dialyze and freeze-dry at -80°C to obtain polyaldehyde sodium alginate. The oxidation reaction was stirred and reacted for 40 hours in the dark.

[0033] In the fourth step, the polymer material pretreated in the second step is immersed in a 0.5% polyethyleneimine aqueou...

Embodiment 3

[0036] In the first step, 0.328 g of potassium permanganate was dissolved in 144 ml of deionized water, and 20 ml of 95% concentrated sulfuric acid was slowly added to mix the concentrated sulfuric acid and potassium permanganate evenly.

[0037] In the second step, the polymer material is added to the solution obtained in the first step, and stirred and fully reacted for 8 minutes.

[0038] The third step is to oxidize the alginic acid according to the molar ratio of sodium periodate and sodium alginate unit 1:10, so that the end of the alginic acid fragment is exposed to aldehyde groups, ethylene glycol terminates the reaction, 96% ethanol precipitates, and after the precipitation, suction filtration, Dialyze and freeze-dry at -80°C to obtain polyaldehyde sodium alginate. The oxidation reaction was stirred and reacted for 30 hours under the condition of avoiding light.

[0039] In the fourth step, the polymer material pretreated in the second step is immersed in a 0.05% pol...

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Abstract

The invention discloses an end-point fixing preparation method for a multi-aldehyde alginic acid coating. The method comprises the following steps: firstly, polymer material is soaked into sulfuric acid solution of potassium permanganate for acidizing treatment; then the material subjected to acidizing treatment is placed into polyethylene imine solution so as to obtain an amination decorated surface after reaction; periodic acid or sodium periodate is used for oxidation treatment to sodium alginate, aldehyde group is exposed at the tail end of the segment of alginic acid, and multi-aldehyde sodium alginate is obtained; the liquid reactant of the multi-aldehyde sodium alginate is prepared, the material on the amination decorated surface is placed into the liquid reactant, and the multi-aldehyde alginic acid coating is obtained through an end-point fixing method. The preparation method provided by the invention overcomes the defects of bad biocompatibility, poor anticoagulant activity, potential toxicity and the like in common polymer material.

Description

technical field [0001] The invention relates to the technical field of polymer material surface coatings, in particular to a preparation method for modifying polymer material surface coatings by utilizing polysaccharide molecular fragments. Background technique [0002] The application of biomedical materials faces two major problems: biocompatibility and blood compatibility. Coating technology improves the biocompatibility and anticoagulant activity of the surface of biomedical materials by pre-modifying the surface of the material. Heparin is a mucopolysaccharide with a molecular weight of 5000-40000. It is a mixture of negatively charged linear polysaccharides. The most important property of heparin is its anticoagulant properties. The anticoagulant activity of heparin comes from its ability to interact with various Coagulation inhibitors interact to achieve the purpose of anticoagulation by accelerating or increasing the anticoagulant activity of these inhibitors, but t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J7/14C08J7/12C08J7/04C08B37/04C08L23/06C08L27/06C08L23/12C08L67/00C08L83/04C08L77/00C08L69/00C08L27/18A61L33/08
Inventor 高文卿周秦段大为胡晓旻宁萌于美丽刘东李彤
Owner TIANJIN CITY THIRD CENT HOSPITAL
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