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Medicament for treating apoplexy and hemiplegia and preparation method

A hemiplegia and drug technology, which is applied in the direction of drug combination, medical formula, medical preparations containing active ingredients, etc., can solve the problems of slow drug dissolution, unsuitable release of active ingredients, and reduced curative effect, so as to improve bioavailability, The content of active ingredients in the drug is high, and the effect of improving the curative effect

Inactive Publication Date: 2012-08-01
JILIN TIANQIANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage is that the drug obtained by this process dissolves slowly in the body, and the active ingredients are not suitable for release, resulting in reduced curative effect

Method used

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  • Medicament for treating apoplexy and hemiplegia and preparation method
  • Medicament for treating apoplexy and hemiplegia and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0010] A medicine for treating stroke and hemiplegia and a preparation method thereof, comprising the following steps:

[0011] (1) Raw material: Musk 2g; Antelope horn 5g; Panax notoginseng 25g; Gastrodia elata 25g; Scorpion 10g; Hot) 25g; Astragalus 100g; Dannanxing 25g; Dilong 50g; Chishao 50g; Angelica 50g;

[0012] (2) The above twenty-two flavors, except musk, the remaining black snake and other twenty-one flavors are pulverized into a fine powder of 200 mesh with a superfine pulverizer, and the mixing time is 30 minutes; the musk is ground into fine powder, and mixed with the above fine powder for grinding, Mix evenly, add 20g of refined honey and water for every 100g of powder, mix evenly, press into pellets, and dry (drying temperature: 60°C) to get the product.

experiment example

[0014] Process selection orthogonal experiment results are:

[0015] Factor level table:

[0016]

[0017] Orthogonal experiment design table and results

[0018]

[0019] According to the test results, the best experimental conditions are selected as follows: the crushing particle size is 200 mesh, the mixing time is 30 minutes, and the drying temperature is 60°C.

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Abstract

The invention relates to a preparation method of a traditional Chinese medicine, in particular to a medicament for treating apoplexy and hemiplegia and a preparation method. The preparation method comprises the following steps of: pulverizing the rest twenty-one herbs such as black snake apart from muskiness with a super micro pulverizer into fine powder of 200 meshes and mixing for 30 minutes; and grinding the muskiness, mixing and grinding with the fine powder, uniformly mixing, utilizing 20 g of refined honey for every 100 g of powder and adding water, mixing uniformly and then pressing into pills; and drying to obtain the medicament. Compared with an original process product, a process product has the advantages that: the difference in the content of an active ingredient paeoniflorin (C23H28O11) in each pill is 0.3 mg, the difference in dissolution time limit is 15 minutes, the bioavailability can be improved by 60 percent, the effect is obvious after process innovation and optimization, and the curative effect of the product is greatly improved.

Description

technical field [0001] The invention relates to a preparation method of a traditional Chinese medicine, in particular to a medicine for treating apoplexy and hemiplegia and a preparation method thereof. Background technique [0002] In the prior art, Musk Antithrombotic Pills (Shuimi Pills) are recorded in the national drug standards of the State Drug Administration, drug standard number: 2001ZFB0081, and the drug-prescription for treating stroke, hemiplegia, slurred speech, and dizziness is: Musk 2g; Antelope horn 5g; Panax notoginseng 25g; Gastrodia elata 25g; Scorpion 10g; Black snake 50g; Safflower 50g; Rehmannia glutinosa 50g; 100g; Dannanxing 25g; Dilong 50g; Chishao 50g; Angelica 50g; Functions and indications: dredging collaterals and activating blood circulation, refreshing the brain and dissipating blood stasis. For stroke, hemiplegia, slurred speech, dizziness, etc. Usage and dosage: take orally, 1 bag each time, 3 times a day. Its preparation method is as fol...

Claims

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Application Information

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IPC IPC(8): A61K36/8988A61K9/20A61P9/10A61P25/02
Inventor 颜忠辉
Owner JILIN TIANQIANG PHARMA
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