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Medicine for treating gastric ulcer and duodenal ulcer and preparing method and application thereof

A duodenal ulcer and drug technology, which is applied in the field of medicine, can solve the problems of large irritation and single drug dosage form, and achieve the effect of convenient taking, convenient carrying, and remarkable curative effect

Active Publication Date: 2012-08-01
SHAANXI UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] So far, the existing medicines have not completely cured gastric and duodenal ulcers, and the dosage forms of related medicines are relatively simple, and western medicines are more irritating to the body

Method used

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  • Medicine for treating gastric ulcer and duodenal ulcer and preparing method and application thereof
  • Medicine for treating gastric ulcer and duodenal ulcer and preparing method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] The preparation of embodiment 1 pharmaceutical tablet of the present invention

[0034] a. Dandelion is decocted and extracted 3 times with 14 times the amount of water, each time for 1.5 hours, the extracts are combined, filtered, concentrated until the medicinal material ratio is 1:2, and ethanol is added to make the alcohol content of the medicinal liquid reach 50%. Let it stand for 24 hours, filter, recover ethanol until there is no alcohol smell, concentrate until the medicinal material: concentrated solution = 1:3 is the upper column liquid, pass through the treated AB-8 macroporous resin column, the ratio of medicinal material to resin is 1 : 1, flow rate 2BV / h, diameter-to-height ratio is about 1:10, room temperature, after the resin absorbs the liquid medicine, wash with 6BV purified water 2BV / h to remove impurities, and then elute with 50% ethanol 5BV, flow rate 2BV / h, collect the eluate, recover ethanol under reduced pressure, continue to concentrate under re...

Embodiment 2

[0038] The preparation of embodiment 2 pharmaceutical capsules of the present invention

[0039] a. Dandelion is decocted and extracted 3 times with 14 times the amount of water, each time for 1.5 hours, the extracts are combined, filtered, concentrated until the medicinal material ratio is 1:2, and ethanol is added to make the alcohol content of the medicinal liquid reach 50%. Let it stand for 24 hours, filter, recover ethanol until there is no alcohol smell, concentrate until the medicinal material: concentrated solution = 1:3 is the upper column liquid, pass through the treated AB-8 macroporous resin column, the ratio of medicinal material to resin is 1 : 1, flow rate 2BV / h, diameter-to-height ratio is about 1:10, room temperature, after the resin absorbs the liquid medicine, wash with 6BV purified water 2BV / h to remove impurities, and then elute with 50% ethanol 5BV, flow rate 2BV / h, collect the eluate, recover ethanol under reduced pressure, continue to concentrate under ...

Embodiment 3

[0043] The quality control method of embodiment 3 medicines of the present invention

[0044] 1. Characters Observation and description of the medicine of the present invention prepared according to Example 1. This product described in quality control is the tablet of embodiment 1, is light brown tablet, slightly glossy, gas is fragrant, bitter in the mouth.

[0045] 2. Identification of this product (1) Take 10 tablets of this product, grind finely, weigh 3.0g, add 30mL of ethanol, ultrasonicate for 10 minutes, filter, and use it as the test solution. Another caffeic acid reference substance was weighed, and ethanol was added to make a solution containing 0.5mg per 1mL as the reference substance solution. According to the test of thin-layer chromatography (Appendix VI B of "Chinese Pharmacopoeia" 2005 edition), draw 5-10 μL of each of the above two solutions, respectively spot on the same silica gel G thin-layer plate, and mix with butyl acetate-formic acid-water ( 7:2.5:2....

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Abstract

The invention discloses a medicine for treating gastric ulcer and duodenal ulcer, which uses raw medicinal materials comprising dandelion, corydalis tuber and sea buckthorn oil or water extractive or organic solvent extractive as active ingredients, and medicinally acceptable accessories are added to prepare the medicine. The invention further provides a preparing method and an application of the medicine. The medicine prescription uses the commonly-used dandelion as the minister so as to treat gastric ulcer and duodenal ulcer, is remarkable in curative effect, can treat both principal and secondary aspects of disease, achieves the effects of clearing heat and harmonizing stomach, relieving hyperacidity and relieving pain and tonifying spleen and is in accordance with the characteristics of traditional Chinese medicine prescriptions.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a medicine for treating gastric and duodenal ulcers, a preparation method and application thereof. Background technique [0002] Gastric and duodenal ulcers are peptic ulcers and are common diseases worldwide. It is estimated that about 10% of the population will suffer from the disease in their lifetime. Domestic data show that its incidence is on the rise. The disease can occur at any age. Duodenal ulcers are more common in young adults, and gastric ulcers are more common in middle-aged and elderly people; the peak incidence of the former is 10 years earlier than that of the latter. The ratio of male to female incidence is 4.4 to 6.8:1 for duodenal ulcer and 3.6 to 4.7:1 for gastric ulcer. [0003] Traditional Chinese medicine attributes this disease to the categories of "epigastric pain", "fullness", "noisy", "abdominal distension", and "belching". Traditiona...

Claims

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Application Information

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IPC IPC(8): A61K36/66A61P1/04
Inventor 王昌利孙静史亚军张明
Owner SHAANXI UNIV OF CHINESE MEDICINE
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