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CdTe quantum dot-containing nano-artesunate capsule and its preparation method

A technology of artesunate and quantum dots, which is applied in the direction of medical preparations containing active ingredients, capsule delivery, microcapsules, etc., can solve the problems of fast metabolism, inconvenient clinical application, and low bioavailability, and achieve simple operation Effect

Inactive Publication Date: 2013-07-17
SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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  • Abstract
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Problems solved by technology

Artesunate is a derivative of the sesquiterpene lactone compound artemisinin. It is easily soluble in ethanol but almost insoluble in water. Its low bioavailability and fast metabolism bring a lot of inconvenience to clinical application.

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  • CdTe quantum dot-containing nano-artesunate capsule and its preparation method
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  • CdTe quantum dot-containing nano-artesunate capsule and its preparation method

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Embodiment Construction

[0025] Quantum dots are semiconductor crystals with a nanometer size. Due to the very small particle size, most of the atoms are located on the surface of the quantum dots. The increase in the number of surface atoms leads to insufficient coordination of surface atoms, and an increase in unsaturated bonds and dangling bonds. The surface atoms are highly active, extremely unstable, and easily combined with other atoms. In order to improve its stability and increase compatibility with artesunate, the applicant added L-cysteine ​​when synthesizing CdTe quantum dots to obtain cysteine-adsorbed CdTe quantum dots (see figure 1 ), with a particle size between 2.5 and 5.0nm, water-soluble CdTe quantum dots with strong fluorescence (such as figure 2 ).

[0026] The invention adopts the nascent microcrystal method, utilizes the self-organization method to realize three-layer nano packing, and prepares the nano artesunate capsule containing quantum dots. refer to image 3 , the speci...

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Abstract

The invention relates to a CdTe quantum dot-containing nano-artesunate capsule and its preparation method. The capsule is a nano-capsule taking the quantum dot as the core and cysteine as the transition layer, having artesunate loaded around, adopting gelatin as the wall material, and having three-layer packaging as well as a four-layer structure. Being in an ellipsoidal shape, the capsule has a capsule diameter of 180-220nm, and has observable fluorescence emission. The preparation method specifically comprises: first preparing a gelatin solution, adding a CdTe quantum dot solution into the 2% gelatin solution for adsorbing cysteine, conducting 10-fold dilution with ultrapure water, adding an artesunate anhydrous ethanol solution dropwisely, and adding an anhydrous sodium sulfate aqueoussolution and a sodium hydroxide solution, adjusting the pH, then adding 10 microliters of a formaldehyde solution, and carrying out dialysis as well as freeze drying, thus obtaining a CdTe quantum dot-containing nano-artesunate capsule product. The preparation method of the invention combines a drug and a fluorescent marker, embeds them jointly inside the nano-capsule, and is simple to operate. The prepared capsule can well maintain the fluorescence characteristics, and can be applied in real-time monitoring of the laws of transmission and distribution as well as capsule breaking and release of a nano-drug in vivo.

Description

technical field [0001] The invention relates to a nano artesunate capsule containing CdTe quantum dots and a preparation method thereof. Background technique [0002] Nanocapsules, as a new type of drug delivery system, have attracted widespread attention. Embedding fluorescent substances and drug molecules inside nanocapsules, combined with optical in vivo imaging technology, may become a real-time monitoring method for the transport and distribution of nanocapsules in vivo and the release of capsules. effective tool for behavior. At present, optical in vivo imaging technology is mainly divided into two methods: bioluminescence imaging and fluorescence imaging. In the way of fluorescence imaging, organic dyes are fluorescent markers in the traditional sense. Due to their lack of long-term fluorescence stability, the application of these fluorescent substances is limited. Therefore, it is inevitable to find a new fluorescent material. [0003] In recent years, quantum dot...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/50A61K31/357A61K47/02A61K47/42A61P33/06
CPCY02A50/30
Inventor 洪宗国赵丹
Owner SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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