Three-dimensional opto-acoustic imaging system based on acoustic lens and sensor array and method

Abstract

The invention relates to a three-dimensional opto-acoustic imaging system based on an acoustic leans and a sensor array and a method. The system is a cube experimental table and mainly comprises a laser device, a beam expander, the phonon crystal lens, the opto-acoustic sensor array, a data bus, a ground glass container, a data acquisition module and a computer for image processing, center points of four side surfaces of the cube ground glass container are irradiated by laser, so that a sample is uniformly irradiated by the laser via dispersion of ground glass, and is uniformly heated and expanded, acoustic signals generated by expansion of the sample focus to form a beam, the opto-acoustic sensor array, the data acquisition module and the computer for image processing acquire and record opto-acoustic three-dimensional imaging data in real time, and a three-dimensional light absorption distribution image of the detected sample can be directly seen from a display via image processing. The three-dimensional opto-acoustic imaging system has the advantages of complete functions, stable performance, low cost and the like, and can be widely applied to the fields of biology, medical science, material analysis and the like.

Description

technical field [0001] The invention belongs to the technical field of photoacoustic imaging, in particular to a three-dimensional photoacoustic imaging method and device based on an acoustic lens and a sensor array. Background technique [0002] Photoacoustic imaging technology is a non-destructive medical imaging method developed in recent years. It combines the high contrast characteristics of pure optical imaging and the high penetration depth characteristics of pure ultrasound imaging to provide high-resolution and high-contrast tissue imaging. Photoacoustic imaging technology is a new imaging technology using "light excitation-ultrasonic imaging". Photoacoustic imaging technology is a detection technology with strong adaptability and high sensitivity, especially suitable for non-destructive detection of strong scattering and non-transparent samples, and is widely used in biology, medicine, material analysis and other fields. [0003] At present, photoacoustic imaging ...

AI Technical Summary

Problems solved by technology

Wang L.V. developed the Radon inversion algorithm into a high-resolution photoacoustic imaging method. Both of these imaging methods avoid the limitation of the acoustic diffraction effect, so high-resolution imaging can be achieved, but due to the need to scan the imaging object and data averaging processing, etc., it takes a long time and may cause reconstruction artifacts

[0004] There have been many reports on photoacoustic imaging and in vivo functional imaging of simulated tissues, but the experimental equipment is complex, the data acquisition time is long, and the imaging algorithm is complex, the calculation is large, and the time to obtain a complete reconstructed image is often It takes several minutes to tens of minutes, which cannot meet the requirements of actual clinical application

At the same time, due to the mechanical scanning of hundreds of angles and the long-term data acquisition process, unstable factors such as mechanical vibration and random parameter drift caused by long-term operation of the instrument will inevitably bring random errors to the research results, thus seriously affecting the quality of imaging. and the reliability and stability of the research results

[0005] There are still some deficiencies in the existing photoacoustic imaging system. The general light source uses a pulsed laser, which is relatively bulky and expensive. In addition, the image effect is not up to the level of other imaging technologies, especially the imaging of deep tissues is affected by the absorption of tissues. more serious

Moreover, most of the existing photoacoustic imaging systems use hydrophones to realize two-dimensional imaging, and few use arrays to realize three-dimensional high-resolution photoacoustic imaging systems.

In addition, existing photoacoustic imaging systems rarely take into account the irregularities of samples

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