Natural pullulan polysaccharide hydrogel wound dressing and preparation method thereof

Abstract

The invention discloses a natural pullulan polysaccharide hydrogel wound dressing, which is prepared by undergoing a cross-linking reaction on a carboxy methylation pullulan polysaccharide and a hydrazine or diamine, wherein the crosslinking degree of carboxyl of the carboxy methylation pullulan polysaccharide and the hydrazine or the amino of the diamine is 30-90 percent. A preparation method of the wound dressing comprises the following steps of: performing carboxy methylation on the natural pullulan polysaccharide, preparing the carboxy methylation pullulan polysaccharide into a solution of which the concentration is 0.1-1.0g / ml by using deionized water, adding the hydrazine or diamine into the aqueous solution of the carboxy methylation pullulan polysaccharide with stirring at normal temperature and under normal pressure, adding an aqueous solution of 1-(3-dimethylamino propyl)-3-carbodiimide hydrochloride of which the concentration is 0.5-1.0g / ml after uniformly stirring, and uniformly stirring; and standing the obtained solution at normal temperature, crosslinking for at least 10 minutes, soaking into deionized water for at least 6 days after crosslinking, removing impurities, and drying in vacuum to obtain the natural pullulan polysaccharide hydrogel wound dressing.

Description

technical field [0001] The invention belongs to the field of macromolecule biomedical materials, and in particular relates to a natural pullulan hydrogel wound dressing and a preparation method thereof. Background technique [0002] Studies have shown that a humid environment is conducive to wound healing, and an appropriate water vapor transmission rate can prevent excessive dehydration of the wound. Lamke et al. (Lamke LO, Nilsson GE, Reithner HL.Burns 1977; 3:159-165.) reported that the water vapor transmission rates of normal skin, granulated wounds, and first-degree scald wounds were 204±12g / m 2 / day, 5138±202g / m 2 / day, 279±26g / m 2 / day. Relevant reports (Wu P, Fisher AC, Queen D, Gaylor JD.Biomaterials1995; 16:171-175.) show that there is 2000g / m 2 / day~2500g / m 2 The wound dressing with / day water vapor transmission rate can provide a moist growth environment for the wound. The water vapor transmission rates of Vigilon1 wound dressing and Geliperm1 wound dressin...

AI Technical Summary

Problems solved by technology

Such a high water vapor transmission rate will lead to complete dehydration of the wound, making the dressing stick to the wound surface and causing secondary trauma when changing

[0003] There are a large number of literature reports, the commonly used polymers synthesized by electron beam radiation cross-linking grafting technology include polyvinylpyrrolidone, polyvinyl alcohol, polyethylene oxide and polyethylene oxide, and the hydrogel wound dressings prepared by them are Although the mechanical properties are good, the swelling performance is poor, and the application in rapid hemostasis and absorption of exudate during skin healing is limited, and the synthesis process is complicated and costly

There are a large number of literature reports that although the hydrogel prepared by cross-linking natural polysaccharides has good biocompatibility, it often has poor mechanical properties and cannot meet the needs of dressings.

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