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A kind of compound dextromethorphan hydrobromide syrup and preparation method thereof

A technology of dextromethorphan hydrobromide and syrup is applied in the directions of pharmaceutical formulations, medical preparations without active ingredients, medical preparations containing active ingredients, etc., and can solve the problem of low curative effect, compound dextromethorphan hydrobromide syrup Instability and low safety

Active Publication Date: 2018-11-02
湖北凤凰白云山药业有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The object of the present invention is to: provide a kind of compound dextromethorphan hydrobromide syrup and preparation method thereof, the compound dextromethorphan hydrobromide syrup of the present invention improves the safety of medication, is especially suitable for children; Covers the bitter taste, And reduce the application of fragrance; Improve the stability of syrup especially the stability of solution color and color; Improve the curative effect that treats cold and bronchitis to cause cough at the same time, solve compound dextromethorphan hydrobromide syrup for a long time. Stable, low curative effect and low safety issues ensure its quality control and stability enhancement, simple process, easy absorption, definite curative effect, safety, and better meet clinical needs

Method used

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  • A kind of compound dextromethorphan hydrobromide syrup and preparation method thereof
  • A kind of compound dextromethorphan hydrobromide syrup and preparation method thereof
  • A kind of compound dextromethorphan hydrobromide syrup and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0049] Weigh 500g of sucrose, add 500g of purified water, boil to dissolve, add 1g of caramel coloring to boil, filter, let cool to 40°C; weigh 1g of dextromethorphan hydrobromide and 10g of guaiacol glyceryl ether, and use Stir 10g of ethanol to dissolve, add water at 70°C and stir thoroughly, after cooling, add 10g of Bacillus natto extract to completely dissolve until clear, then filter, add the filtrate and 50g of 1,2-propanediol to the above syrup, and make the liquid The relative density at 25°C is 1.08; heat the syrup to 50°C, add an appropriate amount of warm water at 50°C and 1g of citric acid, stir well, and filter the liquid after cooling down to below 50°C, the filtrate is cough-relieving Phlegm syrup;

[0050] Among them, the preparation of Bacillus natto extract: After Bacillus natto is activated, one ring of bacteria is picked from the slope and inserted into the beef extract peptone culture solution, cultivated at 25°C for 10 hours, and the bacterial suspension...

Embodiment 2

[0057] Weigh 800g of sucrose, add 800g of purified water, boil to dissolve, add 4.5g of caramel pigment, boil, filter, let cool to 60°C; weigh 6g of dextromethorphan hydrobromide, 30g of guaiacol glyceryl ether, Stir and dissolve with 20ml of ethanol, add water at 90°C and stir thoroughly, after cooling, add 50g of Bacillus natto extract to completely dissolve until clear and filter, add the filtrate and 150g of 1,2-propanediol to the above syrup, make The relative density of the liquid medicine at 25°C is 1.25; heat the syrup to 50°C, add an appropriate amount of warm water at 50°C, 5g of citric acid and an appropriate amount of essence, stir well, and filter the liquid after the temperature of the liquid medicine is cooled to below 50°C. The filtrate is an antitussive and expectorant syrup;

[0058] Among them, the preparation of Bacillus natto extract: After Bacillus natto is activated, one ring of bacteria is picked from the slope and inserted into the beef extract peptone...

Embodiment 3

[0065] Weigh 600g of sucrose, add 600g of purified water, boil to dissolve, add 2g of caramel pigment to boil, filter, let cool to 50°C; weigh 3g of dextromethorphan hydrobromide and 20g of guaiacol glyceryl ether, and use Stir and dissolve 10g of ethanol, add 80°C water and stir thoroughly, after cooling, add 25g of Bacillus natto extract to completely dissolve until clear and then filter, add the filtrate and 100g of 1,2-propanediol to the above syrup, and make the medicine The relative density of the solution at 25°C is 1.48; heat the syrup to 50°C, add an appropriate amount of warm water at 50°C and 8g of citric acid, stir well, and filter the liquid after the temperature of the liquid is cooled to below 50°C, and the filtrate is antitussive expectorant syrup;

[0066] Among them, the preparation of Bacillus natto extract: After Bacillus natto is activated, one ring of bacteria is picked from the inclined surface and inserted into the beef extract peptone culture solution,...

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Abstract

The invention provides a compound dextromethorphan hydrobromide syrup and a preparation method for the same. The compound dextromethorphan hydrobromide syrup is used for eliminating phlegm in cough, and comprises dextromethorphan hydrobromide, guaifenesin and a bacillus natto extract. The syrup improves the safety of medication and is especially suitable for children, reduces bitter taste and the consumption of a flavouring agent, improves the stability, especially the colour of solution and the stability of the colour, and improves the curative effect on the cough caused by cold and bronchitis simultaneously.

Description

Technical field: [0001] The invention relates to the technical field of a medicine for antitussive and expectorant and the preparation process of the syrup thereof, in particular to compound dextromethorphan hydrobromide syrup and a preparation method thereof. Background technique: [0002] A cold is an upper respiratory tract infection caused by a variety of viruses, commonly known as "cold", and is a common respiratory disease that can occur in all seasons. It has a wide range of prevalence and infectivity. If it is not controlled in time, it can cause complications such as viral pneumonia and myocarditis, which will seriously endanger human health. Cold is clinically divided into common cold and influenza. Bronchitis is a common disease among middle-aged and elderly people in winter. Mostly because acute bronchitis is not cured in time and changes. According to statistics, the incidence rate of middle-aged and elderly people over the age of 50 in my country is about 15...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K35/74A61K47/46A61P11/14A61P11/10A61K31/485A61K31/09A61K35/742
Inventor 程雪翔
Owner 湖北凤凰白云山药业有限公司
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