Application and preparation method of sibutramine in preparation of information therapeutic drug and novel drug prepared by preparation method

Abstract

The invention discloses application and a preparation method of sibutramine in preparation of an information therapeutic drug and a novel drug prepared by the preparation method. The information therapeutic drug is characterized in that the drug does not contact a human body directly during treatment, any substance ingredient of the drug can not be consumed, only drug information is utilized for physical treatment, but the chemical treatment effect can be achieved, a treatment window is enlarged by more than 1000 times, and the side effects of chemical treatment are avoided. After sibutramine is used as the information therapeutic drug, the contents of active ingredients are not changed, and sibutramine can also be used as a conventional preparation in the chemical treatment for secondary effective use.

Description

technical field [0001] The invention relates to the field of medicines, in particular to a novel medicine of sibutramine. Background technique [0002] Compound Sibutramine hydrochloride, chemical name: N-{1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutyl}-N,N'-dimethylamine- Hydrated hydrochloride, chemical formula C 17 h 26 CLH·HCl·H 2 O, molecular weight 334.33. The properties are white crystalline powder, odorless and tasteless. Instantly soluble in water and alcohol. Sibutramine is a weight-loss drug, clinically used to treat obesity and the like. The pharmaceutical preparations of sibutramine include tablets, capsules and the like. The known sibutramine drugs are all used as chemotherapeutic drugs, which allow the compound sibutramine molecules to enter the human body (through oral absorption into the blood), distribute to various tissues, and produce sibutramine molecules through chemical reactions in the human body. pharmacological effects. In the prior art, si...

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Problems solved by technology

In the prior art, sibutramine is used as a chemotherapeutic drug, and there are defects that cannot be overcome so far. The first is the toxic and side effects on the human body, and its annoying adverse reactions include increased heart rate, arrhythmia, increased blood pressure, and insomnia. , headache, easy to wake up, irritability, dry mouth, fear of eating, constipation and interstitial nephritis, peripheral edema, arthritis, etc.; second, the treatment window is small, and due to the existence of toxic and side effects on the human body, the effective dose that can be used is very small. Small, which limits the therapeutic effect. The maximum dose of oral administration is 15mg once, 30mg a day, and poisoning can be caused if the maximum dose is exceeded; the third is that there is only one use of chemotherapy drugs, and the drugs are metabolized and decomposed or excreted when they enter the human body. secondary application

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