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Radix acanthopanacis senticosl composition, preparation containing composition and detection method of preparation

A detection method and composition technology, applied in the field of pharmaceutical inventions, can solve the problems of increased detection workload, difficulty in providing detection data by the production department, long time, etc., and achieve the effect of excellent effect, less impurities and stable quality

Active Publication Date: 2012-07-18
HARBIN ZHENBAO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0021] The existing detection method adopts ordinary high-performance liquid chromatography, and the detection time is generally 50 minutes, which is relatively long. When there are many production batches on the day, the detection workload will increase significantly, and it is difficult to provide detection data to the production department in time

Method used

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  • Radix acanthopanacis senticosl composition, preparation containing composition and detection method of preparation
  • Radix acanthopanacis senticosl composition, preparation containing composition and detection method of preparation
  • Radix acanthopanacis senticosl composition, preparation containing composition and detection method of preparation

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0091] Embodiment 1: Acanthopanax composition

[0092] 1. Extraction method:

[0093] 1) Take Acanthopanax 2000g, crush it, add purified water to decoct twice, add 6 times the amount of purified water for the first time, soak for 30 minutes, boil for 3 hours, add 6 times the amount of purified water for the second time, boil for 2 hours, filter Pass;

[0094] 2) When the temperature of the filtrate drops to 50°C, adjust the pH value to 11.0 with 20% milk of lime, and fully stir; then adjust the pH value to 5.5 with 20% sulfuric acid, fully stir, let stand for 4 hours, filter the supernatant, Concentrate into a concentrated paste with a relative density of 1.14 measured at 80°C;

[0095] 3) When the temperature of the concentrated paste drops to 50°C, slowly add ethanol to make the alcohol content reach 85%, stir well, let it stand for 12 hours, filter, recover the ethanol from the filtrate until it has no alcohol smell and concentrate until it is measured at 80°C The densit...

Embodiment 2

[0121] Embodiment 2: Acanthopanax composition

[0122] 1. Extraction method:

[0123] 1) Take Acanthopanax 2000g, crush it, add purified water to decoct twice, add 7 times the amount of purified water for the first time, soak for 30 minutes, boil for 3 hours, add 5 times the amount of purified water for the second time, boil for 2 hours, filter Pass;

[0124] 2) When the temperature of the filtrate drops to 30°C, adjust the pH value to 12.0 with 20% milk of lime, and fully stir; then adjust the pH value to 5.0 with 20% sulfuric acid, fully stir, let stand for 6 hours, filter the supernatant, Concentrate into a concentrated paste with a relative density of 1.10 measured at 80°C;

[0125] 3) When the temperature of the concentrated ointment drops to 30°C, slowly add ethanol to make the alcohol content reach 83%, stir well, let it stand for 16 hours, filter, recover the ethanol from the filtrate until it has no alcohol smell and concentrate until it is measured at 80°C Density...

Embodiment 3

[0129] Embodiment 3: Acanthopanax composition

[0130] 1. Extraction method:

[0131] 1) Take 2000g Acanthopanax, crush it, add purified water to decoct 3 times, add 5 times the amount of purified water for the first time, soak for 30 minutes, boil for 2 hours, add 5 times the amount of purified water for the second time and boil for 2 hours, Add 4 times the amount of purified water three times, boil for 2 hours, and filter;

[0132] 2) When the temperature of the filtrate drops to 40°C, adjust the pH value to 10.0 with 20% milk of lime, and fully stir; then adjust the pH value to 6.0 with 20% sulfuric acid, fully stir, let stand for 8 hours, filter the supernatant, Concentrate into a concentrated paste with a relative density of 1.20 measured at 80°C;

[0133] 3) When the temperature of the concentrated paste drops to 40°C, slowly add ethanol to make the alcohol content reach 84%, stir well, let it stand for 14 hours, filter, recover the ethanol from the filtrate until it h...

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Abstract

The invention relates to a radix acanthopanacis senticosl composition, a preparation containing the composition and a content detection method of the preparation. The composition per gram contains 50-120mg of total flavones, 12.5-30mg of syringin and 4-15mg of eleutheroside E. The composition and preparation provided by the invention have effects on lowering blood sugar level, lowering blood lipid and treating male sterility and have better effects than the prior art.

Description

technical field [0001] The invention relates to the field of medical inventions, in particular to an Acanthopanax acanthopanax composition, its preparation and its detection method. Background technique [0002] Radix Acanthopanacis Senticosl is the root, rhizome and stem of Araliaceae, mainly distributed in Northeast China, Russian Far East, Hokkaido, Japan and North Korea. It was first seen in the "Shen Nong's Materia Medica" in the Eastern Han Dynasty. "Compendium of Materia Medica" records that Acanthopanax can "replenish strength and essence, improve eyesight and lower qi", can "replenish five labors and seven injuries, take long-term use to lighten body and endure old age", and has the effects of nourishing qi, strengthening spleen, tonifying kidney and calming nerves. [0003] The main functional components of Acanthopanax senticosus are phenolic glycosides and some aglycone components, mainly including total glycosides and total flavonoids of Acanthopanax senticosus...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/254A61P5/00A61P9/00A61P9/10A61P7/02A61P3/06A61P25/00A61P15/00A61P15/08G01N30/02G01N21/31A61K31/7034
Inventor 方同华
Owner HARBIN ZHENBAO PHARMA
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