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Elecampane soft capsule with auxiliary protection function for gastric mucosa damage and preparation method thereof

A technology for gastric mucosal injury and protection functions, which is applied in the field of medicine and achieves the effects of easy portability, high content of active ingredients and high bioavailability

Inactive Publication Date: 2012-07-04
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0019] To sum up, there has not yet been a CO 2 A patent report on the supercritical extraction technology to extract the active ingredients from the woody medicinal materials that can assist in the protection of gastric mucosal damage, and dissolve them in edible oil to make soft capsules

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Take 1 kg of the coarse powder of the woody medicinal material, pass CO 2 For supercritical extraction, the extraction pressure is set to 24MPa, the extraction temperature is 45°C, the extraction time is 1.5 hours, CO 2 The volume flow rate is 8L / h, and the pressure is 7MPa, the temperature is 35-55 ℃, and the analysis is carried out to extract the cosmosan lactone and dehydrocosmosan lactone from the coriander, which is a brown-red or brown-yellow translucent oil , the extraction rate was 17.69%. Finally, the extracted total lactones of xanthophyll are dissolved in olive oil to make soft capsules.

Embodiment 2

[0049] Take 1 kg of the coarse powder of the woody medicinal material, pass CO 2 For supercritical extraction, the extraction pressure is set to 26MPa, the extraction temperature is 50°C, the extraction time is 1.5 hours, CO 2 The volume flow rate is 10L / h, the pressure is 7MPa, the temperature is 35-55 ℃, and the analysis is carried out to extract the cosmolide and dehydrocosmolide from the coriander, which is a brown-red or brown-yellow translucent oil , the extraction rate was 18.09%. Finally, the extracted total lactones of xanthophyll are dissolved in olive oil to make soft capsules.

Embodiment 3

[0051] Take 1 kg of the coarse powder of the woody medicinal material, pass CO 2 For supercritical extraction, the extraction pressure is set to 28MPa, the extraction temperature is 55°C, the extraction time is 1.5 hours, CO 2 The volume flow rate is 12L / h, the pressure is 7MPa, and the temperature is 35-55°C, and the analysis is carried out to extract the cosmolide and dehydrocosmolide from the coriander, which is a brown-red or brown-yellow translucent oil , the extraction rate was 18.07%. Finally, the extracted total lactones of xanthophyll are dissolved in olive oil to make soft capsules.

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Abstract

The invention provides an elecampane soft capsule with an auxiliary protection function for gastric mucosa damage and a preparation method thereof. The invention particularly relates to the preparation method characterized in that the CO2 supercritical extraction technology is adopted in the traditional Chinese medicine elecampane to extract effective ingredients with the auxiliary protection function for the gastric mucosa damage, and extract is dissolved in edible oil to obtain a soft capsule health-care medicine. The technology is easy to operate and is suitable for industrial production. The elecampane soft capsule developed with the method has the advantages of favorable stability and good curative effect and brings good news for patients with the gastric mucosa damage, and the quality of the elecampane soft capsule conforms to the standard.

Description

technical field [0001] The present invention relates to the technical field of medicine, specifically through CO 2 The supercritical extraction technology extracts the active ingredients that can help protect the gastric mucosa from the woody medicinal materials, and mixes them with edible oil to make soft capsules. Background technique [0002] With the popularization of medical knowledge and the enhancement of people's awareness of health care, people have realized that the occurrence of some diseases is closely related to lifestyle and eating habits. Emphasis on prevention, began to look for nutritional health food and Chinese herbal medicine for preventive therapy. Therefore, people pay more and more attention to health care medicines. The difference between health care medicines and medicines is that health care medicines focus on prevention, while medicines focus on treatment and have side effects. Health care medicines play the role of nutrition, health care, and dis...

Claims

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Application Information

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IPC IPC(8): A61K36/285A61K9/48G01N30/90G01N30/36A61P1/04A61K125/00
Inventor 金向群王诗惠张金萍刘京硕李金卓邵岩
Owner JILIN UNIV
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