Plant officinal hollow capsule and preparation method thereof
A hollow capsule and medicinal technology, applied in the directions of capsule delivery, pharmaceutical formulations, and inactive medical preparations, etc., can solve the problems of unqualified gelatin capsule dissolution, slow disintegration, hidden dangers, etc., and achieve broad market prospects. and practical value, improved disintegration performance, low cost effect
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Embodiment 1
[0028] First prepare the partial enzymatic hydrolyzate of kudzu powder, weigh 160 grams of kudzu powder, put it in a 1000 ml conical flask, add 800 g of deionized water in batches, stir while adding water, adjust the pH to 5.5 with hydrochloric acid, raise the temperature to 95 °C, and keep it warm for 10 Minutes, the inside of the triangular flask is a uniform viscous paste, transfer the triangular flask to a portable sterilizer, and heat it at 121°C for 30 minutes to completely gelatinize.
[0029] The gelatinized kudzu root powder is cooled to 60°C, and isoamylase is added with an enzyme dosage of 8000 enzyme units. The enzymolysis reaction is incubated at 60°C in a water bath for 180 minutes, and immediately transferred to boiling water for 20 minutes to terminate the enzyme reaction.
[0030] The above reaction solution was centrifuged at 8000rpm on a TG16-WS desktop centrifuge for 17 minutes, the lower part of the precipitate was removed, and the upper part of the centrif...
Embodiment 2
[0034]Add 5 grams of pullulan and 0.5 grams of glycerin to 100 ml of the upper centrifugation liquid (containing about 20 grams of solids) of the upper part of the arrowroot enzymolysis solution made according to Example 1; add 0.3 grams of gellan gum to another beaker, add 50 ml to remove Boil deionized water until completely dissolved, then add 0.18 grams of potassium chloride, mix with arrowroot enzymatic hydrolyzate and pullulan immediately while hot, then add 0.025 grams of sodium dodecylsulfonate, all the above mixtures are emulsified and sheared with FA25 Machine 8000 revolutions per minute to mix evenly, keep warm in a 200ml beaker above 70°C for 4 hours to debubble, cool down the mixture after degassing to 53°C~58°C, dip the hollow capsule manual mold with glue , the mold dipped in glue is placed in an electric oven at 30°C~40°C to air dry, the wall thickness of the capsule after demoulding is 0.08mm~0.12mm, and the hollow capsule inspection: good and standard size, hi...
Embodiment 3
[0036] Add 10 grams of carboxymethyl cellulose and 0.6 grams of glycerin to 100 ml of the upper centrifugation liquid of the partial enzymolysis solution of arrowroot powder made according to Example 1 (containing about 20 grams of solid matter); add 0.35 grams of gellan gum to another beaker, and add 70 ml Boil deionized water until completely dissolved, then add 0.20 grams of potassium chloride, immediately mix with arrowroot hydrolyzate and carboxymethyl cellulose while hot, then add 0.03 grams of sodium dodecylsulfonate, all the above mixtures are emulsified with FA25 The shearing machine rotates at 8000 rpm and mixes evenly. In a 200ml beaker, keep warm at 70°C for 4 hours. After degassing, the mixture cools down to 53°C~58°C. Dip the hollow capsule into a manual mold and place the mold dipped in electric heating. Air-dry in an oven at 30°C~40°C. The wall thickness of the capsule after demolding is 0.08mm~0.12mm. Empty capsule testing: as the preheating temperature for pin...
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