Eureka AIR delivers breakthrough ideas for toughest innovation challenges, trusted by R&D personnel around the world.

High concentration pidotimod oral liquid

A liquid preparation, the technology of pidotimod, which is applied in the pharmaceutical field, can solve the problems of unstable product quality and difficulty in long-term stable storage, and achieve the effects of high stability, stable storage, and good quality stability

Active Publication Date: 2013-07-10
SUZHOU SIXTH PHARMA PLANT OF JIANGSU WUZHONG PHARMA GROUP
View PDF7 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The technical problem to be solved by the present invention is the problem that the pidotimod oral liquid preparation in the prior art does not add any pH regulator, resulting in unstable product quality and difficult long-term stable storage. The reasonable ratio between the parts, so that the quality is stable, and the pidotimod oral liquid preparation is easy to store stably

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • High concentration pidotimod oral liquid
  • High concentration pidotimod oral liquid
  • High concentration pidotimod oral liquid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031]

[0032] Dissolve 200 g of glycerin and 304 g of tris in 600 ml of purified water as solution 1; then add 80 g of pidotimod into 200 ml of purified water and stir to form a suspension.

[0033] Under stirring conditions, slowly add solution 1 to the suspension solution, stir well to dissolve pidotimod, then add 50 g of sucralose and 80 g of sorbitol, and stir; use the remaining amount of tris to adjust The pH value of the solution is 4.5-6.5; add 2 g of food essence, add purified water until the total amount of the preparation is 1000 ml, and fill it to obtain a 10 ml, 0.8 g pidotimod oral liquid preparation.

Embodiment 2

[0035]

[0036] Dissolve 2 g of edetate disodium, 200 g of glycerin, and 375 g of tris in 600 ml of purified water as solution 1; then add 80 g of pidotimod into 200 ml of purified water, and stir to form a suspension.

[0037] Under stirring conditions, slowly add solution 1 to the suspension solution, stir well to dissolve pidotimod, then add stevioside 100g and aspartame 30g, stir; use 10% sodium hydroxide aqueous solution 20ml to adjust the solution pH value to 4.8-5.6; add 2g of food essence, add purified water until the total amount of the preparation is 1000ml, and fill it to obtain a 10ml, 0.8g pidotimod oral liquid preparation.

Embodiment 3

[0039]

[0040] Dissolve 150 g of calcium sodium edetate and 298 g of tris in 600 ml of purified water as solution 1; then add 50 g of pidotimod into 200 ml of purified water and stir to form a suspension.

[0041]Under stirring conditions, slowly add solution 1 to the suspension solution, stir fully to dissolve pidotimod, then add 40 g of acesulfame potassium and 60 g of xylose, and stir; adjust the pH of the solution with 20 ml of 10% aqueous sodium hydroxide solution value to 4.8-5.6; add food essence 1g, add purified water to a preparation total of 1000ml, and fill to prepare a 10ml, 0.8g pidotimod oral liquid preparation.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides high concentration pidotimod oral liquid, which can promote human body immune response, effectively reduces times and degree of acute attack of infections caused by bacteria or virus, shortens disease course, can serve as auxiliary medicine antibiotic of acute infection and belongs to the field of medicines. The oral liquid contains constitutions of pidotimod, chemical stabilizer, a potential of hydrogen (pH) adjusting agent, a flavoring agent and the like. Tris-(hydroxymethyl)-aminomethane is used as the pH adjusting agent. The oral liquid is stable in quality and convenient to store for a long time. By means of quantitative proportioning and synergistic effect of all constitutions, when the concentration of the oral liquid is improved, simultaneously the stability and taste of the oral liquid are obviously improved. The oral liquid doesn't contain sugar capable of being absorbed and used by human bodies and is suitable for the old and children.

Description

technical field [0001] The invention relates to an oral liquid preparation containing high-concentration pidotimod, which belongs to the field of medicines. Background technique [0002] The immune response in the human body exists in the occurrence and development of many diseases, including specific immune response and non-specific immune response, which directly affects the health of the human body. Pidotimod is a safe and effective immune function enhancer, which can promote both specific immune response and non-specific immune response. Animal experiments and clinical experiments have shown that although pidotimod has no direct antibacterial and antiviral activity, it can significantly play a role in treating bacteria (pneumococcus, Escherichia coli, Pseudomonas aeruginosa, Proteus, etc.) ), fungus, virus (influenza virus, herpes simplex virus, myocarditis virus and Menge virus, etc.) It can effectively reduce the number and degree of acute attacks and shorten the cou...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K38/05A61K47/18A61K47/04A61P37/04
Inventor 米靖宇姚建林阎政赵唯一汪志超吴振邦王金陵冯志英臧建英
Owner SUZHOU SIXTH PHARMA PLANT OF JIANGSU WUZHONG PHARMA GROUP
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com