Hydrolysis outer circulation heat exchange process and device for friedel-crafts reaction liquid for synthesis of ibuprofen

Abstract

The invention relates to a hydrolysis outer circulation heat exchange process and a hydrolysis outer circulation heat exchange device for a friedel-crafts reaction liquid for synthesis of ibuprofen. In the process, the temperature in the hydrolysis process of the friedel-crafts reaction liquid is controlled by an outer circulation heat exchange process, so the friedel-crafts reaction liquid can be hydrolyzed smoothly, the reaction temperature in the hydrolysis process can be controlled stably, the heat transfer efficiency can be improved, maintenance cost of equipment is reduced, and the problem of unqualified product caused by corrosion and leakage can be avoided.

Description

technical field [0001] The invention belongs to the technical field of pharmacy, and in particular relates to a Friedel-Crafts reaction liquid hydrolysis external circulation heat exchange process and device for ibuprofen synthesis. Background technique [0002] Ibuprofen is one of the three pillar products of antipyretic and analgesic drugs. It was first synthesized by Nicholson in 1964. In the late 1980s, the appearance of carboxylation and 1,2-transposition technology made its production scale greatly improve. Since ibuprofen is a non-steroidal anti-inflammatory drug, which has strong anti-inflammatory, analgesic, antipyretic, anti-rheumatic effects, and low toxicity, it has been developed rapidly in recent years. Although various new ibuprofen production techniques have occurred, due to the limitations of conditions such as yield, equipment, three wastes, and safety, the current domestic industrial production of ibuprofen mainly adopts the glycidyl ester method, that is...

AI Technical Summary

Problems solved by technology

At present, the following problems exist in the hydrolysis of the Friedel-Crafts reaction solution in industry: Since the hydrolysis tank of the Friedel-Crafts reaction solution uses an inner coil heat exchanger for heat exchange, the Friedel-Crafts reaction solution has strong corrosion on the heat exchanger The internal titanium coil is often partially damaged due to corrosion, causing the Friedel-Crafts reaction solution to mix with low-temperature brine, thereby polluting the low-temperature brine of the entire factory, and the Friedel-Crafts reaction solution is also polluted, and the product quality is unqualified

On the other hand, the titanium tube used in the heat exchanger is expensive, and the maintenance cost is very high. Frequent replacement will cause a great economic burden on the workshop, which makes the production cost high and reduces the economic benefit.

From the perspective of heat transfer, the heat transfer efficiency of the heat transfer method with built-in titanium coil is low, which limits the improvement of the production capacity of the hydrolysis process

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