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Tasteless quick-releasing berberine hydrochloride pellet

A technology of berberine hydrochloride and pellets, which is applied in the direction of bulk delivery, medical preparations of non-active ingredients, cardiovascular system diseases, etc., can solve the problems of affecting bioavailability and poor absorption of berberine hydrochloride, and achieve delay release effect

Active Publication Date: 2013-10-23
杭州高成生物营养技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Berberine hydrochloride is poorly absorbed in the gut, affecting its bioavailability

Method used

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  • Tasteless quick-releasing berberine hydrochloride pellet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Step 1: Production of base pill core:

[0030] Percentage by weight: microcrystalline cellulose: 50%, starch: 30%, low-substituted-hydroxypropyl cellulose: 20%, and a diameter of 0.2-0.7mm to make nearly round particles with 8% polyvinylpyrrolidone aqueous solution. Fluidized bed drying and sieving to make the moisture content of the finished product ≤5%.

[0031] Step 2: Production of taste-masking coating powder:

[0032] Percentage by weight: after mixing fine powders of acrylic resin IV: 30%, magnesium stearate: 45%, and talcum powder: 25%, add ethanol to prepare a 5% solution.

[0033] Step 3: Production of tasteless immediate-release berberine hydrochloride pellets:

[0034] According to percentage by weight: berberine hydrochloride: 30%, adjuvant; 50% (making fast disintegrating type base pill core), masking taste coating material: 20% requirement, the base pellet core core that will make is placed in fluid flow In the fluidized bed, spray into the prepared be...

Embodiment 2

[0036] Step 1: Production of base pill core:

[0037] Percentage by weight: microcrystalline cellulose: 45%, starch: 38%, low-substituted-hydroxypropyl cellulose: 17%, with 8% polyvinylpyrrolidone aqueous solution to make a diameter of 0.2-0.7mm near round particles, through Fluidized bed drying and sieving to make the moisture content of the finished product ≤5%.

[0038] Step 2: Production of taste-masking coating powder:

[0039] Percentage by weight: prepare the acrylic resin IV solution: 40% acrylic resin IV, 35% magnesium stearate, 25% talcum powder: add ethanol to prepare an 8% solution.

[0040] Step 3: Production of tasteless immediate-release berberine hydrochloride pellets:

[0041] According to percentage by weight: berberine hydrochloride: 35%, adjuvant; 40% (make fast disintegrating type base pill core), cover taste coating material: 25% requirement, the base pill that will make is added in fluidized bed Inside, first spray into the prepared berberine hydrochl...

Embodiment 3

[0043] Step 1: Production of base pill core:

[0044] Percentage by weight: microcrystalline cellulose: 45%, starch: 40%, low-substituted hydroxypropyl cellulose: 15%, made with 8% polyvinylpyrrolidone aqueous solution with a diameter of 0.2-0.7mm yellow nearly round particles , dried in a fluidized bed and sieved to make the moisture content of the finished product ≤5%.

[0045] Step 2: Production of taste-masking coating powder:

[0046] Percentage by weight: acrylic resin IV: 35%, magnesium stearate: 30%, and talcum powder: 35%, and ethanol is added to prepare a 6% solution.

[0047] Step 3: Production of tasteless immediate-release berberine hydrochloride pellets:

[0048] Percentage by weight: berberine hydrochloride: 32%, adjuvant; 40% (made of fast-disintegrating base pellet core), taste-masking coating material: 28%, the prepared base pellet core is placed in a fluidized bed Inside, first spray the prepared mixed solution of berberine hydrochloride and polyvinylpyrr...

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Abstract

The invention discloses a tasteless quick-releasing berberine hydrochloride pellet, which is prepared by main-drug berberine hydrochloride, an auxiliary material, a taste-masking coating material and an adhesive. The auxiliary material is prepared into a base bill core of the pellet, and the outer surface of the base bill core coats a layer of main-drug berberine hydrochloride, and the outer surface of the main-drug berberine hydrochloride coats a layer of taste-masking coating material. The quick-releasing berberine hydrochloride pellet is prepared by adopting a reasonable formula, then the taste-masking coating material is used for masking bitter taste through a coating method, and the release of the pellet in the mouth is delayed, so that the pellet releasing speed in gastric juice is ensured. More than 80 percent of the pellet can be released within 10 minutes, so that the pellet is quickly released in the stomach. Thus, the pellet is particularly suitable for children for direct taking.

Description

technical field [0001] The invention relates to an odorless quick-release berberine hydrochloride pellet for treating gastrointestinal diseases of infants and belongs to the technical field of pharmaceutical production. Background technique [0002] Berberine hydrochloride is effective against intestinal infections (including bacillary dysentery), conjunctivitis, and suppurative otitis media caused by Shigella, Escherichia coli, and Staphylococcus aureus. It also has an effect on Helicobacter pylori, and can relieve gastritis, gastric and duodenal ulcers. Recently, it was also found that berberine hydrochloride has the effect of blocking α-receptor and antiarrhythmia. Berberine hydrochloride is mainly used to treat intestinal infections, but its taste is extremely bitter, especially not suitable for children to take directly. Berberine hydrochloride is poorly absorbed in the intestine, affecting its bioavailability. Therefore, there is an urgent need to develop a taste-ma...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K31/4375A61K47/48A61P9/06A61P31/04
Inventor 冯利萍
Owner 杭州高成生物营养技术有限公司
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