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Preparation method of laponite (LAP)-doped polylactic acid-glycolic acid (PLGA) nanofiber

A technology of glycolic acid and nanofibers, which is applied in the fields of fiber chemical characteristics, spinning solution preparation, and medical preparations of non-active ingredients, etc., to achieve the effects of simple operation, easy product availability, and low raw material cost

Inactive Publication Date: 2012-06-20
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] But so far, there is no literature report on the preparation of PLGA / LAP composite nanofibers by electrospinning, and further evaluation of the mechanical properties, biological activity and blood compatibility of the composite nanofibers.

Method used

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  • Preparation method of laponite (LAP)-doped polylactic acid-glycolic acid (PLGA) nanofiber
  • Preparation method of laponite (LAP)-doped polylactic acid-glycolic acid (PLGA) nanofiber
  • Preparation method of laponite (LAP)-doped polylactic acid-glycolic acid (PLGA) nanofiber

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Take 4 parts of 0.8g PLGA, mix them with 2.4mL THF and 0.8mL DMF respectively, and stir at room temperature for 8h until PLGA is completely dissolved. 8mg, 24mg and 40mg of LAP powder were added to the 2nd, 3rd and 4th PLGA solution respectively. Magnetic stirring was used for 20 min at a stirring rate of 200 r / min to obtain PLGA and PLGA / LAP spinning solutions. PLGA, PLGA / 1%LAP, PLGA / 3%LAP and PLGA / 5%LAP nanofiber mats were prepared by electrospinning. Among them, the receiving distance is 15cm, the voltage is 20kV, and the flow rate is 0.8mL / h. The prepared composite nanofiber mat is dried in a vacuum oven for 48h to remove residual moisture and solvent.

[0051] SEM observation results show that the obtained PLGA, PLGA / 1% LAP, PLGA / 3% LAP and PLGA / 5% LAP nanofibers have regular morphology and regular surface, and the fiber diameters are 929±274nm, 617±178nm, 584±5nm, respectively. 167nm and 550±183nm (see attached figure 1 ). Comparing the diameters of four diffe...

Embodiment 2

[0053] The PLGA, PLGA / 1%LAP, PLGA / 3%LAP and PLGA / 5%LAP nanofiber mats prepared in Example 1 of a certain mass (about 5mg) were weighed respectively for testing the thermodynamic properties of fiber materials (see attached figure 2 ). The thermodynamic performance test results show that when a certain amount of LAP nanoparticles is doped in the PLGA spinning solution, the melting point and glass transition temperature of the fiber mat decrease very little, indicating that LAP doped in the PLGA fiber will not be obvious Reduced thermal stability of PLGA nanofiber mats.

Embodiment 3

[0055] The PLGA, PLGA / 1% LAP, PLGA / 3% LAP and PLGA / 5% LAP nanofiber mats prepared in Example 1 were cut into strips of 1 cm×5 cm, and 3 parallel samples were taken for each sample. Measure the thickness of 3 different positions of each fiber mat with a micrometer, and calculate the average value as the thickness of each sample. Test the mechanical properties of the fiber mat with a universal material testing machine to obtain a stress-strain curve (see attached image 3 ). It can be seen from the stress-strain curve that the fracture strength of PLGA nanofibers can be significantly improved after a certain amount of LAP is doped in PLGA fibers.

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Abstract

The invention relates to a preparation method of laponite (LAP)-doped polylactic acid-glycolic acid (PLGA) nanofiber. The method comprises the following steps of: (1) dissolving PLGA into a THF (Tetrahydrofuran) / DMF (Dimethyl Formamide) mixed solvent, and stirring for fully dissolving the PLGA to obtain a PLGA electrostatic spinning solution; (2) uniformly dispersing the LAP into the PLGA electrostatic spinning solution while stirring to obtain a PLGA / LAP electrostatic spinning solution; and (3) performing electrostatic spinning by using the PLGA / LAP electrostatic spinning solution to obtain a PLGA / LAP composite nanofiber felt and drying. The process of the method is simple, a product is easy to prepare, and the PLGA and LAP used have low costs; and the prepared LAP-doped polylactic acid-glycolic acid nanofiber has high mechanical property, high thermal stability, high blood compatibility and high biocompatibility, and has a wide application prospect in the fields of medicament carriers, tissue engineering bracket materials and the like.

Description

technical field [0001] The invention belongs to the field of preparation of polylactic acid-glycolic acid nanofibers, in particular to a preparation method of hectorite-doped polylactic acid-glycolic acid nanofibers. Background technique [0002] Electrospinning refers to a new spinning method that uses electrostatic field force to make charged polymer solution or melt jet and draw in an electrostatic field to form micro-nano-sized fibers. Electrospinning technology is currently the only new spinning technology that can directly and continuously prepare polymer nanofibers. The fibers prepared by electrospinning technology have the characteristics of high porosity, large specific surface area, high fiber fineness and uniformity, and large aspect ratio. These excellent properties that cannot be obtained by traditional spinning methods endow electrospun fibers with a wide range of application prospects. In addition, electrospinning technology also has a series of advantages s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D01F6/92D01F1/10D04H1/728D01D1/02A61K47/34A61K47/02A61L27/44
Inventor 史向阳王世革郑付印
Owner DONGHUA UNIV
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