Ibuprofen diphenhydramine dispersing tablet and preparation method thereof

Abstract

The invention provides an ibuprofen diphenhydramine dispersing tablet, which consists of the following components in percentage by mass: 40 percent of ibuprofen, 5 percent of diphenhydramine hydrochloride or 7.6 percent of diphenhydramine citrate, 30-43 percent of a filler, 5-15 percent of a disintegrant, 2-8 percent of a bonding agent, 0.1-1 percent of a surfactant, 1.5-4 percent of a lubricating agent and 0.5-1.5 percent of a flavoring agent, wherein the filler is at least two of microcrystalline cellulose, pre-gelatinized starch, lactose and mannite; the disintegrant is cross-linked sodiumcarboxymethylcellulose and / or cross-linked polyvidone; the bonding agent is polyvidone K30; the surfactant is sodium dodecyl sulfate; the lubricating agent is magnesium stearate and superfine silica gel powder; and the flavoring agent is aspartame and steviosin. The invention further provides a preparation method of the dispersing tablet. The preparation method is easy and convenient to operate, has low cost, and is suitable for industrial production. An obtained product has stable and controllable quality, attractive appearance, good mouthfeel and proper hardness, is fully disintegrated in water at the temperature of 20+ / -1 DEG C within 3 minutes, and passes through a No.2 sieve; and the medicament dissolvability is over 85 percent 30 minutes later.

Description

technical field [0001] The invention belongs to the field of pharmacy, and relates to a pharmaceutical preparation and a preparation method of the preparation. Background technique [0002] Pain is a symptom associated with many diseases, and it is also a disease with multiple characteristics such as physiology, psychology and society. Pain can be caused by many reasons, and usually it is mainly caused by noxious stimuli that cause tissue damage, such as mechanical stimuli such as knife cutting and stick hitting, as well as noxious stimuli caused by electric current, strong acid, and strong alkali. Pain can be further divided into sharp pain and dull pain. Sharp pain has a stronger sense of pain and a shorter duration, such as tingling pain, cramping pain, burning pain and electric shock-like pain, etc. It is more common in trauma, surgery, inflammation, visceral injury and malignant tumors. Dull pain is milder and lasts longer, such as distending pain, dull pain, soreness ...

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