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Biodegradable strontium-doped calcium sulfate material having biological activity, and its preparation method and use

A bioactive and biodegradable technology, which is applied in the field of preparation and bioactive strontium-doped calcium sulfate materials, can solve the problems of component uniformity, particle size control, and difficulty in achieving satisfactory degradability of calcium sulfate, so as to improve biological effects and consumption The effect of low energy and simple preparation process

Active Publication Date: 2012-05-02
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this material improves the biological activity of calcium sulfate self-curing materials to a certain extent, it is difficult to achieve satisfactory results in the uniformity of components, particle size control and degradation of calcium sulfate in the composite formed by mechanical mixing.

Method used

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  • Biodegradable strontium-doped calcium sulfate material having biological activity, and its preparation method and use
  • Biodegradable strontium-doped calcium sulfate material having biological activity, and its preparation method and use
  • Biodegradable strontium-doped calcium sulfate material having biological activity, and its preparation method and use

Examples

Experimental program
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Effect test

Embodiment 1

[0030] 1) Will contain 0.2 mol / L CaCl 2 and 0.04 mol / L Sr(NO 3 ) 2 250 mL aqueous solution containing 0.04 mol / L sodium dodecylsulfonate was mixed, and then the mixed solution was added dropwise to the 0.12 mol / L (NH 4 ) 2 SO 4 In 500 mL of aqueous solution, a chemical precipitation reaction occurs, and particles are precipitated. After centrifugation, they are washed twice with deionized water and absolute ethanol, and then washed at 80 o C dried under vacuum to obtain strontium-doped calcium sulfate dihydrate.

[0031] 2) The strontium-doped calcium sulfate dihydrate particles prepared in the above step 1) were mixed at 155 o C oven was heat-treated for 1 hour, and then 10 g of microparticles after heat treatment were mixed with 6 g of normal saline to form a paste, which gradually solidified after 4 hours of hydration reaction and formed a porous solidified material. Tested by flame plasma emission spectrometry, the strontium content in the particles after heat treatm...

Embodiment 2

[0033] The preparation method is the same as in Example 1, except that step 1) will contain 0.4 mol / L CaCl 2 and 0.08 mol / L Sr(AC) 2 250 mL aqueous solution containing 0.08 mol / L sodium dodecylsulfonate was mixed, and then the mixed solution was added dropwise to the 0.24 mol / L (NH 4 ) 2 SO 4 In 500 mL aqueous solution, a chemical precipitation reaction occurs, and the dried particles are at 160 o Under C, process 2 hours, all the other processes are with embodiment 1. Tested by flame plasma emission spectrometry, the strontium content in the particles after heat treatment is 1.23%, with figure 1 (b) The particle X-ray diffraction pattern after heat treatment is mainly the diffraction peak of α-calcium sulfate hemihydrate, and contains a weak SrSO 4 diffraction peaks, indicating that the particles contain a small amount of SrSO 4 ; attached figure 2 The scanning electron micrograph of (b) shows that the particles after heat treatment are flake-like and rod-like mixed ...

Embodiment 3

[0035] The preparation method is the same as in Example 1, except that step 1) will contain 0.8 mol / L Ca(AC) 2 and 0.24 mol / L Sr(NO 3 ) 2 250 mL aqueous solution containing 0.2 mol / L sodium dodecylsulfonate was mixed, and then the mixed solution was added dropwise to the 0.52 mol / L K containing 0.52 mol / L K 2 SO 4 In the 500 mL aqueous solution, chemical precipitation reaction occurs, and all the other treatments are the same as in Example 1. Tested by flame plasma emission spectrometry, the strontium content in the particles after heat treatment is 3.68%, with figure 1 (c) The particle X-ray diffraction pattern after heat treatment is mainly the diffraction peak of α-calcium sulfate hemihydrate, and contains a small amount of SrSO 4 diffraction peaks, indicating that the particles contain a small amount of SrSO 4 ; attached figure 2 The scanning electron micrograph of (c) shows that the particles after heat treatment are rod-shaped particles; image 3 (c) The heat-tr...

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Abstract

The invention discloses a biodegradable strontium-doped calcium sulfate material having biological activity, and its preparation method and use. The preparation method comprises the following steps of mixing a solution containing Ca<2+> and Sr<2+> and a sodium dodecanesulphonate solution, dropwisely adding the mixed solution into an inorganic salt solution containing SO4<2-> continuously subjected to ultrasonic and stirring treatment so that strontium-doped calcium sulfate dehydrate particles are precipitated, carrying out filtration, washing and drying of the strontium-doped calcium sulfate dehydrate particles, heating at a temperature of 150 to 170 DEG C to obtain strontium-doped alpha-calcium sulfate hemihydrate particles, mixing the strontium-doped alpha-calcium sulfate hemihydrate particles and normal saline into paste according to a solid / liquid ratio of 0.5-2.0, and carrying out a hydration reaction and solidification formation process. The biodegradable strontium-doped calcium sulfate material having biological activity can be continuously degraded and release calcium, strontium and sulfate ions in a bone injury, and is suitable for drug slow release and healing of various human bone and tooth injuries. The preparation method has the characteristics of simple processes, and good controllability of particle morphology, particle sizes and a strontium doping ratio.

Description

technical field [0001] The invention relates to a biomedical material, in particular to a biodegradable bioactive strontium-doped calcium sulfate material, a preparation method and application. Background technique [0002] Bone defects caused by tumors, trauma, infection, deformity, etc. need to be filled and regenerated to restore their shape and function. Although autologous bone grafts can provide a scaffold for new bone growth and contain a large number of active osteoblasts, thereby promoting osteogenesis (Cypher TJ, Grossman JP, J Fooot Ankle Surg . 1996; 35: 413-417). However, in the process of autologous bone grafting, the osteoblasts in the bone block may not survive, so the clinical effect cannot be fully effective (Sandhu HS, Grewal HS, Orthop Clin North Am . 1999; 30:685-698). At the same time, autologous bone transplantation has disadvantages such as less bone mass and secondary trauma, which greatly limits its clinical application. Some scholars have repo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/02A61K47/04A61K6/027
Inventor 苟中入张峰汪麟杨贤燕陈晓怡
Owner ZHEJIANG UNIV
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