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Anti-radiation Chinese medicine preparation and preparation method thereof

A traditional Chinese medicine preparation and anti-radiation technology, applied in the field of medicine, can solve the problems of high cost, high toxicity and side effects, unfavorable preventive medication, etc., achieve low cost, low toxicity and side effects, and reduce the micronucleus rate of bone marrow cells

Inactive Publication Date: 2012-03-28
THE SECOND AFFILIATED HOSPITAL ARMY MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, cytokine therapy has a good prospect but is expensive; sulfur-containing compounds and hormones have relatively large toxic and side effects, which is not conducive to preventive medication

Method used

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  • Anti-radiation Chinese medicine preparation and preparation method thereof
  • Anti-radiation Chinese medicine preparation and preparation method thereof
  • Anti-radiation Chinese medicine preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment 1, the preparation of anti-radiation Chinese medicine preparation

[0017]

[0018] Preparation method: Take 11 medicinal materials such as Astragalus membranaceus according to the prescription, grind them into fine powder, add 8 times the amount of ethanol solution with a volume fraction of 70%, reflux extraction for 2 hours, extract twice in total, combine the extracts, filter, and recover the filtrate solvent to a thick paste, and then dried under reduced pressure into powder to obtain the extract powder of the Chinese medicine composition; the extract powder of the obtained Chinese medicine composition and microcrystalline cellulose are mixed in a weight ratio of 2:1, and the volume fraction Make soft materials from 95% ethanol solution, granulate with No. 2 sieve, dry at 60°C, granulate with No. 2 sieve, put into empty capsules, and make 1500 capsules.

[0019] During the experiment, it was found that the extract powder of the obtained traditional Ch...

Embodiment 2

[0020] Embodiment 2, pharmacodynamic research of anti-radiation Chinese medicine preparation

[0021] Kunming mice aged 8-10 weeks and weighing 18-20g were randomly divided into normal control group, radiation model group, high-, medium-, and low-dose groups of anti-radiation Chinese medicine preparations and positive drug groups (Diyu Shengbai Tablet group) or Yixuesheng capsule group), 10 per group. The normal control group and the radiation model group were intragastrically administered normal saline, the anti-radiation Chinese medicine preparation high, medium and low dose groups were intragastrically administered the capsule content solution prepared according to prescription 3 in Example 1, and the positive drug group were intragastrically administered the corresponding drug solution. After 7 days, except for the mice in the normal control group, the mice in the other groups were 60 Coγ irradiation, the dose is 5Gy. After irradiation, each group continued to gavage t...

Embodiment 3

[0061] Embodiment 3, toxicological research of anti-radiation Chinese medicine preparation

[0062] According to the "Technical Guidelines for Acute Toxicity Research of Traditional Chinese Medicines and Natural Medicines", the acute toxicity study of anti-radiation traditional Chinese medicine preparations was carried out. Kunming mice were used, half male and half male. Before the experiment, they were fasted for 12 hours, and the mice in the test group were given the capsule content solution prepared according to the prescription 3 of Example 1 at the maximum dosage, once in the morning and evening; the mice in the control group were given the same amount of normal saline. The body weight, diet, appearance, behavior, secretion, excretion, poisoning and death of mice in each group were observed for 14 consecutive days. The results showed that the maximum dose of anti-radiation traditional Chinese medicine preparations administered to mice twice a day was 293.6g / Kg, equiva...

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Abstract

The invention discloses an anti-radiation Chinese medicine preparation and a preparation method thereof. The preparation is a capsule which is prepared by mixing extract powder of a Chinese medicine composition and microcrystalline cellulose with the weight ratio of 2:1, wherein the Chinese medicine composition consists of ingredients according to parts by weight: 160-200 parts of astragalus mongholicus, 110-130 parts of fructus psoraleae, 80-100 parts of angelica sinensis, 160-200 parts of herba epimedii, 135-165 parts of madder root, 110-130 parts of fructus ligustri lucidi, 110-130 parts of radix paeoniae alba, 110-130 parts of radix rehmanniae preparata, 80-100 parts of ligusticum wallichii, 215-265 parts of rhizoma dioscoreae and 35-45 parts of radix glycyrrhizae preparata, and the extract powder is dry powder of ethanol solution extract of the Chinese medicine composition. The anti-radiation Chinese medicine preparation is precise in anti-radiation treatment effect, low in toxicside effects, simple in preparation method, low in cost, convenient to carry, easy to store, convenient to take and accurate in dosage, thus having good development and application prospect in the prevention and treatment of radiation injury.

Description

technical field [0001] The invention belongs to the field of medicine, relates to a traditional Chinese medicine preparation, and also relates to a preparation method of the preparation. Background technique [0002] With the development of modern nuclear military technology, soldiers are increasingly threatened by nuclear radiation, and the possibility that terrorists use nuclear loads, nuclear materials or radioactive substances to carry out terrorist sabotage activities is also increasing. In the face of the increasing energy crisis and the greenhouse effect and environmental pollution caused by the use of fossil energy, nuclear energy is a clean and efficient energy source, and the peaceful development and use of nuclear energy is also the development direction of the energy industry for a long period of time in the future. In addition, the use of medical equipment such as nuclear magnetic resonance, isotopes, and medical X-rays has also increased the possibility of medi...

Claims

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Application Information

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IPC IPC(8): A61K36/8945A61K47/38A61K9/48A61P17/16A61P39/06A61P7/00
Inventor 张恩娟邢茂枉前樊丽胡雪莲雷健
Owner THE SECOND AFFILIATED HOSPITAL ARMY MEDICAL UNIV
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