Saussurea involucrate extractive microemulsion compound

Abstract

The invention discloses a saussurea involucrate extractive microemulsion compound which comprises saussurea involucrate extractive and auxiliary materials; wherein the saussurea involucrate extractive is a substance containing rutin and chlorogenic acid, and the auxiliary materials consist of emulsifier, auxiliary emulsifier, an oil phase and a water phase; the emulsifier contains at least one of cremophor EL, polyoxyethylene hydrogenated castor oil, lecithin and tween-80; the auxiliary emulsifier contains at least one of isopropyl alcohol, propylene glycol, ethanol and glycerol; the oil phase contains at least one of ethyl oleate, oleic acid, caprylic triglyceride, isopropyl myristate and isopropyl palmitate; the water phase contains at least one of distilled water, purified water and injection water; and the saussurea involucrate extractive microemulsion compound contains 0.1-5 parts of saussurea involucrate extractive, 5-14 parts of emulsifier, 14-28 parts of auxiliary emulsifier, 4-18 parts of oil phase and 40-70 parts of water phase. The saussurea involucrate extractive microemulsion compound is prepared through pharmaceutical means by taking the microemulsion as a carrier, which remarkably increases the solubility of the saussurea involucrate extractive.

Description

technical field [0001] The invention relates to a microemulsion composition of snow lotus extract which can significantly increase the solubility of snow lotus extract. Background technique [0002] Snow lotus is an important medicinal plant in the high mountain area of ​​western my country. It is a kind of ethnic medicine commonly used in Tibetan medicine, Mongolian medicine and Uighur medicine. It is also recorded in "Compendium of Materia Medica Supplements" and "Xinjiang Chinese Herbal Medicine" in the Qing Dynasty. It is mainly distributed in Tianshan and Kunlun Mountains in Xinjiang, my country, and grows above the snow line. Folks use the whole herb as medicine. It is warm in nature and slightly bitter in taste. It enters the three meridians of liver, spleen and kidney. Arthritis, cold pain in the lower abdomen, irregular menstruation, etc. Because of its important medicinal value, it has been the object of people's attention and research for many years. [0003] I...

AI Technical Summary

Problems solved by technology

[0007] Chinese patent authorization announcement number is CN101209274B discloses a kind of snow lotus extract and its production method, but this patent does not aim at the dissolving property of the active ingredient in the snow lotus extract, provides a kind of pharmaceutical method that increases the solubility of the active ingredient in the snow lotus extract, At the same time, it does not provide a dosage form that satisfies the transdermal administration of Saussurea officinalis extract against the medicinal effects of the active ingredients in Saussurea officinalis extract