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Isoliquiritigenin micro-emulsion composition

A technology of isoliquiritigenin and microemulsion, which is applied in the direction of drug combination, antiviral agent, antiviral agent, etc., can solve the problems of restricting the effective development and utilization of preparations, and achieve the effect of simple preparation method

Inactive Publication Date: 2011-06-29
石河子大学医学院第一附属医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The poor water solubility of isoliquiritigenin limits the effective development and utilization of its preparations

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Isoliquiritigenin: 0.1 parts, polyoxyethylene castor oil: 5 parts, ethanol: 10 parts, isopropyl myristate: 10 parts, water: 30 parts

Embodiment 2

[0013] Isoliquiritigenin: 0.3 parts, lecithin: 9 parts, ethanol: 9 parts, isopropyl palmitate: 10 parts, water: 20 parts

Embodiment 3

[0015] Isoliquiritigenin: 0.4 parts, Tween-80: 10 parts, Propylene Glycol: 5 parts, Ethyl Oleate: 10 parts, Water: 35 parts

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PUM

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Abstract

The invention discloses micro-emulsion composition containing isoliquiritigenin which comprises isoliquiritigenin, emulsifying agent, assistant for emulsifying agent, oil and water. By using the composition, the solubility of the isoliquiritigenin can be greatly improved.

Description

technical field [0001] The invention relates to an isoliquiritigenin microemulsion composition capable of significantly increasing the solubility of isoliquiritigenin. Background technique [0002] Isoliquiritigenin is an important chalcone compound extracted from the roots and rhizomes of Glycyrrhiza plants of the leguminous family. It has anti-tumor, anti-virus, anti-free radical, inhibits lipid peroxidation, and inhibits immunodeficiency virus HIV and other biological activities, in addition, it can also treat intestinal spasms, diabetes, depressive psychosis, etc. Among them, the antitumor effect is a research hotspot at home and abroad in recent years. Isoliquiritigenin is a weak acid drug, insoluble in water, easily soluble in methanol, ethanol, ethyl acetate, insoluble in petroleum ether. The poor water solubility of isoliquiritigenin limits the effective development and utilization of its formulations. [0003] Chinese patent announcement number CN 101648883A disc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K31/12A61P1/06A61P3/10A61P25/24A61P31/12A61P31/18A61P35/00A61P39/06
Inventor 王新春邢建国陈文袁勇王鲁妹陈卫军韩博连文元谢敏苏红樊新梅
Owner 石河子大学医学院第一附属医院
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