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Chinese medicinal composition for preventing and treating inflammation-related diseases

A composition and correlation technology, which is applied in the field of pharmaceutical composition composed of extracts and traditional Chinese medicine composition for preventing and treating inflammation-related diseases, and can solve problems such as decreased hormone sensitivity and increased toxic and side effects

Active Publication Date: 2012-02-01
AFFILIATED HUSN HOSPITAL OF FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Clinical practice shows that glucocorticoids are an important means of treatment. However, long-term use of glucocorticoids has problems such as inhibition of the hypothalamus-pituitary-adrenal cortex axis, decreased sensitivity to hormones, and increased toxic side effects.

Method used

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  • Chinese medicinal composition for preventing and treating inflammation-related diseases
  • Chinese medicinal composition for preventing and treating inflammation-related diseases
  • Chinese medicinal composition for preventing and treating inflammation-related diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Taking Chinese medicinal materials Epimedium, Radix Astragali and Rehmannia glutinosa in parts by weight, decocting in 10 times the amount of water for 1 hour each time, twice in total, removing the dregs, concentrating the filtrate, drying into powder, and making a pharmaceutical composition.

[0016] In the present invention, pharmaceutically acceptable adjuvants or carriers can be added to prepare the desired pharmaceutical preparation, and the preparation is any pharmaceutically acceptable dosage form.

Embodiment 2

[0017] Embodiment 2: The influence experiment of this pharmaceutical composition on bronchial asthma

[0018] (1) Experimental animals: healthy and clean male guinea pigs were used, and they were raised in the Experimental Animal Center of Fudan University. The feeding conditions were clean, with fixed light time and free intake of water and food.

[0019] (2) Main reagents and instruments: ovalbumin (Shanghai Livzon Dongfeng Biotechnology Co., Ltd.); aluminum hydroxide gel (Sigma.Co.); sodium pentobarbital (Shanghai Chemical Reagent Company, imported repackaging); IL -4. IFN-γ kit (Biosource imported packaging); DL-8R refrigerated centrifuge (Shanghai Centrifugal Machinery Research Institute); YS9801 medical ultrasonic nebulizer (Shanghai Yisheng Technology Co., Ltd.); animal asthma induction device: Incompletely closed plexiglass box, 28×15×13cm 3 , one end of the box is a vent hole, and the other end is connected to an ultrasonic nebulizer.

[0020] (3) Preparation of ast...

Embodiment 3

[0035] Embodiment 3: The impact experiment of pharmaceutical composition of the present invention on chronic obstructive pulmonary disease

[0036] (1) Experimental animals: healthy and clean male SD rats were used, and they were raised in the Experimental Animal Center of Fudan University. The feeding conditions were clean, with fixed light time and free intake of water and food.

[0037] (2) Main reagents and instruments: Cigarettes (Shanghai Tobacco Group); LPS (Sigma.Co.); Pentobarbital Sodium (Shanghai Chemical Reagent Company, imported packaging); TNF-a, IL-8 kits (Biosource Imported packaging); DL-8R refrigerated centrifuge (Shanghai Institute of Centrifugal Machinery).

[0038] (3) Preparation of chronic obstructive pulmonary disease model

[0039] SD rats were anesthetized with ether inhalation on day 1 and day 15, and a midline neck incision was performed under aseptic operation to expose the trachea, and 200 μg (200 μL) of lipopolysaccharide (LPS) was slowly inject...

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Abstract

The invention belongs to the field of Chinese medicines, and particularly relates to a medicinal composition which consists of epimedium herb, astragalus and rehmannia root or extracts of the medicaments. Results of animal experiments indicate that the medicinal composition has a better curative effect on the prevention and treatment of inflammation-related diseases such as bronchial asthma, chronic obstructive pulmonary diseases or atopic dermatitis. A curative effect mechanism of the composition is related to the improvement on hypothalamus-hypophysis-adrenal cortex, the regulation of immunity and the inflammation of antagonism. In the medicinal composition, pharmaceutically-acceptable auxiliary materials or carriers are added to prepare a medicinal preparation, and the preparation is any one formulation which is pharmacologically accepted.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and relates to a traditional Chinese medicinal composition for preventing and treating inflammation-related diseases, in particular to a medicinal composition composed of Chinese medicinal materials epimedium, astragalus and rehmannia glutinosa or their extracts. The traditional Chinese medicine composition is used for preventing and treating inflammation-related diseases, such as bronchial asthma, chronic obstructive pulmonary disease or atopic dermatitis. Background technique [0002] According to clinical research reports, bronchial asthma, chronic obstructive pulmonary disease and atopic dermatitis are all inflammation-related diseases, which seriously threaten people's physical and mental health. The common pathophysiological basis of the above-mentioned inflammatory diseases is excessive local inflammation, immune disorder, and insufficient overall anti-inflammatory ability of th...

Claims

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Application Information

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IPC IPC(8): A61K36/804A61P29/00A61P11/06A61P11/00A61P17/00A61P37/02
Inventor 董竞成
Owner AFFILIATED HUSN HOSPITAL OF FUDAN UNIV
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