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Preparation method of uncaria total alkaloids

A technology of total alkaloids and Uncaria, which is applied in the field of preparing total alkaloids of Uncaria by membrane separation technology, which can solve the problems of operator hazards, excessive waste water, and easy volatility, and achieve the reduction of waste liquid generation, simple process operation, and The effect of low energy consumption

Inactive Publication Date: 2012-01-11
NANJING ZELANG AGRI DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] 1. Resin column separation produces more wastewater, especially ion exchange resin separation, which is not conducive to environmental protection and does not meet the current economic development requirements
[0006] 2. The extraction method uses a large amount of toxic and volatile reagents such as chloroform, which is volatile, seriously harmful to operators, and also has potential safety hazards

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] The medicinal material of Uncaria uncariae is crushed into granules, soaked in 10 kg of hydrochloric acid water with 6 times the amount of pH 1 for 6 hours, extracted 3 times, filtered the extract, and added a hollow polyamide cellulose ultrafiltration membrane system with a molecular weight cut-off of 3000 for ultrafiltration, and the permeate Add D101 non-polar macroporous resin column, collect the lower column liquid, elute the resin column with an appropriate amount of aqueous solution, add the combined liquid to a hollow polyamide fiber nanofiltration membrane system with a molecular weight cut off of 200 to concentrate, adjust the pH of the concentrated solution to 10 with ammonia water, and extract 3 times with chloroform, The reagent was recovered from the extract and dried to obtain 105 g of total alkaloids with a content of 84.6%.

Embodiment 2

[0021] Grind the medicinal material of Uncaria vine into granules, take 10kg and add 10 times the amount of sulfuric acid water with pH2, soak for 8 hours, extract twice, after filtering the extract, add a hollow polyethersulfone ultrafiltration membrane system with a molecular weight cut-off of 10000 for ultrafiltration, and add the permeate NKA-9 polar macroporous resin column, collect the lower column liquid, elute the resin column with an appropriate amount of aqueous solution, add the combined liquid to a hollow polyethersulfone nanofiltration membrane system with a molecular weight cut-off of 100 to concentrate, adjust the pH of the concentrated solution to 9 with ammonia water, and extract 4 times with chloroform, The reagent was recovered from the extract and dried to obtain 112 g of total alkaloids with a content of 81.3%.

Embodiment 3

[0023] The medicinal material of Uncaria uncariae is crushed into granules, soaked in 10kg of sulfuric acid water with 10 times the amount of pH2 for 8 hours, extracted twice, filtered the extract, and ultrafiltered with a hollow polytetrafluoroethylene ultrafiltration membrane system with a molecular weight cut-off of 3000, and the permeate Add AB-8 weakly polar macroporous resin column, collect the lower column liquid, elute the resin column with an appropriate amount of aqueous solution, add the combined liquid to a hollow polytetrafluoroethylene nanofiltration membrane system with a molecular weight cut-off of 200 to concentrate, adjust the pH of the concentrated liquid to 10 with ammonia water, and extract with chloroform 3 times, the reagent was recovered from the extract, and dried to obtain 131 g of total alkaloids with a content of 84.3%.

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PUM

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Abstract

The invention relates to a preparation method of an uncaria total alkaloids. The method comprises the following steps: crushing a medicinal material of uncaria; dipping with acid dip; extracting; filtering an extract; and adding into an ultrafiltration membrane system for ultrafiltration; adding a permeate into a macroporous resin column; collecting a lower column liquid and concentrating by a nanofiltration membrane system; adjusting a pH of a concentrated solution to 9-10 with ammonia; extracting by chloroform; recovering a reagent from the extract; and drying. The method employs a membrane filtration technology to reduce pollution and realize cyclic utilization of acid water in a production process, has a low energy consumption and is suitable for industrialized production.

Description

technical field [0001] The invention relates to a method for preparing total alkaloids of Uncaria, in particular to a method for preparing total alkaloids of Uncaria by membrane separation technology. Background technique [0002] Uncaria uncaria Uncaria rhynchophylla (Miq.) Jacks. , Uncaria Uncaria macrophylla Wall., Uncaria Uncaria hirsuta Havil. , Uncaria chinensis Uncaria sinensis (Oliv.) Havil. or Uncaria uncaria Uncaria sessilifructus Rox b. of dry hooked stems. Traditional medicine believes that Uncaria is sweet and cool in nature. Return liver, pericardium meridian, have the effect of clearing away heat and suppressing liver, subduing wind and relieving convulsion. It is often used to treat headache, dizziness, cold and convulsions, convulsions, pregnancy eclampsia, high blood pressure, etc. Modern research shows that Uncaria contains a large amount of alkaloids such as isorhynchophylline and rhynchophylline, which have antispasmodic, antihypertensiv...

Claims

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Application Information

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IPC IPC(8): A61K36/74A61P9/12A61P29/00A61P25/00A61P21/02A61K135/00
Inventor 苏刘花
Owner NANJING ZELANG AGRI DEV
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