Deproteinised porcine blood extract oral paste and preparation technology thereof

Abstract

The invention relates to a deproteinised porcine blood extract, especially to a deproteinised porcine blood extract oral paste and its preparation technology, is a medicine for treating oral mucosa, gum and lip injury, inflammation or ulcer, artificial denture pressure sore and the like, and belongs to the technical field of biological pharmacy. The deproteinised porcine blood extract oral paste is made from the following raw materials of: by weight, 0.1-0.3 part of a deproteinised porcine blood extract powder, 15-20 parts of pectin, 5.5-10.5 parts of glycerin, 9.1-19.3 parts of dimethicone, 30-40 parts of white vaseline, 20-30 parts of liquid paraffin and 0.05-0.1 part of methyl nipagin ester. The medicine provided by the invention is used to treat oral mucosa, gum and lip injury, inflammation or ulcer, artificial denture pressure sore and the like, can replace a similar biological product with bovine blood as a source, has high drug safety, and has a more obvious curative effect than a deproteinized calf blood oral paste.

Description

technical field [0001] The invention relates to a pig blood protein-free extract, in particular to a porcine blood protein-free extract oral ointment and a preparation process of the pig blood protein-free extract oral ointment. It is a new dosage form of pig blood protein-free extract. The pig blood protein-free extract oral ointment of the present invention is a medicine for treating oral mucosa, gum and lip damage, inflammation or ulcers, denture tray pressure sores, etc., and belongs to biological field of pharmaceutical technology. Background technique [0002] Oral ulcers are mostly seen in the mucous membranes of the lips, cheeks, soft palate, or gums of the oral cavity. Single or multiple round or oval ulcers of various sizes occur, the surface is covered with gray or yellow pseudomembrane, the center is depressed, and the border is clear. The mucous membrane is red and slightly swollen, and local burning pain of the ulcer is obvious, which has the characteristics o...

AI Technical Summary

Problems solved by technology

[0003] Chinese patent, the patent number is ZL200510132478.0, and the patent name "calf serum deproteinized oral ointment and its preparation method" discloses calf serum deproteinized oral ointment, which provides a kind of medicine for treating the above diseases, but this technology The protein-free extract pharmaceutical preparation is made of calf blood. Due to the limitations of the mad cow disease detection method and the limitation of mad cow disease virus inactivation, the drug effect is not ideal. Due to the selection of excipients, the drug has a slow onset of action , long course of treatment, widely restricted in clinical application

[0004] Although the deproteinized pig blood extract has the effect of promoting the uptake of oxygen and glucose by cells, it cannot be directly used in clinical applications of patients, and the extract is an aqueous solution with difficult storage conditions. Once the power failure will directly affect its quality

And the existing porcine blood deproteinized extract is an injection preparation, and its injection is mainly for the treatment of cerebrovascular diseases, and there is no report on oral injury and ulcer treatment research