Deproteinised porcine blood extract oral paste and preparation technology thereof

A deproteinization and extract technology, which is applied in the field of pig blood deproteinized extract and oral ointment of pig blood deproteinized extract, can solve the problems of clinical application of patients that cannot be directly used, unsatisfactory drug effect, difficult storage conditions, etc. Improves immunity, relieves ulcer congestion, and controls ulcer area

Active Publication Date: 2013-02-13
沈阳衡天然生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Chinese patent, the patent number is ZL200510132478.0, and the patent name "calf serum deproteinized oral ointment and its preparation method" discloses calf serum deproteinized oral ointment, which provides a kind of medicine for treating the above diseases, but this technology The protein-free extract pharmaceutical preparation is made of calf blood. Due to the limitations of the mad cow disease detection method and the limitation of mad cow disease virus inactivation, the drug effect is not ideal. Due to the selection of excipients, the drug has a slow onset of action , long course of treatment, widely restricted in clinical application
[0004] Although the deproteinized pig blood extract has the effect of promoting the uptake of oxygen and glucose by cells, it cannot be directly used in clinical applications of patients, and the extract is an aqueous solution with difficult storage conditions. Once the power failure will directly affect its quality
And the existing porcine blood deproteinized extract is an injection preparation, and its injection is mainly for the treatment of cerebrovascular diseases, and there is no report on oral injury and ulcer treatment research

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Preparation of pig blood deproteinized extract powder:

[0023] According to the preparation method described in the patent number ZL200510046289.1 and the invention titled "Method for Extracting Cellular Respiratory Activity from Pig Blood": Take healthy pigs that have passed inspection in non-infectious areas and use sterile blood to remove Fibrin, get 10L of defibrinated blood, freeze-thaw repeatedly (-20℃~40℃) 2-4 times; homogenize in a colloid mill at 2-8℃ for 2 minutes, repeat 3 times; take the homogenate in After centrifugation at 4000 rpm for 20 minutes, discard the precipitate; take the supernatant and use 100000D, 30000D, 10000, 6000D hollow fiber ultrafiltration columns to perform four-stage ultrafiltration in sequence to obtain 7.2L of filtrate; the final ultrafiltrate Put it into a reduced-pressure concentration tank, vacuum and concentrate with a jet vacuum pump at 55°C to a total solid content of more than 40mg / ml, to obtain 1.2L of pig blood deproteinized ...

Embodiment 2

[0025] Preparation of oral ointment with deproteinized extract of pig blood (Containing 0.1% of pig blood deproteinized extract powder, equivalent to 2.5% of pig blood deproteinized extract solution)

[0026] 1. Preparation of substrate

[0027] Take 750g of pectin, 275g of glycerin, 967.5g of dimethicone, 2000g of white petrolatum, 1000g of liquid paraffin, 2.5g of ethyl paraben, stir and mix well, and autoclave at 115°C (67kPa) for 30 minutes.

[0028] 2. Porcine blood deproteinized extract oral paste sub-packing

[0029] Take 5g of the deproteinized porcine blood extract powder prepared by the method in Example 1 and mix it evenly with the above-mentioned sterilized matrix, and then make 5000g oral paste, divide it with a filler, and pack it to the middle, each 5g, that is, 1000 pigs Blood deproteinized extract oral cream.

Embodiment 3

[0031] Preparation of oral ointment with deproteinized extract of pig blood (It contains 0.15% of pig blood deproteinized extract powder, which is equivalent to 3.75% of pig blood deproteinized extract solution)

[0032] 1. Preparation of substrate

[0033] Take 800 g of pectin, 325 g of glycerin, 864.5 g of dimethyl silicone oil, 1875 g of white petrolatum, 1125 g of liquid paraffin, and 3.25 g of ethyl paraben, stir and mix well, and autoclave at 120°C (75kPa) for 25 minutes.

[0034] 2. Porcine blood deproteinized extract oral paste sub-packing

[0035] Take 7.5g of the deproteinized porcine blood extract powder prepared by the method in Example 1 and mix it evenly with the above-mentioned sterilized matrix to make 5000g oral paste, divide it with a filler, and divide it into a medical polyethylene composite tube. 5g, 1000 sticks of porcine blood deproteinized extract oral paste.

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PUM

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Abstract

The invention relates to a deproteinised porcine blood extract, especially to a deproteinised porcine blood extract oral paste and its preparation technology, is a medicine for treating oral mucosa, gum and lip injury, inflammation or ulcer, artificial denture pressure sore and the like, and belongs to the technical field of biological pharmacy. The deproteinised porcine blood extract oral paste is made from the following raw materials of: by weight, 0.1-0.3 part of a deproteinised porcine blood extract powder, 15-20 parts of pectin, 5.5-10.5 parts of glycerin, 9.1-19.3 parts of dimethicone, 30-40 parts of white vaseline, 20-30 parts of liquid paraffin and 0.05-0.1 part of methyl nipagin ester. The medicine provided by the invention is used to treat oral mucosa, gum and lip injury, inflammation or ulcer, artificial denture pressure sore and the like, can replace a similar biological product with bovine blood as a source, has high drug safety, and has a more obvious curative effect than a deproteinized calf blood oral paste.

Description

technical field [0001] The invention relates to a pig blood protein-free extract, in particular to a porcine blood protein-free extract oral ointment and a preparation process of the pig blood protein-free extract oral ointment. It is a new dosage form of pig blood protein-free extract. The pig blood protein-free extract oral ointment of the present invention is a medicine for treating oral mucosa, gum and lip damage, inflammation or ulcers, denture tray pressure sores, etc., and belongs to biological field of pharmaceutical technology. Background technique [0002] Oral ulcers are mostly seen in the mucous membranes of the lips, cheeks, soft palate, or gums of the oral cavity. Single or multiple round or oval ulcers of various sizes occur, the surface is covered with gray or yellow pseudomembrane, the center is depressed, and the border is clear. The mucous membrane is red and slightly swollen, and local burning pain of the ulcer is obvious, which has the characteristics o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K35/14A61K47/44A61P1/02
Inventor 王光李莉万琳琳刘路徐丽颖
Owner 沈阳衡天然生物科技有限公司
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