Sertaconazole nitrate suppository for treating vaginitis and preparation method thereof

Abstract

The invention discloses a sertaconazole nitrate suppository for treating vaginitis and a preparation method thereof. According to the prescription, the suppository comprises sertaconazole nitrate, a framework material, a matrix, a stabilizing agent, a buffering agent and the like according to a certain proportion. The sertaconazole nitrate suppository has a reasonable formula, slowly releases in vaginas, is not required to be administrated frequently, and can eliminate fungal infection only by one dose of the suppository; and the sertaconazole nitrate suppository has the advantages of appropriate melting point, difficulty in rancidification, extremely good treatment effects on the vaginitis, high pharmacological activity, small toxic or side effects, high cure rate, capability of reducingrecurrence rate and the like, is easy to mold and is extremely suitable for clinical application.

Description

Technical field [0001] The invention relates to the field of pharmacy, more specifically to a sertaconazole nitrate suppository for treating vaginitis, and also to a preparation method of sertaconazole nitrate suppository. Background technique: [0002] Vaginitis is one of the most common inflammatory lesions in female reproductive organs. Pathogens are widespread and have a high incidence. If not treated in time, many complications can be induced. Because there are many pathogens that cause vaginitis, including fungi, viruses, trichomoniasis, chlamydia and mycoplasma, the treatment is complicated and the curative effect is limited. KR930010579B discloses a fenticonazole gel. Although the gel increases the skin permeability of fenticonazole, the dosage of the drug is difficult to control during use, and it is not convenient to use suppositories. [0003] Suppository bases are generally divided into fatty bases and water-soluble bases. It is generally believed that water-soluble...

AI Technical Summary

Problems solved by technology

Miconazole nitrate suppository is mainly used for local treatment of double infection caused by vulvovaginal candidiasis and Gram-positive bacteria, but the recurrence rate is high after cure, and the drug resistance is strong after long-term and large-scale use, and the curative effect is poor

Xiaomi suppository is mainly used for the treatment of cervical erosion, trichomonas vaginitis, fungal vaginitis and other diseases, the curative effect is slow, the recurrence rate is high, and it is not easy to be accepted by patients

Metronidazole suppositories are mainly used for the treatment of trichomoniasis vaginalis, long-term use is likely to produce relatively large adverse reactions, and the cure rate of single preparations is low

Fukangte Suppository is mainly used to treat fungal vaginitis, but it only has a good therapeutic effect on mild and moderate inflammation, and the therapeutic effect on severe inflammation is not ideal

The common suppository currently on the market will melt in about half an hour, easy to leak out, and the effective administration time is short

At the same time, large doses of administration will cause great irritation

In addition, the outflow of ordinary oil-soluble substrates is easy to contaminate clothes

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