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Chinese herbal extract for treating diabetic nephropathy and preparation method thereof

A technology of diabetic nephropathy and its extract, which is applied in the field of compound traditional Chinese medicine extract and its preparation for the treatment of diabetic nephropathy, can solve the problems that the pathogenesis has not been fully elucidated, and achieve the effects of protecting kidney function, preventing progress, and having no toxic and side effects

Active Publication Date: 2011-11-02
BEIJING HANDIAN PHARMA CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Diabetic nephropathy is the most important cause of end-stage renal disease (ESRF), and one of the main causes of death in diabetic patients. A lot of research has been done on this at home and abroad, but the pathogenesis has not been fully elucidated so far, and there is no effective drug prevent its occurrence and deterioration

Method used

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  • Chinese herbal extract for treating diabetic nephropathy and preparation method thereof
  • Chinese herbal extract for treating diabetic nephropathy and preparation method thereof
  • Chinese herbal extract for treating diabetic nephropathy and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Embodiment 1, preparation is used for the treatment of the traditional Chinese medicine compound granule of diabetic nephropathy

[0034] Composition of raw materials: 600g of astragalus, 400g of Gorgon fruit, 400g of golden cherry, 600g of invertebrate, 400g of Ligustrum lucidum, 400g of ghost arrow feather and 320g of rhubarb.

[0035] For the above seven traditional Chinese medicines, Radix Astragali is extracted twice with 60% ethanol aqueous solution under reflux, and the amount of alcohol added each time is 6 times the mass of Radix Astragali, extracted under reflux for 2 hours, and the extracts are combined and filtered. Mix Ligustrum lucidum and Gorgon fruit, add a mass concentration of 80% ethanol aqueous solution, heat and reflux for extraction 4 times, the amount of alcohol added each time is 5 times the mass of Ligustrum lucidum and Gorgon fruit, reflux extraction for 1 hour, combine the extracts, filter, Combine with the above filtrate, recover ethanol, con...

Embodiment 2

[0037] Embodiment 2, the clinical effect test of the traditional Chinese medicine compound granule for the treatment of diabetic nephropathy

[0038] 1. Research object

[0039] 1.1 Case selection

[0040] The cases in this study come from 150 outpatients and inpatients of Dongfang Hospital, Beijing University of Traditional Chinese Medicine. Among them, there were 74 males and 76 females.

[0041] 1.2 Western medicine diagnostic criteria

[0042] Type 2 diabetes diagnosed according to WHO diagnostic classification criteria (1999). Patients with early diabetic nephropathy. Diabetic nephropathy (DN) is diagnosed in accordance with the internationally recognized Mogensen diagnostic staging criteria (early DN is stage III of Mogensen staging). Diagnostic criteria for early DN: Urine examination within 3 months for two consecutive urine albumin excretion rate (UAE) 20-200μg / min (30-300mg / 24h), and exclude essential hypertension, heart failure, urinary tract infection, Ketoacid...

Embodiment 3

[0106] Embodiment 3, preparation is used for the treatment of the traditional Chinese medicine compound granule of diabetic nephropathy

[0107] Composition of raw materials: 1000g of astragalus, 480g of gorgon, 480g of golden cherry, 1000g of chamomile, 480g of privet fruit, 480g of ghost arrow feather and 400g of rhubarb.

[0108] For the above seven traditional Chinese medicines, Radix Astragali is extracted twice with 60% ethanol aqueous solution under reflux, and the amount of alcohol added each time is 6 times the mass of Radix Astragali, extracted under reflux for 2 hours, and the extracts are combined and filtered. Mix Ligustrum lucidum and Gorgon fruit, add a mass concentration of 80% ethanol aqueous solution, heat and reflux for extraction 4 times, the amount of alcohol added each time is 5 times the mass of Ligustrum lucidum and Gorgon fruit, reflux extraction for 1 hour, combine the extracts, filter, Combine with the above filtrate, recover ethanol, concentrate to ...

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Abstract

The invention discloses a Chinese herbal extract for treating diabetic nephropathy and a preparation method thereof. The Chinese herbal extract is prepared from 600 to 1000 parts by weight of Radix Astragali, 400 to 600 parts by weight of Gorgon fruit, 400 to 600 parts by weight of Cherokee rose-hip, 600 to 1000 parts by weight of Common achyranthes herb, 400 to 480 parts by weight of Ligustrum lucidum, 400 to 480 parts by weight of Ramulus Euonymi, and 320 to 480 parts by weight of Rheum officinale. Based on internationally unified clinical diagnostic criteria of diabetic nephropathy (DN), Compound particles of the Chinese herbal extract are carried out a comparison with Lotensin according to a randomized control principle through a contrast observation on 300 diabetic nephropathy patients taking respectively the compound particles and Lotensin, and a comparison result shows that 1) the compound particles can improve clinical symptoms of DN patients; and 2) the compound particles canreduce obviously urinary albumin in a DN early stage and urinary protein in a DN clinical stage, protect kidney functions and prevent effectively a development of early stage DN. Based on the prescribed curative effect evaluation criterion, a total effective rate of a Chinese herbal compound particle group is 86.7% and is obviously superior to that of a comparison group.

Description

technical field [0001] The invention relates to a compound traditional Chinese medicine extract for treating diabetic nephropathy and a preparation method thereof. Background technique [0002] Diabetic nephropathy (diabetic nephropathy, DN) is a common and frequently occurring clinical complication of diabetes, and it is also one of the most serious complications of diabetes. Diabetic nephropathy is the main microvascular complication of diabetes, mainly referring to diabetic glomerulosclerosis, a glomerular lesion mainly caused by vascular damage. It is mostly asymptomatic in the early stage, and the blood pressure can be normal or high, and its incidence increases with the prolongation of the course of diabetes. In the early stage of diabetes, the kidney volume increases, the glomerular filtration rate increases, and it is in a state of high filtration. Later, intermittent proteinuria or microalbuminuria gradually appears, and as the course of the disease prolongs, conti...

Claims

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Application Information

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IPC IPC(8): A61K36/736A61P3/10A61P13/12
Inventor 高彦彬
Owner BEIJING HANDIAN PHARMA CO LTD
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