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Pharmaceutical composition and purpose thereof

A composition and drug technology, applied in the field of biomedicine, can solve the problems of insignificant antihypertensive effect and large blood pressure fluctuation, and achieve the goal of protecting the structure and function of hypertensive target organs, improving the quality of life, and reducing drug side effects Effect

Active Publication Date: 2015-06-10
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0015] In order to solve the defects of the existing hypertension drugs with insignificant antihypertensive effect and large fluctuations in blood pressure during the antihypertensive process, the present invention provides a new pharmaceutical composition for treating hypertension and its complications. Tan and rosuvastatin are the active ingredients of the drug, which have comprehensive effects in the treatment of hypertension and its complications, can reduce cardiovascular and cerebrovascular risks, and have a significant and stable antihypertensive effect

Method used

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  • Pharmaceutical composition and purpose thereof
  • Pharmaceutical composition and purpose thereof
  • Pharmaceutical composition and purpose thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1 Preparation of Rosuvastatin and Fimasartan Compound Tablets

[0029] Rosuvastatin 8g

[0030] Fimasartan 2g

[0031] Compressible starch 120g

[0032] Cyclodextrin 10g

[0033] Sodium Carboxymethyl Starch 10g

[0034] Magnesium Stearate 0.6g

[0035] 5% PVP in absolute ethanol solution

[0036] Preparation process: first, put rosuvastatin and cyclodextrin in a mortar and mix them evenly, then add sodium carboxymethyl starch and compressible starch and mix them evenly, finally add Fimasartan and mix evenly, and use 5% PVP. The anhydrous ethanol solution was used as a binder for granulation, dried at 40°C, granulated, added with magnesium stearate, mixed evenly, and pressed into tablets.

Embodiment 2

[0037] Example 2 Preparation of Rosuvastatin and Fimasartan Compound Tablets

[0038] Rosuvastatin 8g

[0039] Fimasartan 80g

[0040] Compressible starch 130g

[0041] Cyclodextrin 10g

[0042] Sodium Carboxymethyl Starch 10g

[0043] Magnesium Stearate 0.6g

[0044] 5% PVP in absolute ethanol solution

[0045] Preparation process: first, put rosuvastatin and cyclodextrin in a mortar and mix them evenly, then add sodium carboxymethyl starch and compressible starch and mix them evenly, finally add Fimasartan and mix evenly, and use 5% PVP. The anhydrous ethanol solution was used as a binder for granulation, dried at 40°C, granulated, added with magnesium stearate, mixed evenly, and pressed into tablets.

Embodiment 3

[0046] Example 3 Preparation of Rosuvastatin and Fimasartan Compound Tablets

[0047] Rosuvastatin 0.1g

[0048] Fimasartan 25g

[0049] Microcrystalline Cellulose 150g

[0050] Beta-cyclodextrin 10g

[0051] Sodium Carboxymethyl Starch 15g

[0052] Micro Powder Silica 0.8g

[0053] Preparation process: first put rosuvastatin and β-cyclodextrin in a mortar to grind and mix evenly, then add sodium carboxymethyl starch, microcrystalline cellulose, micropowder silica gel and mix evenly, and finally add Fimasartan and mix evenly , the powder is directly compressed into tablets.

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Abstract

The invention belongs to the filed of medicine and discloses a pharmaceutical composition using fimasartan and rosuvastatin or medicinal salt thereof as active components, wherein a mass ratio of rosuvastatin or medicinal salt thereof to fimasartan is 1:0.25-250 and preferably 1:10-100. The pharmaceutical composition containing rosuvastatin medicinal salt thereof and fimasartan has obvious synergism on treating hypertension and complications thereof, low treatment cost, little side-effect and good clinic application prospect.

Description

technical field [0001] The invention belongs to the field of biomedicine, and relates to a pharmaceutical composition and use thereof, in particular to a pharmaceutical composition using Fimasartan and Rosuvastatin as active ingredients and a method for preparing the same for treating hypertension and its complications. Use in medicine. Background technique [0002] Hypertension is the most common cardiovascular disease and one of the largest epidemic diseases in the world. It often causes complications of the heart, brain, kidney and other organs, seriously endangering human health. Early prevention and timely treatment are of great significance, and the research and development of drugs for the treatment of cardiovascular diseases has become one of the hotspots in the field of medical research. [0003] Hypertension is a syndrome with complex etiology and pathogenesis. Once diagnosed, lifelong medication is required. At present, the medical community at home and abroad g...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/513A61K31/505A61K9/20A61K9/22A61K9/48A61K9/16A61P9/12
Inventor 赵志全王洪臣
Owner LUNAN PHARMA GROUP CORPORATION
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